Sentences with phrase «related genes in humans»

In 1997 researchers in Ruvkun's laboratory at Harvard Medical School reported that the gene in question was the worm equivalent of a trio of insulin - related genes in humans.

Not exact matches

Katherine High, Spark's president and chief scientific officer, expressed her enthusiasm for the early clinical data related to SPK - 8011: «The encouraging start of our SPK - 8011 clinical trial reinforces the strength of our gene therapy platform, delivers human proof - of - concept in a second liver - mediated disease — a significant achievement in the gene therapy field — and positions us well to potentially transform the current treatment approach for this life - altering disease with a one - time intervention.»

In February, the United Kingdom approved using the method on human embryos at the Francis Crick Institute in London, but only within a narrow capacity: Researchers can edit genes in non-viable human embryos for a limited period and only to study developmental biology related to in vitro fertilizatioIn February, the United Kingdom approved using the method on human embryos at the Francis Crick Institute in London, but only within a narrow capacity: Researchers can edit genes in non-viable human embryos for a limited period and only to study developmental biology related to in vitro fertilizatioin London, but only within a narrow capacity: Researchers can edit genes in non-viable human embryos for a limited period and only to study developmental biology related to in vitro fertilizatioin non-viable human embryos for a limited period and only to study developmental biology related to in vitro fertilizatioin vitro fertilization.

Last week, Nicola Pirastu at the University of Trieste, Italy, and his colleagues told the European Society of Human Genetics meeting in Milan that diets tailored to genes that are related to metabolism can help people lose weight.

The total «knockout» of the gene makes the model more effective for studying SHANK3 - related autism and Phelan - McDermid syndrome in humans, many of whom are missing the gene completely, said senior author Yong - hui Jiang, M.D., Ph.D., an associate professor of pediatrics and neurobiology

No cases of severe pancreatitis and only one admission to the intensive care unit for an LPLD - related abdominal event were reported in the study published in Human Gene Therapy.

In the human body cells turn genes on and off by means of chemical modifications that change DNA and related proteins.

In the past decade, ethical questions in science have made headlines on issues such as the patenting of human genes, financial conflicts of interest in biomedical research and risk assessments related to environmental exposure to chemicalIn the past decade, ethical questions in science have made headlines on issues such as the patenting of human genes, financial conflicts of interest in biomedical research and risk assessments related to environmental exposure to chemicalin science have made headlines on issues such as the patenting of human genes, financial conflicts of interest in biomedical research and risk assessments related to environmental exposure to chemicalin biomedical research and risk assessments related to environmental exposure to chemicals.

Mice without the leptin gene, called ob / ob, overeat, weigh in at three to four times normal, and develop symptoms similar to the obesity - related diabetes seen in humans.

Less clear is how this misfolding relates to the growing number of genes implicated in PD through analysis of human genetics.

«Brain genes related to innovation revealed in birds: Glutamate brain receptors, linked with human intelligence, are also associated with problem - solving skills in wild birds.»

To test this hypothesis, an international team led by evolutionary biologist Philipp Khaitovich of the Shanghai Institutes for Biological Sciences in China and the Max Planck Institute for Evolutionary Anthropology in Leipzig, Germany, set out to see how many brain - related genes implicated in schizophrenia underwent positive natural selection since humans and chimpanzees diverged from a common ancestor between 5 million and 7 million years ago.

SIX3 and a related gene, SIX2, with a similar pattern of expression in human beta cells, encode proteins known as transcription factors that control the expression of many other genes in the cell.

And 40 genes involved in these nine schizophrenia - related pathways also differed much more between chimps and humans than genes associated with the other 12.

Spalax naturally have a variant in the p53 gene (a transcription factor and known tumor suppressor), which is identical to a cancer - related mutation in humans, Band said.

Of the 68 genes specific to females, many were related to immunity, and at least two are known to be overexpressed in human female B cells compared to male B cells.

In March 2002, Theodore Friedmann, who directs the program in human gene therapy at the University of California at San Diego and has advised the National Institutes of Health and congressional leaders on gene - related issues, organized a three - day workshop for the world agencIn March 2002, Theodore Friedmann, who directs the program in human gene therapy at the University of California at San Diego and has advised the National Institutes of Health and congressional leaders on gene - related issues, organized a three - day workshop for the world agencin human gene therapy at the University of California at San Diego and has advised the National Institutes of Health and congressional leaders on gene - related issues, organized a three - day workshop for the world agency.

By studying how these genes cause defects in fly and mouse models, we can improve our insights into the mechanisms related to human disease,» said corresponding author and Dr. Hugo J. Bellen, professor of neuroscience and molecular and human genetics at Baylor College of Medicine and an investigator at the Howard Hughes Medical Institute.

Unmanned autonomous vehicles designed to help combat the Zika virus, ethical and safety considerations related to new human gene - editing tools, advances in the fight against cancer and U.S. science policy following the presidential election will be a few of this year's headlines at the world's largest general scientific conference.

For Longo, it all added up: The same growth genes that regulate aging and protect against age - related diseases in yeast, mice, and roundworms might have an identical effect in humans.

By activating the Ret receptor, the scientists were able to prevent in flies and human cell cultures the degeneration of mitochondria, which is caused by a gene defect related to Parkinson's disease.

Insofar, the results are also relevant for humans: 85 % of the long - lived rodents» genes are identical to human DNA, but in contrast to humans that are rather prone to illness, long - lived rodents have a very low risk to come down with age - related diseases.

Consistent with that result, the researchers found that certain regions of the X chromosome in human female B cells, including regions that contain immunity - related genes, were expressed at higher levels than male cells.

The Oct. 11 - 13 conference, based in Hanover, Germany, assembled a global group of bioethics and government experts to address security questions on gene editing as they relate to human health, agriculture and the potential to genetically alter species.

Earlier versions of these «base editors,» which target typos related to the other half of disease - causing genetic spelling errors, have already been used to alter genes in plants, fish, mice and even human embryos.

In the new study, the researchers discovered that during the second trimester of human brain development, oRG cells express genes related to a fundamental signaling pathway called mTOR, defects in which have previously been implicated in autism and several other psychiatric disorderIn the new study, the researchers discovered that during the second trimester of human brain development, oRG cells express genes related to a fundamental signaling pathway called mTOR, defects in which have previously been implicated in autism and several other psychiatric disorderin which have previously been implicated in autism and several other psychiatric disorderin autism and several other psychiatric disorders.

As well as Zika virus, the team has also used SHERLOCK to detect antibiotic resistance genes in Klebsiella pneumoniae bacteria, and health - related gene variants in human saliva.

In humans, Galatzer - Levy found that different versions of the fkbp5 gene were able to predict specific differences in extinction learning related to PTSD symptoms such as reliving or re-experiencing the traumatic event; avoiding reminders of the event; and, in particular, hyperarousal, or the inability to sleep or concentratIn humans, Galatzer - Levy found that different versions of the fkbp5 gene were able to predict specific differences in extinction learning related to PTSD symptoms such as reliving or re-experiencing the traumatic event; avoiding reminders of the event; and, in particular, hyperarousal, or the inability to sleep or concentratin extinction learning related to PTSD symptoms such as reliving or re-experiencing the traumatic event; avoiding reminders of the event; and, in particular, hyperarousal, or the inability to sleep or concentratin particular, hyperarousal, or the inability to sleep or concentrate.

As well as Zika virus, the team has also used SHERLOCK to detect antibiotic resistance genes in Klebsiella pneumoniae bacteria, and health - related gene variants in human saliva (Science, DOI: 10.1126 / science.aam9321).

Working in the lab of Salk's Fred Gage, the Vi and John Adler Chair for Research on Age - Related Neurodegenerative Disease, Narvaiza, Marchetto and their colleagues identified genes that are differentially expressed between iPSCs from humans and both chimpanzees and bonobos.

Last year, University of Chicago geneticist Bruce Lahn reported that he had uncovered genes that are still evolving in humans, and he suggested that they confer a brain - related boost (see main text).

Still, Dudley feels that evolutionary genetic analysis can help identify the most relevant genes and pathological mechanisms at play in schizophrenia and possibly other mental illnesses that preferentially affect humans — that is, neurodevelopmental disorders related to higher cognition and GABA activity, including autism and attention - deficit / hyperactivity disorder.

For instance, the mouse sequence revealed that mice have two genes related to the gene involved in Lowe's syndrome, an inherited metabolic disorder in humans.

Alterations in replication timing of cancer - related genes in malignant human breast cancer cells.

In a 2016 National Institutes of Health summer internship at the National Human Genomic Research Institute, Sappington conducted a third research project in which she demonstrated a fast, alignment - free computational method for identifying orthologs — similar genes from species that are related by descent from a common ancestoIn a 2016 National Institutes of Health summer internship at the National Human Genomic Research Institute, Sappington conducted a third research project in which she demonstrated a fast, alignment - free computational method for identifying orthologs — similar genes from species that are related by descent from a common ancestoin which she demonstrated a fast, alignment - free computational method for identifying orthologs — similar genes from species that are related by descent from a common ancestor.

According to Andreassen, the study's senior author, some think of schizophrenia as a «side effect» arising from advantageous variants in genes that are related to the development of human traits, such as cognitive and language skills, that may have increased risks for developing psychoses.

Alterations in replication timing of cancer related genes in malignant human breast cancer cells.

Intracellular retention of the NKG2D ligand MHC class I chain - related gene A in human melanomas confers immune privilege and prevents NK cell - mediated cytotoxicity.

We focus on developing computational methods and tools for (a) analyzing large - scale gene expression data related to human cancer in search for gene markers and disease sub-categories, (b) identifying regulatory elements such as miRNA precursors and their targets in whole genomes of plants and mammals, (c) building theoretical models of gene regulatory networks.

To speed the identification of genes related to human diseases and to aid in the understanding of basic biological processes, the Howard Hughes Medical Institute (HHMI) and the Washington University...

Most recently, Dr. Gringeri was the Chief Operating Officer for Amsterdam Molecular Therapeutics (AMT), a Netherlands - based company engaged in human gene therapies for orphan diseases related to metabolic disorders, liver diseases, blood diseases, and disorders of the central and peripheral nervous systems.

In the current study, the researchers found that EBNA2 and its related transcription factors activate some of the human genes associated with the risk for lupus and several other autoimmune diseases, including multiple sclerosis, rheumatoid arthritis, inflammatory bowel disease, type 1 diabetes, juvenile idiopathic arthritis and celiac disease.

The effect of colonization of cdrA (cell division - related gene)- disrupted Helicobacter pylori to host response in human stomach.

Limb malformations are among the most common human birth defects, including the rare disorder Holt - Oram Syndrome, characterized by external shortened arms and hands and associated with defects in a gene closely related to Tbx4.

Potential projects include identifying common pathways that modify retinal degenerative disease from a large collection of actively maintained mouse models; determining molecular networks implicated in pathological disruption of the retinal pigment epithelium; identifying molecular pathways that regulate postnatal ocular growth; and using mouse models to assess the pathogenic role of gene variants that increase the risk of age - related macular degeneration as identified by human genome - wide association studies.

When he compared the genes in humans and gorillas, which are more distantly related, he noticed that the rate of evolution of maleness genes was still accelerated — but at a much slower rate in gorillas.

• In nutrigenomics, the basic goal is to discover how diet affects metabolic pathways in the body and how this regulation may be disturbed in diet - related disease — i.e., humans with a certain mutated gene absorb higher levels of fat from the intestine, leading to elevated cholesterol and possible atherosclerosiIn nutrigenomics, the basic goal is to discover how diet affects metabolic pathways in the body and how this regulation may be disturbed in diet - related disease — i.e., humans with a certain mutated gene absorb higher levels of fat from the intestine, leading to elevated cholesterol and possible atherosclerosiin the body and how this regulation may be disturbed in diet - related disease — i.e., humans with a certain mutated gene absorb higher levels of fat from the intestine, leading to elevated cholesterol and possible atherosclerosiin diet - related disease — i.e., humans with a certain mutated gene absorb higher levels of fat from the intestine, leading to elevated cholesterol and possible atherosclerosis.

Abbreviations: Aβ, amyloid β - peptide; AD, Alzheimer's disease; ALS, amyotrophic lateral sclerosis; Ambra1, activating molecule in Beclin -1-regulated autophagy; AMPK, AMP - activated protein kinase; APP, amyloid precursor protein; AR, androgen receptor; Atg, autophagy - related; AV, autophagic vacuole; Bcl, B - cell lymphoma; BH3, Bcl - 2 homology 3; CaMKKβ, Ca2 + - dependent protein kinase kinase β; CHMP2B, charged multivesicular body protein 2B; CMA, chaperone - mediated autophagy; 2 ′ 5 ′ ddA, 2 ′, 5 ′ - dideoxyadenosine; deptor, DEP - domain containing mTOR - interacting protein; DRPLA, dentatorubral pallidoluysian atrophy; 4E - BP1, translation initiation factor 4E - binding protein - 1; Epac, exchange protein directly activated by cAMP; ER, endoplasmic reticulum; ERK1 / 2, extracellular - signal - regulated kinase 1/2; ESCRT, endosomal sorting complex required for transport; FAD, familial AD; FDA, U.S. Food and Drug Administration; FIP200, focal adhesion kinase family - interacting protein of 200 kDa; FoxO3, forkhead box O3; FTD, frontotemporal dementia; FTD3, FTD linked to chromosome 3; GAP, GTPase - activating protein; GR, guanidine retinoid; GSK3, glycogen synthase kinase 3; HD, Huntington's disease; hiPSC, human induced pluripotent stem cell; hVps, mammalian vacuolar protein sorting homologue; IKK, inhibitor of nuclear factor κB kinase; IMPase, inositol monophosphatase; IP3R, Ins (1,4,5) P3 receptor; I1R, imidazoline - 1 receptor; JNK1, c - Jun N - terminal kinase 1; LC3, light chain 3; LD, Lafora disease; L - NAME, NG - nitro - L - arginine methyl ester; LRRK2, leucine - rich repeat kinase 2; MIPS, myo - inositol -1-phosphate synthase; mLST8, mammalian lethal with SEC13 protein 8; MND, motor neuron disease; mTOR, mammalian target of rapamycin; mTORC, mTOR complex; MVB, multivesicular body; NAC, N - acetylcysteine; NBR1, neighbour of BRCA1 gene 1; NOS, nitric oxide synthase; p70S6K, ribosomal protein S6 kinase - 1; PD, Parkinson's disease; PDK1, phosphoinositide - dependent kinase 1; PE, phosphatidylethanolamine; PI3K, phosphoinositide 3 - kinase; PI3KC1a, class Ia PI3K; PI3KC3, class III PI3K; PI3KK, PI3K - related protein kinase; PINK1, PTEN - induced kinase 1; PKA, protein kinase A; PLC, phospholipase C; polyQ, polyglutamine; PS, presenilin; PTEN, phosphatase and tensin homologue deleted from chromosome 10; Rag, Ras - related GTP - binding protein; raptor, regulatory - associated protein of mTOR; Rheb, Ras homologue enriched in brain; rictor, rapamycin - insensitive companion of mTOR; SBMA, spinobulbar muscular atrophy; SCA, spinocerebellar ataxia; SLC, solute carrier; SMER, small - molecule enhancer of rapamycin; SMIR, small - molecule inhibitor of rapamycin; SNARE, N - ethylmaleimide - sensitive factor - attachment protein receptor; SOD1, copper / zinc superoxide dismutase 1; TFEB, transcription factor EB; TOR, target of rapamycin; TSC, tuberous sclerosis complex; ULK1, UNC -51-like kinase 1; UVRAG, UV irradiation resistance - associated gene; VAMP, vesicle - associated membrane protein; v - ATPase, vacuolar H + - ATPase; Vps, vacuolar protein sorting

Kaghad M, Bonnet H, Yang A, Creancier L, Biscan JC, Valent A, Minty A, Chalon P, Lelias JM, Dumont X, Ferrara P, McKeon F, Caput D. Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers.

The Human Organ - specific Molecule Electronic Repository (Homer) is a comprehensive database covering about 22809 genes / proteins detailed in and filtered from expression and disease - related databases such as, dbEST, TiSGeD, human plasma proteins (HPA), The Comparative Toxicogenomics Database (CTD) and Disease OntoHuman Organ - specific Molecule Electronic Repository (Homer) is a comprehensive database covering about 22809 genes / proteins detailed in and filtered from expression and disease - related databases such as, dbEST, TiSGeD, human plasma proteins (HPA), The Comparative Toxicogenomics Database (CTD) and Disease Ontohuman plasma proteins (HPA), The Comparative Toxicogenomics Database (CTD) and Disease Ontology.