Sentences with phrase «relevant tissues»
Since different species of animals may clear infections in different ways, they wanted to make sure the virus was getting to the most relevant tissues of the pregnant mice.
sciencedaily.com
Genetic data combined with information on gene expression and epigenomics in relevant tissues, and clinical information, can provide clues about the effects of genetic changes within an individual's genome that increase or decrease one's risk of developing type 2 diabetes and its complications, including heart and kidney disease.
She collects DNA (blood draw) or relevant tissue samples at surgical biopsy time or at definitive surgical correction, and processes the sample (prepares for RNA extraction, flash freeze or cell culture).
«For example, reprogrammed cells in a patient could make targeted, therapeutic decisions in the most relevant tissues, obviating the need for complex diagnostics and broad spectrum approaches to treatment.»
«These are very cool compounds, but lipids aren't typically used as drugs for several reasons, including that they might not be able to reach effective doses in the relevant tissues,» he says.
Targeted gene therapies, however, had to wait for (1) the identification of the genes to target, (2) the cloning and / or sequencing of the relevant genes and in some cases, the specific disease - causing variant, (3) a full understanding of the normal gene function and regulation, and (4) the development of efficient ways to deliver genes to the relevant tissues at therapeutic levels.
To impute aging phenotypes directly to p16Ink4a - expressing senescent cells, van Deursen and colleagues with expertise in the aging and senescence of the relevant tissues developed and tested the effects of a pharmacologically - inducible system for the ablation of p16Ink4a - expressing cells.
The SMN2 splicing modifiers described in the Science article penetrated into all mouse tissues tested, including brain, spinal cord and muscle, and thus improved SMN2 RNA splicing to increase SMN protein production in these disease - relevant tissues.