Sentences with phrase «related genes lead»

If it does, they will be able to use the animals to study how those delay discounting - related genes lead to those behaviors, at a molecular level.

Not exact matches

Downstream of the signaling system, Runx2 overexpression led to overexpression of bone - related genes, including genes expressed by osteoblasts, osteoclasts and osteocytes.

The discovery, made possible through a combination of cutting - edge stem cell and gene - editing technologies, could lead to ways of countering age - related physiological declines by preventing or reversing damage to heterochromatin.

To test this hypothesis, an international team led by evolutionary biologist Philipp Khaitovich of the Shanghai Institutes for Biological Sciences in China and the Max Planck Institute for Evolutionary Anthropology in Leipzig, Germany, set out to see how many brain - related genes implicated in schizophrenia underwent positive natural selection since humans and chimpanzees diverged from a common ancestor between 5 million and 7 million years ago.

Dorothy Romanus, lead author of the study, states «this analysis supports the value of multiplexed testing for EGFR and ALK gene rearrangements followed by molecularly - guided therapy in decisions surrounding coverage of related testing and targeted therapy.

Links between genetics and mental illness led to several major discoveries this year: Researchers at Myriad Genetics in Salt Lake City reported finding a gene related to depression, and researchers at the University of California at San Diego found a flawed gene linked to manic depression.

The other team, led by medical psychologist Julie Williams of Cardiff University in Wales, noted the same CLU gene and identified another Alzheimer's - related gene, PICALM.

Although BRAF gene fusions were well known to be involved in PLGGs, the study team found important differences in a related gene, CRAF, in which mutations can also lead to this type of glioma.

This led Lippman's team to propose that the ancient function of the HPAT genes is to control tip growth, which, Lippman says, is likely related to key proteins that are critical for forming cell walls.

«We observed that a large number of genes were involved in pathways related to wound healing, immunity, and metabolism, and this is consistent with the idea that the earliest stages of domestication may involve adapting to highly crowded conditions,» said Mark Christie, lead author of the study.

CRC is the second - leading cause of cancer - related deaths in the United States, and about 70 percent of CRC patients in this study have tumors without mutations in the KRAS gene.

The search for autism - related genes has led to stunning evidence of the complexity of the disease, which is estimated to affect one in every 150 children born worldwide.

In the new study, a team led by molecular ecologist Silke Steiger and her graduate adviser Bart Kempenaers at the Max Planck Institute for Ornithology in Starnberg, Germany, searched for smell - related genes in nine species representing seven major branches of the avian family tree.

SAN FRANCISCO, CA — A scientific team led by the Gladstone Institutes and UC San Francisco has discovered that a common form of a gene already associated with long life also improves learning and memory, a finding that could have implications for treating age - related diseases like Alzheimer's.

The symposium features presentations by Philippa Marrack and John Kappler talking on the T cell repertoire; William Paul on interleukin 4 as a prototypic immunoregulatory cytokine; Timothy Springer on lymphocyte trafficking; Pamela Bjorkman on structural studies of MHC and MHC - related proteins, and Jack Strominger on peptide presentation by class I and II MHC proteins; Thierry Boon on genes coding for tumor rejection antigens, including the first tumor antigen, MAGE - 1; and Philip Greenberg on the modification of T cells for adoptive therapy by retroviral - mediated gene insertion Since then, the symposia series has attracted leading immunologists in the cancer vaccine and antibody fields, providing them with a comprehensive view of the promises and challenges in the development of cancer immunotherapies.

ISIS - SMNRx is designed to treat all types of childhood SMA by altering the splicing of a closely related gene (SMN2) that leads to the increased production of fully functional SMN protein.

Surveillance that is not stringent enough, on the other hand, would allow eggs with a lot of jumping gene - related errors to survive, and lead to a high level of birth defects, such as those caused by an incorrect number of chromosomes in the offspring.

Finding MODY3 led to the rapid discovery of MODY1, a functionally related gene known as HNF -4-alpha, which had been mapped to the MODY1 - region of chromosome 20 by Markus Stoffel, MD, Rockefeller University, a collaborator in the search for MODY1 since 1991.

The Haematological Cancer Genetics team, led by George Vassiliou, studies the genes and genetic pathways involved in the development of blood cancers, with a particular emphasis on Acute Myeloid Leukaemia and related malignancies.

Howard Hughes Medical Institute (HHMI) researchers have identified subtle defects in a single gene that underlie a hereditary form of age - related macular degeneration, the leading cause of...

This research will hopefully lead to new insights about diseases and disorders that relate to gene expression.

This demonstrated that only TGFB1 ‐ related genes correlated with the DNA methylation differences, leading to an over expression of such genes.

A research team led by Masashi Yanagisawa, director of the International Institute for Integrative Sleep Medicine (IIIS) at the University of Tsukuba, believes the differing tendencies could stem from mutations of particular genes relating to sleep.

• In nutrigenomics, the basic goal is to discover how diet affects metabolic pathways in the body and how this regulation may be disturbed in diet - related disease — i.e., humans with a certain mutated gene absorb higher levels of fat from the intestine, leading to elevated cholesterol and possible atherosclerosis.

Some of the concerns raised about somatic gene transfer are related to the possibility that it could inadvertently lead to germline gene transfer.

It is likely that a combination of several factors (e.g. age - related changes at the level of gene expression, infectious agents, toxic compounds, and head trauma) affects the neuronal milieu and initiates neuropathological processes leading to the formation of toxic tau and amyloid β species, reduction of synaptic plasticity, and neuronal loss resulting in development of sporadic AD.»