This work shows that TREM2 is important not just in
the relatively small number of patients carrying mutations, but potentially in all of Alzheimer's.»
The USIDNET registry gathers variables including clinical, laboratory and outcome data, which together provide a health survey of
the relatively small number of patients affected by primary immunodeficiency disorders.
Guideline authors noted, however, that the evidence for the recommendations is weak, since many of the studies had
relatively small numbers of patients with similar types of epilepsy and were conducted at only one institution, so the results may not be generalizable to everyone with epilepsy.
«We look for activity of our molecules in phase 2, and on numerous occasions we generate statistically significant data with
relatively small numbers of patients, which gives us reasonable confidence that the program will be successful in phase 3 with a larger group of patients.
However, due to
relatively small numbers of patients within sub-groups, the researchers caution that they did not find definitive evidence to show that effects of vitamin D supplementation differ according to baseline vitamin D status.
Not exact matches
If it works, it could be used in a far greater
number of patients than Sarepta's drug, which is approved for a
relatively small slice
of the DMD
patient pool.
David Magnus, PhD, director
of the Stanford Center for Biomedical Ethics and professor
of medicine and
of biomedical ethics, said those concerns resonate beyond treating SMA
patients, who represent a
relatively small group
of people, because competition is fierce for resources to treat
patients with any
number of illnesses for which new and more expensive treatments are emerging.
Researchers have found that just five strains are overwhelmingly the culprits in more than 3000 samples
of resistant S. aureus collected from
patients around the world; the
small number suggests that
relatively few strains can easily develop resistance to antibiotics, allowing scientists to focus on these few and determine what makes them so virulent.
In the first trial (Neurology 2007; 68:51 — 55), 12 weeks
of phenylbutyrate treatment produced no beneficial effects, although the
small number and
relatively large age range
of the
patients may have hidden a modest effect.
Although the trial was
relatively small in terms
of the
number of patients, it was unusually rigorous in the methods used to analyze heart metabolism, according to Gropler.
Despite their
small number, the
patients had a
relatively consistent pattern
of clinical features suggesting the presence
of a QRICH1 - associated phenotype.
The biggest reality check
of all, however, is that the
number of cancers immunotherapy has been proven effective for is still
relatively small (though growing)-- and it doesn't work on every
patient.
It is at present unknown whether an optimal balance between safety and efficacy can be achieved with the combination therapy
of GH and IGF - I, since this combination has been evaluated in only a
small number of patient populations and in studies
of a
relatively short duration.
By the way, I think the reason the cardiovascular problems were not clearly revealed in clinical trials was that the
relatively limited
number of patients was too
small to provide conclusive statistical evidence
of an association.