Sentences with phrase «related genes through»

Not exact matches

Friedenson thinks that cancer - related viruses that are normally harmless can become dangerous if genes involved in immunity are mutated, either through heredity or environmental causes.

The discovery, made possible through a combination of cutting - edge stem cell and gene - editing technologies, could lead to ways of countering age - related physiological declines by preventing or reversing damage to heterochromatin.

Less clear is how this misfolding relates to the growing number of genes implicated in PD through analysis of human genetics.

This analysis produced networks that mapped out how alpha - synuclein is related to other Parkinson's genes through well - defined molecular pathways.

In Class II engagement, Sox9 binds to multiple active enhancer elements through sub-optimal, low - affinity Sox dimeric motifs (DNA sequences), resulting in a high level of transcription of cartilage - related genes.

Based on a list of about 30 disease - related DNA targets that researchers are interested in altering through gene editing, the researchers made a second list of nearly 3,000 guide RNAs (gRNAs).

Through blood samples of the participants, epigenetic markers in the form of DNA methylation in the stress system - related genes were analysed.

So his team sifted through genetic information from 45,000 microbes, flagging groups of genes with unknown functions that were located near known defense - related genes.

Changes in BabA binding properties, through mutation and recombination with BabA - related genes, evolve due to differences between individual hosts and changes in gastric acidity over time.

Indeed, human pluripotent stem cell lines and derivatives, which express a disease - related mutated gene, represent a relevant and pertinent disease cell model to analyse pathological mechanisms through large - scale drug screenings.

They describe gene therapy administered through skin transplants to treat two related and extremely common human ailments: type - 2 diabetes and obesity.

The uPA gene is related to PAI - 1, also in this list, and is argued to achieve life extension in mice through behavioral change - these mice eat less, and thus the calorie restriction response comes into play.

«The two plants are genetically related and the fear is that through gene flow, johnsongrass can pick up traits from sorghum,» Bagavathiannan said.

This is in accordance with previous reports that decitabine and 5 - azacytidine produce a marked synergistic effect in combination with suberoylanilide hydroxamic acid and romidepsin in T - lymphoma cell lines by modulating cell cycle arrest and apoptosis.26, 27 As a mechanism of action, KMT2D mutations of B - lymphoma cells promote malignant outgrowth by perturbing methylation of H3K4 that affect the JAK - STAT, Toll - like receptor, or B - cell receptor pathway.28, 29 Here our study indicated that dual treatment with chidamide and decitabine enhanced the interaction of KMT2D with the transcription factor PU.1, thereby inactivating the H3K4me - associated signaling pathway MAPK, which is constitutively activated in T - cell lymphoma.13, 30,31 The transcription factor PU.1 is involved in the development of all hematopoietic lineages32 and regulates lymphoid cell growth and transformation.33 Aberrant PU.1 expression promotes acute myeloid leukemia and is related to the pathogenesis of multiple myeloma via the MAPK pathway.34, 35 On the other hand, PU.1 is also shown to interact with chromatin remodeler and DNA methyltransferease to control hematopoiesis and suppress leukemia.36 Our data thus suggested that the combined action of chidamide and decitabine may interfere with the differentiation and / or viability of PTCL - NOS through a PU.1 - dependent gene expression program.

Recently, some other cytokines (such as tumor necrosis factor) or chemical drugs were also found to up - regulate several IFN - inducible gene family members (including RIG - G) through production of type I IFNs (37, 38), further indicating that the induction of RIG - G by ATRA in NB4 cells was tightly related with an IFNα autocrine pathway.

Although the mechanism of age - related decline in DNA repair capacity is unknown, growing evidence suggests that epigenetic events (e.g., DNA methylation) contribute to the ageing process and may be functionally important through the regulation of the expression of DNA repair genes.

Scouring through thousands of base pairs around this gene, the researcher found distinct enhancer elements relating to each location.

We found out when we examined genes that quite often we could find evidence that one gene had given the path of its sequence to another related gene, so it was as if there were two genes and one said, «I'm not going through, the New York business,» and the other one said the slightly different message, and yet they exchanged information.

To understand the selection mechanism behind mutations, network - based studies were used to estimate the importance of a mutated protein compared to non-mutated ones in signalling and protein — protein interaction networks.10, 11,12,13 Proteins mutated in cancer were found having a high number of interacting partners (i.e., a high degree of connectivity), which indicates high local importance.10 Mutated proteins are also often found in the centre of the network, in key global positions, as quantified by the number of shortest paths passing through them if all proteins are connected with each other (i.e., they have high betweenness centrality; hereafter called betweenness).11, 12 Mutated proteins also have high clustering coefficients, which means their neighbours are also neighbours of each other.10, 13 Moreover, neighbourhood analysis of mutated proteins have been previously successfully used to predict novel cancer - related genes.14, 15 However, to the best of our knowledge, no study has concentrated particularly on the topological importance of first neighbours of mutated proteins in cancer, and their usefulness as drug targets themselves.

The clinical study from OSUWMC proved that PrimaVie promoted skeletal muscle adaptation through upregulation of ECM - related genes that control muscle mechanotransduction properties, elasticity, repair, and regeneration.

Finally, animal research focusing on brain - structural aspects related to early care and the new, conceptually important direction of studying environmental programming of early development through epigenetic modification of gene functioning is examined in brief.