A Phase III, Multicenter, Randomized, Placebo - Controlled, Double - Blind Study Of Atezolizumab (Anti − PD - L1 Antibody) As Adjuvant Therapy In Patients
With Renal Cell Carcinoma At High Risk Of Developing Metastasis Following Nephrectomy
Project Title: Identification of molecular alterations associated with the progression of clear
cell renal cell carcinoma by mass spectrometric approaches
Javidnia says analysis in this study shows pazopanib penetrates the mice's blood - brain barrier when given the equivalent of half of dose given
for renal cell carcinoma treatment.
Tang and his colleagues in the laboratory of Dr. David Hsu at the Duke Cancer Institute implanted
renal cell carcinoma tumors into mice and then treated the animals with sulfasalazine, a drug that blocks cystine uptake.
«
Most renal cell carcinomas learn to escape therapy after a couple of years,» said Robert Weiss, professor of medicine at UC Davis, chief of nephrology at Sacramento VA Medical Center, and head of the kidney cancer working group at the UC Davis Comprehensive Cancer Center.
An FDA approved drug to
treat renal cell carcinoma appears to reduce levels of a toxic brain protein linked to dementia in Alzheimer's and Parkinson's diseases when given to animals.
They discovered that overactivation of this pathway, which is observed in some types of cancer such
as renal cell carcinoma, melanoma and pancreatic cancer, is important to promote and support the growth of cancer cells in culture and animal models.
«
Because renal cell carcinoma most often presents as incidental, small, localized, and often indolent tumors in elderly patients with high rates of CKD and comorbidities, competing nononcologic mortality risks should be carefully considered when counseling patients.»
Researchers at UC Davis have shown that docosahexaenoic acid (DHA), a fatty acid commonly found in fish and fish oil supplements,
reduces renal cell carcinoma invasiveness, growth rate, and blood vessel growth when combined with the anti-cancer therapy regorafenib.
About three - fourths of
renal cell carcinoma cases are marked by a missing VHL tumor - suppressor gene, which keeps healthy cells from developing into tumors.
Diets high in meat may lead to an increased risk of
developing renal cell carcinoma (RCC) through intake of carcinogenic compounds created by certain cooking techniques, such as barbecuing and pan-frying.
In an effort to further exploit the potential of Pexa - Vec to activate the immune system to fight cancer, as seen in McDonald's preclinical data, SillaJen recently announced a new clinical trial in collaboration with New York - based Regeneron Inc. to test Pexa - Vec and REGN2810, a PD - 1 checkpoint inhibitor, in combination
against renal cell carcinoma, and recently signed a sponsored research agreement with UCSF to enable joint support of parallel preclinical experiments by McDonald's team.
First - line combination therapy with the programmed death ligand 1 (PD - L1) inhibitor avelumab and the vascular endothelial growth factor receptor tyrosine kinase inhibitor axitinib resulted in encouraging antitumor activity in patients with previously
untreated renal cell carcinoma (RCC) and had a manageable toxicity profile, according to the results of the JAVELIN Renal 100 study published in Lancet Oncology.
Contrasting properties of hypoxia - inducible factor 1 (HIF - 1) and HIF - 2 in von Hippel - Lindau - associated renal cell carcinoma
About Blog The KCCure blog covers kidney cancer research news and stories
about renal cell carcinoma clinical trials and treatments to cure kidney cancer.
What's more, one patient who had failed multiple prior treatments
for renal cell carcinoma had a confirmed durable partial response and two patients with colorectal cancer had prolonged stable disease.
Axitinib, a drug used to
treat renal cell carcinoma, has been shown to be effective at inhibiting the Abl kinase activity in patients with BCR - ABL1 (T315I).
Researchers studied food questionnaires for 335 people
with renal cell carcinoma, the most common form of kidney cancer, and 337 healthy controls.
The results are explained in «Antioxidant micronutrients and the risk
of renal cell carcinoma in the Women's Health Initiative cohort,» featured in the Feb. 15 issue of Cancer.
Mr. Kaisary's main interest is the diagnosis and management of prostate cancer and benign prostate disease together with bladder cancer and
renal cell carcinoma.
Renal cell carcinoma, also known by the eponym Grawitz tumor, is the most common form of kidney cancer arising from the renal tubule.
Spontaneous remission is more likely with certain kinds of cancer, such as melanoma and
renal cell carcinoma.
In the last few years, much progress has been made in this field of cancer research, also for the treatment of
renal cell carcinomas.
Despite decades of effort, however, researchers were unable to develop a mouse model of
renal cell carcinoma — until now.
A gene known to control brain growth and development is heavily involved in promoting clear cell
renal cell carcinoma, the most common form of kidney cancer, researchers from Mayo Clinic in Florida are reporting.
The Ogretmen laboratory screened previously reported microarray data sets of several human tumor tissues (metastatic head and neck squamous cell carcinoma, melanoma, and
renal cell carcinoma) and showed that, in these samples, only the levels of CerS4 were significantly decreased.
However, death rates due to
renal cell carcinoma (kidney cancer) have not decreased, indicating that surgery may be of little or no benefit to some patients.