Sentences with phrase «relevant gene targets»

Not exact matches

Targeted gene therapies, however, had to wait for (1) the identification of the genes to target, (2) the cloning and / or sequencing of the relevant genes and in some cases, the specific disease - causing variant, (3) a full understanding of the normal gene function and regulation, and (4) the development of efficient ways to deliver genes to the relevant tissues at therapeutic levels.

Dluzen et al. demonstrate that differential expression of a set of miRNAs correlate with expression of a larger set of target genes in pathways which are relevant to disease pathogenesis and are differentially expressed between patients of different genetic background.

Thus, neural derivatives of disease - specific human pluripotent stem cells constitute a relevant biological resource for exploring the impact of adult - onset HD mutations of the HTT gene on the division of neural progenitors, with potential applications in HD drug discovery targeting HTT - dynein - p150Glued complex interactions.

Scholar - in - Training Awards in the amount of $ 1,000 for her submitted abstract entitled, «Activator protein 2 alpha (AP2α)- targeted methylation and silencing of relevant genes in head and neck squamous cell carcinoma (HNSCC) pathogenesis» to be presented at platform session at the 100th Annual Meeting of the American Association for Cancer Research, Denver, CO..

Targets of selection in the Thoroughbred genome contain exercise - relevant gene SNPs associated with elite racecourse performance

The approach to target validation utilizes RNAi, CRISPR, and ORF expression platforms to genetically perturb candidate target gene expression in relevant cancer cell lines, and then profile the resulting phenotypic changes with regard to their effect on various biochemical pathways.

Resolve the genomic diversity in a variety of tumors by targeting hotspots across 50 oncogenes and tumor suppressor genes relevant in a range of different solid tumors with SNV and indel mutation detection.

Also relevant are studies of the upstream mechanisms that regulate levels and function of those gene products, for example: how a transcription factor regulates multiple targets or how factors can regulate translation or post-translational modification of multiple proteins.

Linking non-coding genetic variants associated with the risk of diseases or disease - relevant traits to target genes is a crucial step to realize GWAS potential in the introduction of precision medicine.

Thus, nearly half of the first neighbours of differentially expressed proteins are already been known or suspected to be associated with colon cancer, while the other half (44 proteins) could be considered as novel genes potentially relevant for anticancer drug target discovery.