Sentences with phrase «relevant models for human disease»

«Of mice and men — are mice relevant models for human disease?»

Not exact matches

In 2009, he established the Center for Human Disease Modeling at Duke University, which aims to facilitate collaboration across disciplines and to develop physiologically relevant, scalable tools to study variation among human patient genHuman Disease Modeling at Duke University, which aims to facilitate collaboration across disciplines and to develop physiologically relevant, scalable tools to study variation among human patient genhuman patient genomes.

«New therapies for ALS are urgently needed — and our creation of human models using iPS cell technology will hopefully deepen our understanding of how the disease develops — and lead to relevant therapies for patients,» said Senior Investigator Steve Finkbeiner, MD, PhD, who leads ALS research at Gladstone.

To build upon the encouraging early discoveries, Helmsley renewed and expanded its Crohn's funding for the Institute in 2013 to begin new work with three major aims: 1) continue studies of individual genes to determine how genetic differences between Crohn's patients and healthy individuals contribute to the disease; 2) evaluate promising small molecules in disease - relevant studies and prioritize insights from genetics to help develop novel therapeutics; and 3) begin basic experimentation in animal models with Crohn's disease to provide the data necessary to begin testing new therapies in humans.

Here we tested whether human NSCs could be reprogrammed into iPS cells utilizing a similar strategy as described above since they represent a more clinically relevant source of cells for basic studies and modeling human disease.

«Using an animal model that's relevant to human disease, Fouchier and Kawaoka have shown that relatively few mutations may be required for an influenza virus to evolve into astrain that can pass effectively between individuals and cause serious illness.

Recently, mouse neural stem cells (NSCs) have been shown capable of reprogramming into a pluripotent state by forced expression of Oct3 / 4 and Klf4; however it has been unknown whether this same strategy could apply to human NSCs, which would result in more relevant pluripotent stem cells for modeling human disease.