Since Ras - driven cancers often rely on autophagy for growth and survival, this raised the question: Is proteome
remodeling by autophagy important, and if so, by what mechanism?
«This
remodeling process of the cell proteome
by autophagy is an important immune - suppressive survival mechanism for Ras - driven cancers, and inhibiting
autophagy can provide a means to target these aggressive cancers,» notes White, who is also a distinguished professor of molecular biology and biochemistry at Rutgers School of Arts and Sciences.