Sentences with phrase «related genes implicated»
To test this hypothesis, an international team led by evolutionary biologist Philipp Khaitovich of the Shanghai Institutes for Biological Sciences in China and the Max Planck Institute for Evolutionary Anthropology in Leipzig, Germany, set out to see how many brain - related genes implicated in schizophrenia underwent positive natural selection since humans and chimpanzees diverged from a common ancestor between 5 million and 7 million years ago.
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Less clear is how this misfolding relates to the growing number of genes implicated in PD through analysis of human genetics.
They found that six of the categories included a high proportion of genes also implicated in schizophrenia; the genes in these six categories relate to energy metabolism.
In the new study, the researchers discovered that during the second trimester of human brain development, oRG cells express genes related to a fundamental signaling pathway called mTOR, defects in which have previously been implicated in autism and several other psychiatric disorders.
They hypothesized that the differences might be related to variations in two genes, called ASPM and microcephalin, which are thought to be implicated in brain development.
They note that this network is strongly related to genes previously implicated in studies of autism and intellectual disability.
Potential projects include identifying common pathways that modify retinal degenerative disease from a large collection of actively maintained mouse models; determining molecular networks implicated in pathological disruption of the retinal pigment epithelium; identifying molecular pathways that regulate postnatal ocular growth; and using mouse models to assess the pathogenic role of gene variants that increase the risk of age - related macular degeneration as identified by human genome - wide association studies.
The study implicates genes expressed in brain tissue, particularly those related to neuronal and synaptic function.
«The NFT is thought to be more closely related to memory decline than other forms of aging - related pathologies, but there are still very few genes that have been implicated in the accumulation of this key feature of Alzheimer's disease and other brain diseases.»
70/3: 15 Chromosome interaction analysis of risk loci in related autoimmune diseases reveals complex, long - range promoter interactions implicating novel candidate genes.