Sentences with phrase «relevant mutations»

Target SNVs and indels across 47 driver genes with relevant mutations designed to cover a comprehensive set of myeloid disorders including acute myeloid leukemia (AML), myeloid dysplastic syndrome (MDS), myeloproliferative neoplasms (MPN), chronic myeloid leukemia (CML), chronic myelomonocytic leukemia (CMML), and juvenile myelomonocytic leukemia (JMML).

Using this approach, researchers can easily generate diseaserelevant isogenic models to determine the impact of correcting or introducing disease - relevant mutations on cellular phenotypes in a tissue - appropriate context.

But «we didn't find any [relevant mutations] at all» in the Yellowstone wolves, Barsh recalls.

«Highly sensitive genomic surveillance via cell - free DNA NGS reveals clinically relevant mutations»

To identify the accumulated mutations that restored viral fitness, the researchers sequenced the viral RNA using a supersensitive method called PrimerID sequencing, which enables tracking of all individual viral genomes so that any relevant mutations can be spotted.

To identify the relevant mutations the scientists analyzed the blood samples of 1,858 men from three independent cohorts in Europe and North America: the Swiss arm of the European Randomized Study for Prostate Cancer Screening, the large American Screening trial, Prostate, Lung, Colorectal, and Ovarian (PLCO), Princess Margaret Cancer Centre (University Health Network) and Mount Sinai Hospital (Sinai Health System) in Toronto.

And to study many developmental disorders, such as fragile X syndrome, researchers would be well served to be able to study a stem cell line that contained the relevant mutations.

At the site of the relevant mutation, the IQ difference depends on a change of a single DNA «letter» from C, standing for cytosine, to T, standing for thymine.

Created from engineered cell lines, cfDNA Reference Standards are available in both singleplex and multiplex format with cancer - relevant mutations.

Animals with the relevant mutation show symptoms of advanced neurodegeneration and a restricted ability to move.

«This is an attempt to generate an unbiased view of what genes are expressed in every cell type in the developing human brain in order to highlight potential cellular vulnerabilities in patient - relevant mutations,» said Nowakowski.

This model is particularly amenable to gene editing technology, which makes it possible to design cells with specific disease - relevant mutations — a boon for those studying the cause and progression of metabolic diseases of the liver.

Dr. Malaspina said that the findings of her study «suggest that relevant mutations are there» in such sporadic cases «as well as in familial cases.»

The relevant mutations in Amrose can be characterized via its evolutionary tree.