Sentences with phrase «related immune diseases»

AllerGen — part of the federally funded Networks of Centres of Excellence program — aims to help Canadians address the challenges of living with asthma, allergies, anaphylaxis and related immune diseases.

Not exact matches

The psoriasis field is among the most lucrative (if not the most lucrative) in biopharma, thanks to a combination of a massive patient pool and the ways in which these treatments can extend to somewhat related immune and inflammatory conditions, like arthritis and Crohn's disease.

This grain's health benefits include managing blood - sugar levels, maintaining weight, preventing colon disease, strengthening bones, improving the immune system, and supporting those with celiac related diseases.

The team identified 345 regions of the genome where they could pinpoint the likely molecular causes underlying a person's predisposition to immune - related diseases such as inflammatory bowel disease, type 1 diabetes and multiple sclerosis.

While abnormal immune responses are largely responsible for these diseases, issues relating to gut microbiome, intestinal epithelial cells, immune components and the gut's rhythmic peristalsis motions can also contribute to and exacerbate symptoms.

Others are trying to reduce overzealous immune responses that take their toll through inflammation - related ailments like heart disease, arthritis, Alzheimer's disease, and cancers.

Eye diseases — such as age - related macular degeneration, as well as a genetic condition called Stargardt's macular dystrophy that afflicts young people — are considered excellent candidates for stem cell therapy because the eye is an immune - privileged site, meaning transplanted cells are not as likely to be rejected as foreign compared with transplants elsewhere.

To understand what was unique about the LAD patients» disease, the researchers examined their immune system - related genes and proteins.

The team used DNA genotyping technology to survey more thoroughly regions of the genome known to underlie other immune - related diseases to discover if they also play a role in PSC susceptibility.

«This study extends the narrative that many of the effects of disease - related genetic variation are specific to a certain context, such as a given immune cell type,» said Barbara Stranger, PhD, University of Chicago, senior study author.

Boehringer Ingelheim is actively involved in research related to such conditions as cardiovascular, metabolic and respiratory diseases, cancer, AIDS, hepatitis C, and diseases mediated by the immune system.

Monitoring immune responses by measuring cytokine levels has become an integral part of disease - related research, providing clues to the state of the immune system and how it could be targeted therapeutically.

Patients receiving abatacept had intact immune reconstitution, significant improvement in transplantation - related mortality, no major uncontrolled infection and no increase in disease relapse.

Our knowledge of immune - related pathologies in the brain and the ability to identify biomarkers for disease and inflammation are key for forming meaningful mechanistic conclusions.

The mice with age - related disease, they found, had abnormally high levels of immune cells called T regulatory cells (Tregs) inside their fat tissue.

That finding suggests that the immune - related genes of the ancient Tsimshian were well - adapted to local diseases but not to novel infections like smallpox and measles, the team reports today in Nature Communications.

Together with research into other immune - related genes in diseases such as Alzheimer's, the idea that immune processes are involved in some psychiatric phenotypes is looking ever more solid.

Families had to respond to an extensive questionnaire covering the child's home environment, contact with animals, diet and family predisposition to immune related diseases, such as allergies.

The 2 percent distinction also involves an unusually large fraction of genes related to the immune system, parasite vulnerability, and infectious diseases: Chimps are resistant to malaria, and we aren't; we handle tuberculosis better than they do.

We can protect ourselves against aging - related cognitive decline, prolong the vivacity of our immune systems, strengthen our bones, and empower our mitochondria, as well as reduce our risk of cardiovascular diseases, diabetes, neurodegenerative diseases, and certain cancers.

«We have long known that an activated immune system and a defective skin barrier are both important factors in eczema, but not how they are related and which one drives the disease,» said Dr. Leung.

The study, published in Cell, suggests these antibodies could limit immune - related diseases and may have therapeutic potential.

- In a study with potentially major implications for the future treatment of autoimmunity and related conditions, scientists from the Perelman School of Medicine at the University of Pennsylvania have found a way to remove the subset of antibody - making cells that cause an autoimmune disease, without harming the rest of the immune system.

First of all, the immune response to Lyme disease appears to be strongly age - related.

Potential new approaches to treating eye diseases such as age - related macular degeneration (AMD) are described in a new study, «IL - 33 amplifies an innate immune response in the degenerating retina,» in the February Journal of Experimental Medicine.

The fact that the association was particularly strong in those with no siblings suggests it may be related to the «hygiene hypothesis» — the idea that exposure to mild infections in childhood, which might be more numerous with more siblings, are important to immune system development and may reduce the risk of immune - related diseases.

Professor David Lambert, Professor of Anaesthetic Pharmacology from the University of Leicester's Department of Cardiovascular Sciences and Leicester's Hospitals said: «I have been working on the pain related and immune modulatory actions of nociceptin for many years and it is really exciting to see this translated into a further therapeutic arena; the devastating airways disease of asthma.»

But this defense system can also be inappropriately activated and attack cells, contributing to a broad spectrum of immune, inflammatory, and age - related diseases.

While translational research has traditionally moved basic immunology knowledge forward into clinical application, varying clinical presentations of human immune - related disease processes, as well as variability in therapeutic outcomes, have provided opportunities for discovery of novel mechanistic hypotheses directly from patients.

However, the great majority of our work in this area is related to the development of inflammatory bowel diseases (IBD), immune - mediated diseases of the intestine that include Crohn's disease and ulcerative colitis.

In recent years, researchers have developed so - called «senolytic» drugs that wipe out senescent cells in aging mice and mouse models of age - related disease, exploiting the high dependence of these cells on specific biochemical survival pathways.9, 10 In these studies, senolytic drugs have restored exercise capacity9 and formation of new blood and immune precursor cells11 in aging mice to near youthful norms, and prevented or treated mouse models of diseases of aging like osteoarthritis, 12 fibrotic lung disease, 13 hair loss, 14 atherosclerosis, 15,16 and age - related diseases of the heart itself.9 UNITY Biotechnology is leading a growing charge toward the clinic, with human clinical trials expected to begin in 2019.

It is based on the scientific understanding and high - throughput analyses of human immune responses to disease - related proteins in selected populations including elderly with the capability to stay healthy during the aging process.

BUFFALO, New York, July 6, 2016 — A research team from Everon Biosciences, Inc. and Roswell Park Cancer Institute has identified a specific subpopulation of immune cells accumulating in old mice that are likely contributors to aging and age - related diseases.

PULLMAN, Wash. — A class of drugs used to treat parasitic infections such as malaria may also be useful in treating cancers and immune - related diseases, a new WSU - led study has found.

Newly identified genetic risk variants for celiac disease related to the immune response.

In a pioneering study, he applied these tools to a genome - wide study of disease - related changes in the epigenome — the layer atop the genome that controls gene activity and is altered by the environment — of immune cells isolated from patients with asthma.

Interferon signaling is central to the innate immune system, so answers to these questions also can lead to better understanding of cancers and diseases and new drugs related to immune activity or malfunction.

Our objective is to generate a resource that facilitates research into human immune - related diseases by creating a comprehensive database of cell type - and allele - specific epigenomic and transcriptomic data for the immunology community.

AIDS - affected people are more susceptible to water - related diseases than healthy individuals, and they become sicker from these infections than people with healthy immune systems.

They are linked to male and female reproductive disorders, obesity, diabetes, neurological problems, immune and thyroid disorders, osteoporosis, Parkinson's disease, and hormone - related cancers.

Allergies or asthma, type 1 diabetes, lupus, cancer, arthritis, inflammatory bowel disease, MS, heart disease and Alzheimer's disease are just a few examples of immune - related conditions that cause pain, suffering, debilitation, and even shortened lifetimes.

We all know someone, perhaps a close relative or friend whose health has suffered because of a disease related to the immune system, although in some cases the disease names may be unfamiliar, or the immune system as an underlying cause may not be widely appreciated.

Every day, our researchers work towards making discoveries that will lead to better preventions, therapies, and ultimately cures for immune system - related diseases, as well as working for ways to improve the vaccines that the world so desperately needs.

This is known to be related to digestive conditions like irritable bowel disease and intestinal permeability, which is now being linked to immune system dysfunction.

«These findings related to Crohn's disease are similar to previous reports focused on other autoimmune conditions like multiple sclerosis confirming that the delicate balance of our immune systems is, to a great extent, dictated by organisms making up our microbiome,» said Dr. David Perlmutter, expert on brain and gut health, and author of Grain Brain.

«What makes it an autoimmune disease is the fact that the immune system is producing antibodies against your own tissue,» explains longtime patient advocate Virginia T. Ladd, president and executive director of the American Autoimmune Related Diseases Association (AARDA).

Ageing is just a natural process that might show up at any age and which is reflected not only by the modifications in our body appearance, but more importantly by the internal signs proving a gradual deterioration in our inner body ability to ensure an optimal metabolism and physiology, to keep a strong immune system and consequently to prevent and fight the chain of degenerative chronic diseases, also called age - related diseases.

A diet high in saturated and trans fats and low in antioxidants can damage blood vessel walls to cause an immune response related to inflammation and the development of cardiovascular ailments.8, 9,10 Low - grade inflammation in older individuals has been shown to contribute to fat accumulation, insulin resistance, and inflammatory - related diseases.11

Alcohol can have a strong impact on the production of oxidative stress, because it is not metabolized in the liver — leading to alcoholic liver disease.6, 7 The development of oxidative stress is also related to smoking, which suppresses the immune response and damages lung function.8 What may seem like a surprising factor is the use of pharmaceutical drugs and radiation.

In recent years, the importance of the gut microbiota has come more clearly into the picture as playing an important role in immune - related diseases, and even in regulating predisposition...