Not exact matches
Drawing on Toronto's leading stem
cell and
tissue engineering expertise, one group will focus on new models for
repairing damaged hearts.
A seriously ill person in need of embryonic stem
cells to
repair damaged
tissue.
The antioxidants in AppleActiv play an important role in neutralizing oxidative damage caused by free radicals,
repairing damage and protecting the normal functioning of
cells and
tissues.
These amino acids can be used to build or
repair muscle fiber, to create any number of
cells, to concoct hormones or to build any number of
tissues that the body might need.
Phosphorus is also used by the body to synthesize protein for
cell and
tissue growth and
repair.
Despite a tremendous amount of scientific study, many outstanding mysteries still surround the way in which
cells in living
tissue respond to and
repair physical damage.
A FATTY apron of
tissue called the omentum, which sits over the stomach and intestines, may be the perfect spot to grow patches of
cells for heart
repair.
«It was particularly exciting to observe that the
repair of the skin epidermis involves the activation of very different stem
cells that react the same way to the emergency situation of the wound and have the power to completely restore the damaged
tissue», comments Mariaceleste Aragona, the first author of the study.
Researchers from the Institute for Integrated
Cell - Material Sciences (iCeMS) of Kyoto University and the Department of Cardiovascular Surgery of Osaka University have developed effective and convenient Cardiac
Tissue - Like Constructs (CTLCs) for
repairing myocardial infarctions.
Stem
cells have the potential to
repair most
tissues in the body.
One of the key questions in biology is to identify how
tissues are
repaired after trauma and understand how stem
cells migrate, proliferate, and differentiate to
repair tissue damage.
The secret to
repairing our
tissues and growing new organs is getting all touchy - feely with
cells
Previous researchers have also used
cell transplant technologies to
repair injured hearts, but these used CMs organized in two dimensions with a random, myofibril structure, which is different from natural heart
tissue.
When the modified
cells were injected into mice whose hind limbs had been injured, the
tissue that regrew to
repair the damage had three times the blood vessel density of similar
tissue in mice given unmodified
cells.
The pairing of the two delivered the breakthrough solution, the researchers said, as neurons responded to the molecule, regenerating synapses in mouse ear
tissue that led to
repair of the hair
cells and neurons, which are essential to hearing.
Defined as the harnessing of living processes to achieve healing and
repair of damaged and diseased
tissues by Tim Hardingham, director of the UK Centre for
Tissue Engineering, it is a field that requires collaborative research involving
cell and molecular biologists, chemical engineers, materials scientists, and surgeons.
Furthermore, the same team is applying new microgravity technology — originally developed by NASA for the International Space Station — to make large enough quantities of the stem
cells to
repair tissue damage in patients.
But the neurosurgeon who fused Boesen's neck bones to stabilize his spine offered a ray of hope: Boesen might qualify for an experimental treatment that uses stem
cells to
repair damaged
tissue.
Hartgerink is a pioneer in the development of self - assembling multidomain peptide (MDP) hydrogels, which mimic the body's extracellular matrix to encourage the growth of
cells and vascular systems for
tissue repair.
The stem -
cell - derived bone
tissue helped
repair cranial bone defects in mice without developing tumors or causing infection.
Investigators at Johns Hopkins report they have developed human induced - pluripotent stem
cells (iPSCs) capable of
repairing damaged retinal vascular
tissue in mice.
«The time is coming when we'll
repair heart
tissue after a heart attack and restore blood flow to limbs that would otherwise be amputated,» says stem
cell researcher Robert Lanza of Advanced Cell Technology in Massachuse
cell researcher Robert Lanza of Advanced
Cell Technology in Massachuse
Cell Technology in Massachusetts.
The enzyme, called tankyrase, may prove useful for extending the lives of cultured
cells grown to
repair burned skin and other damaged
tissue.
Once stem
cells can be grown and differentiated in a controlled way to replace degenerated
cells and
repair tissues, medical science may then be able to diagnose and cure many intractable diseases at their earliest stages, such as type 1 diabetes, Parkinson's disease, various cardiovascular diseases, liver disease, and cancer.
Originally, researchers thought Th2 response had evolved to promote
tissue repair; however, in the context of lung virus infections, Th2
cells appear to contribute to the overactive immune responses that endanger patients.
Labs could rejuvenate
cells from patients and perhaps then grow them into new
tissue that could
repair parts worn out by old age or disease.
Now, with new kinds of technologies that are coming up, new types of
tissue engineering and, you know, some of the hopes that people have for stem
cells and [the] like, it may be interesting to see if there are other ways, alternatives to dealing with really badly damaged hearts that would involve growing a new heart or replacing or
repairing the damage d to a badly damaged heart that might make artificial hearts less important in the somewhat more distant future.
As fluid and white blood
cells rush to the damaged
tissue, it becomes inflamed in an effort to
repair the
tissue and protect it from further damage.
As the wound heals, the gel breaks down into amino acids — the building blocks of proteins — that can be taken up by nearby
cells and used for
tissue repair, according to MIT neuroscientist Rutledge Ellis - Behnke.
However, ChABC gene therapy decreased the presence of these
cells and increased the presence of other immune
cells called M2 macrophages that help to reduce inflammation and enhance
tissue repair.
Nevertheless, as people grow older the number of stem
cells decreases and those that remain are less able to grow and
repair tissue.
The scientists, led by Dr Paul Genever in the Arthritis Research UK
Tissue Engineering Centre in the University's Department of Biology, have developed a technique to rejuvenate
cells from older people with osteoarthritis to
repair worn or damaged cartilage thus reducing pain.
A study published by
Cell Press November 7th in the journal
Cell has revealed that an evolutionarily conserved gene called Lin28a, which is very active in embryos but not in adults, enhances
tissue repair after injury when reactivated in adult mice.
Some data suggest that the mechanisms for each CHI3L1 function -
cell protection and
tissue repair - involve different pathways and or receptors.
Blood stem
cells can occasionally become muscle
cells and help
repair damaged
tissue, new research finds.
In a study published online in Circulation Research late last year, Chaudhry and colleagues found that fetal
cells in mice migrated to the mother's heart, differentiated into functioning cardiac
cells, and accelerated
repair to damaged heart
tissue.
The lingering of the fetal DNA, research suggests, may be a mixed blessing for a mom: The
cells may benefit the mother's health — by promoting
tissue repair and improving the immune system — but may also cause adverse effects, such as autoimmune reactions.
Importantly, the micro environment created by the features of a breast implant is critical for breast
tissue cells to adhere to that surface and grow on,» said Dr Ardeshir Bayat, from the University's Institute of Inflammation and
Repair, who led the study.
It feeds back to protect injured
cells from dying and simultaneously stimulates
tissue repair to patch the damage that has occurred.
All of these findings were supplemented with several other experiments that were designed to learn how CHI3L1 interacts with other
cells involved in the
tissue repair response in both human and mouse lungs.
Their series of experiments showed that a single application of concentrated, mature B
cells accelerated wound healing and improved the quality of
tissue repair in both animal models.
But even more far - ranging treatments may be possible with embryonic stem
cells, the blank - slate
cells that give rise to all organs and
tissue types and that (theoretically) can
repair all forms of organic damage and disease.
The substance may be used for biomedical applications, ranging from
cell culture and drug delivery to
repairing and replacing
tissue, organs and cartilage.
Recent experiments, for instance, suggest that when an organ lacks LGR -5-positive
cells, differentiated
cells may be able to «dedifferentiate» and
repair tissues — a radical change from the one - way street toward specific identities that stem
cells were thought to travel.
Twenty - five years from now, our kids will only know some diseases, such as osteoporosis, from old books, and by then we will probably know how to
repair tissues with stem
cells.
The study of these creatures has the potential to be rather robust in implications for regenerative medicine, an area of treatment for
repairing or replacing human
cells,
tissues or organs on Earth to restore normal function.
Stem
cell treatments are already a reality for diseases of the blood, such as leukemia and sickle -
cell anemia (like Paizley's), and for
tissue repair of the skin and the cornea.
Burdick's team and other research groups are also designing hydrogels that contain drugs or
cells that can
repair heart
tissue.
Understanding stem
cell biology may mean we can control stem
cell behaviour and harness their power for
tissue repair.
Dr. Stoddart's main research focus is using autologous stem
cells and gene transfer to
repair musculoskeletal
tissues using a
cell therapy approach.