Sentences with phrase «related signaling mechanisms»

unraveling phosphorylation - related signaling mechanisms associated with cell division and differentiation in plants

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«Disruption or enhancement in such signaling is often directly related to disease mechanism and can be targeted for therapy,» Carr said.

In particular, he demonstrated that alcohol dependence is associated with robust and persistent increases in the hydrolytic clearance of 2 - AG that prevents stress - related elevations in 2 - AG signaling that normally contribute to coping mechanisms that stabilize affective state.

Pharmacological data with acute or intermittent ketamine treatment as well as compounds targeting more traditional mechanisms related to 5 - HT or adrenergic signaling will also be presented for these models.

Besides lipotoxicity (see section V.N) many other molecular mechanisms are involved, including mitochondrial dysfunction, oxidative stress, intramyocardial inflammation, involvement of the reninangiotensin system, altered insulin signaling or female - specific cardiac glycogen handling as a response to metabolic stress (308), and sex - hormone related myocardial calcium handling (309).

Pathological changes in the brain were observed, and the expressions of brain - derived neurotrophic factor (BDNF) and extracellular signal - related kinase (ERK1 / 2) were determined to explore the mechanism of BB extract - induced benefits.

This is in accordance with previous reports that decitabine and 5 - azacytidine produce a marked synergistic effect in combination with suberoylanilide hydroxamic acid and romidepsin in T - lymphoma cell lines by modulating cell cycle arrest and apoptosis.26, 27 As a mechanism of action, KMT2D mutations of B - lymphoma cells promote malignant outgrowth by perturbing methylation of H3K4 that affect the JAK - STAT, Toll - like receptor, or B - cell receptor pathway.28, 29 Here our study indicated that dual treatment with chidamide and decitabine enhanced the interaction of KMT2D with the transcription factor PU.1, thereby inactivating the H3K4me - associated signaling pathway MAPK, which is constitutively activated in T - cell lymphoma.13, 30,31 The transcription factor PU.1 is involved in the development of all hematopoietic lineages32 and regulates lymphoid cell growth and transformation.33 Aberrant PU.1 expression promotes acute myeloid leukemia and is related to the pathogenesis of multiple myeloma via the MAPK pathway.34, 35 On the other hand, PU.1 is also shown to interact with chromatin remodeler and DNA methyltransferease to control hematopoiesis and suppress leukemia.36 Our data thus suggested that the combined action of chidamide and decitabine may interfere with the differentiation and / or viability of PTCL - NOS through a PU.1 - dependent gene expression program.

In fact, because many mechanisms of aging are broadly conserved across animals, including Drosophila, research on the signaling networks that regulate this process could eventually have profound impacts on the treatment of age - related diseases like Alzheimer's.

The advanced understanding of the mechanisms underlying Oligophrenin1 - related ID, allowed us to develop a therapeutic approach targeting the RHOA / ROCK signalling pathway and repurpose Fasudil - a well - tolerated ROCK and PKA inhibitor - as a treatment of ID.

To understand the selection mechanism behind mutations, network - based studies were used to estimate the importance of a mutated protein compared to non-mutated ones in signalling and protein — protein interaction networks.10, 11,12,13 Proteins mutated in cancer were found having a high number of interacting partners (i.e., a high degree of connectivity), which indicates high local importance.10 Mutated proteins are also often found in the centre of the network, in key global positions, as quantified by the number of shortest paths passing through them if all proteins are connected with each other (i.e., they have high betweenness centrality; hereafter called betweenness).11, 12 Mutated proteins also have high clustering coefficients, which means their neighbours are also neighbours of each other.10, 13 Moreover, neighbourhood analysis of mutated proteins have been previously successfully used to predict novel cancer - related genes.14, 15 However, to the best of our knowledge, no study has concentrated particularly on the topological importance of first neighbours of mutated proteins in cancer, and their usefulness as drug targets themselves.

Rigel Pharmaceuticals focuses on intracellular signaling pathways and related targets that are critical to disease mechanisms.