Sentences with phrase «releasing factor»

A group of cells releases a factor, which changes gene expression in a related group of cells.

The opiate - like peptide beta - endorphin and adrenocorticotropin are concomitantly secreted in increased amounts by the adenohypophysis in response to acute stress or long - term adrenalectomy as well as in vitro in response to purified corticotropin releasing factor and other secretagogues.

Two analogs of the hypothalamic luteinizing hormone releasing factor modified at the histidine - 2 position were tested for biological activity (secretion of luteinizing hormone) in cultures of dispersed rat anterior pituitary cells.

Impaired growth hormone responses to growth hormone - releasing factor in obesity.

Persistent changes in corticotropin - releasing factor neuronal systems induced by maternal deprivation.

The new study also found that the fly version of the human brain protein known as corticotrophin releasing factor (CRF) is a major coordinating molecule in this circuit.

C. WT astrocytes release factors that are sufficient to rescue the phenotype of ASD neurons.

Basically there are two different types of GH Releasing Peptides the GRF or Growth Releasing Factor and Growth Hormone Releasing Peptides or GHRP - 2.

Early life adversity and serotonin transporter gene variation interact to affect DNA methylation of the corticotropin - releasing factor gene promoter region in the adult rat brain

Childhood trauma and personality disorder: Positive correlation with adult CSF corticotropin - releasing factor concentrations

Upon stalling, two conserved residues within the peptidyltransferase center adopted conformations that preclude binding of release factors.

The presence of synthetic ovine corticotropin - releasing factor leads to a rapid and marked stimulation of adenosine 3», 5» - monophosphate accumulation in an enriched population of rat pituitary corticotrophs in primary culture.

The tumor - derived peptide is identical in biological activity and similar in physiochemical properties to the still uncharacterized growth hormone - releasing factor present in extracts of hypothalamic tissues.

Monoclonal antibodies to hypothalamic growth hormone - releasing factor with picomoles of antigen

Corticotropin - releasing factor stimulates accumulation of adenosine 3», 5» - monophosphate in rat pituitary corticotrophs

The first was the idea of using a genomically recoded organism of Escherichia coli bacteria that lacked release factor 1.

The antibodies release the factor 8 molecules when doused in a solution of a specific acidity.

More of both support cell suicide as now sick or injured cells signal mitochondria to release factors such as cytochrome c into the cell cytoplasm.

Corticotropin - releasing factor receptor -2-deficient mice display abnormal homeostatic responses to challenges of increased dietary fat and cold.

Once taken up by antigen - presenting cells, which help focus the immune system on an invader, the vaccine releases a factor that heightens their attention specifically to the cancer - promoting protein E7, a so - called oncoprotein that not only enables the human papillomavirus to multiply, but potentially cervical cancer cells to do the same.

Visceral fat releases factors that promote inflammation.

Soil organic matter loss, CO2 release factors and mitigation measures have been identified in the following studies.

Several scientists at the institute are experimenting with a peptide called alpha helical corticotropin releasing factor.

Instead, they contain artificially - created human growth hormone releasing factor, or HGHRF.

Persistent changes in corticotropin - releasing factor neuronal systems induced by maternal deprivation

Amygdala PKC epsilon regulates corticotrophin releasing factor, anxiety - like behavior and alcohol consumption Heidi Lesscher, University Medical Center Utrecht, The Netherlands

D. ASD astrocytes release factors that are sufficient to impair the development of WT neurons.

Early life adversity and serotonin transporter gene variation affect DNA methylation of the corticotropin - releasing factor gene promoter region in the adult rat brain

Persistent elevations of cerebrospinal fluid concentrations of corticotropin - releasing factor in adult nonhuman primates exposed to early - life stressors: Implications for the pathophysiology of mood and anxiety disorders

The analog in which glycine was substituted for histidine at position 2, [Gly2] LRF, behaves as a partial agonist releasing less than 50 percent of the luteinizing hormone secreted at maximum concentrations of the releasing factor, while the analog in which histidine at position 2 is deleted has no significant agonist activity at any of the doses tested.

When added to the cultured cells at molar ratios 103 to 104 times that of the luteinizing hormone releasing factor, both analogs decrease the amount of luteinizing hormone secreted in response to the releasing factor.

Synthetic Polypeptide Antagonists of the Hypothalamic Luteinizing Hormone Releasing Factor

The increase, observed as early as 60 seconds after the addition of corticotropin - releasing factor, suggests that changes in the intracellular concentration of the cyclic nucleotide coincide with or precede the secretion of adrenocorticotropic hormone in response to corticotropin - releasing factor.

Hybridoma supernatants were screened for anti-rGRF activity by use of a pituitary culture assay system that can detect growth hormone - releasing factor in the femtomole range.

Monoclonal antibodies specific for rat hypothalamic growth hormone - releasing factor (rGRF) have been produced by in vitro immunization of mouse spleen cells with less than 1 nanomole of rGRF in a partially purified preparation.

Young's team has also shown that blocking corticotropin - releasing factor (CRF), a hormone involved in the stress response, stops the depressive behaviour that prairie voles exhibit when their partner dies.

The direct application of insulin to primary cultures of the anterior pituitary did not evoke ACTH release or affect the maximal ability of corticotropin - releasing factor or epinephrine to stimulate ACTH secretion.

Specifically, the release of a stress - coping hormone called corticotropin - releasing factor (CRF), which is widely found in the brain and acts as a neurotransmitter / neuromodulator, is dysregulated in AD and is associated with impaired cognition and with detrimental changes in tau protein and increased production of amyloid - beta — protein fragments that clump together and trigger the neurodegeneration characteristic of AD.

When this happens, a release factor binds and triggers the release of the peptide chain, so it can be folded into a protein.

Hypothalamus: The brain's stress responder, the hypothalamus, shows boosts in corticotropin - releasing factor and adrenocorticotropic hormone in germ - free mice.

Our anxiety is connected to hormones in the brain called corticotropin - releasing factors or CRFs, which regulate stress and appetite.

In addition, other hormones, including corticotropin - releasing factor, vasoactive intestinal peptide, and arginine vasopressin stimulate while the corticosteroids and somatostatin inhibit adrenocorticotropin secretion.

The federally funded study, published in the Journal of Leukocyte Biology, showed how a stress receptor, known as corticotropin - releasing factor, or CRF1, can send signals to certain immune cells, called mast cells, and control how they defend the body.

This peptide, called corticotropin - releasing factor (CRF), is associated with anxiety and depression.

The Contet laboratory aims to identify the source of corticotropin - releasing factor (CRF) being released in the central nucleus of the amygdala during ethanol withdrawal.

Corticotropin releasing factor - induced amygdala gamma - aminobutyric acid release plays a key role in alcohol dependence.

Corticotropin - releasing factor 1 antagonists selectively reduce ethanol self - administration in ethanol - dependent rats.