Surveillance
Renal Allograft Biopsy on Diagnosis of BK Virus Nephropathy in Chinese Renal Transplant Recipients
Freedman, B. I., et al. «Apolipoprotein L1 gene variants in deceased organ donors are associated with
renal allograft failure.»
Analysis of the sample can determine if a kidney donor (potential live kidney donor or deceased kidney donor) or a patient inherited two APOL1 gene renal - risk variants that contribute to poorer
renal allograft survival after transplantation.
We have also generated T - regs (CD4 + / 25high / 127low / --RRB- in vitro from donor AD - MSC and recipient peripheral blood mononuclear cells and these T - regs are infused in thymus of
renal allograft recipients after kidney transplantation.
Correlation of leukocyte groups with skin and
renal allograft survival indicates that ranks of histocompatibility based upon current genetic concepts of the HL - A system may provide an approach to the selection of optimally compatible subjects for clinical organ transplantation.
Current projects are investigating: 1) the expression of inflammatory genes during ischemia and reperfusion of kidneys during urology transplantation and in mouse models; 2) the expression of inflammatory genes and proteins in urine as markers indicating the presence of rejection in
renal allografts; and 3) the role of adhesion molecules and chemokines in directing leukocyte infiltration into organ allografts.
Not exact matches
Upon receiving deceased donor kidneys from African Americans with two APOL1
renal - risk variants, transplant recipients experience earlier
allograft failure.
For example, if it is determined that a donor kidney is at greater risk for shortened
allograft survival based on presence of two APOL1
renal - risk variants, rapid re-assessment of allocation of the kidney may be advisable.
APOL1 genetic testing can help you make informed decisions about how to manage future risks of
allograft failure in your
renal transplant patients.