Not exact matches
«Our research suggests that such variants may have piggybacked onto positively selected
regions, which were also enriched
in disease -
related genes,» Lohmueller said.
They found many of the 131
regions were
related to
genes involved
in growth and development and cellular function and maintenance.
Consistent with that result, the researchers found that certain
regions of the X chromosome
in human female B cells, including
regions that contain immunity -
related genes, were expressed at higher levels than male cells.
In one species, the black snub - nosed monkey (about 2,000 individuals are found in the wild), they identified several hypoxia - related genes that allowed them to thrive in the highest altitudes (a narrow region 3,400 - 4,500 meters above sea level in a narrow region between the Yangtze and Mekong rivers within the Tibetan plateau) than any other nonhuman primat
In one species, the black snub - nosed monkey (about 2,000 individuals are found
in the wild), they identified several hypoxia - related genes that allowed them to thrive in the highest altitudes (a narrow region 3,400 - 4,500 meters above sea level in a narrow region between the Yangtze and Mekong rivers within the Tibetan plateau) than any other nonhuman primat
in the wild), they identified several hypoxia -
related genes that allowed them to thrive
in the highest altitudes (a narrow region 3,400 - 4,500 meters above sea level in a narrow region between the Yangtze and Mekong rivers within the Tibetan plateau) than any other nonhuman primat
in the highest altitudes (a narrow
region 3,400 - 4,500 meters above sea level
in a narrow region between the Yangtze and Mekong rivers within the Tibetan plateau) than any other nonhuman primat
in a narrow
region between the Yangtze and Mekong rivers within the Tibetan plateau) than any other nonhuman primate.
Finding MODY3 led to the rapid discovery of MODY1, a functionally
related gene known as HNF -4-alpha, which had been mapped to the MODY1 -
region of chromosome 20 by Markus Stoffel, MD, Rockefeller University, a collaborator
in the search for MODY1 since 1991.
Kaghad M, Bonnet H, Yang A, Creancier L, Biscan JC, Valent A, Minty A, Chalon P, Lelias JM, Dumont X, Ferrara P, McKeon F, Caput D. Monoallelically expressed
gene related to p53 at 1p36, a
region frequently deleted
in neuroblastoma and other human cancers.
Both studies generated interesting results
relating to the DNA
region in which the HAS2
gene is located.
Pollinger et al., [44] identified a 40 Mb selective sweep on CFA11 associated with black coat color
in Large Munsterlander and a 10 MB
region on CFA3
in Dachshund containing FGFR3, which is responsible for achondroplasia
in humans and presumably linked with
related genes responsible for canine chondrodysplasia.
CEA, which segregates
in several herding breeds with Collie ancestry, was mapped to a large
region of CFA37 that included over 40
genes [92]; subsequently the fact that the disorder segregates
in multiple, closely
related breeds was used to reduce the size of the critical disease - associated
region and pinpoint the causal mutation to a 7.8 kb intronic deletion
in the NHEJ1
gene, which spans a highly conserved binding domain to which several developmentally important
genes bind [91].
Having evolved
in a
region with less climate variability over both the years and the millennia, tropical species may harbor a less diverse set of
genes related to heat tolerance and similar traits.
Serotonin transporter
gene regulatory
region polymorphism and anxiety -
related traits
in the Japanese
Allelic variation
in this transporter's
gene expression, regulated by a 43 bp indel
in the upstream
region termed 5 - HTTLPR, was initially associated with anxiety -
related traits (23) and has since been investigated
in many fields of serotonin -
related human genetics (24).