Sentences with phrase «repair machinery of the cell»

The present study employed computer simulations to screen 300,000 fragments using an atomic resolution structure of the cancer target MTH1, an enzyme part of the DNA - repair machinery of the cell.

Not exact matches

One big one: «Not everybody appreciates the way CRISPR technology works — it makes the cut in the DNA but it doesn't take care of the repair — so we rely on the cells» fundamental machinery to do that,» Doudna says.

To explore the role of DNA repair in translocation formation, the researchers inhibited key components of the DNA damage response machinery within cells and monitored the effects on the repair of DNA breaks and translocation formation.

They also gave the cells a correct copy of the A1At gene so that the cell's DNA repair machinery would use it as a template to heal the break.

One group of drugs — primarily targeting machinery involved in the cell cycle, protein chaperoning or DNA repair — elicited similar patterns of response across all cell lines.

In the Medalist + C group, there were alterations in the DNA damage checkpoint pathway machinery that monitors the DNA repair process of the body's cells.

In REPAIR, the deactivated Cas13b enzyme seeks out a target sequence of RNA, and the ADAR2 element performs the base conversion without cutting the transcript or relying on any of the cell's native machinery.

This RNA binding protein, upregulated upon B cell activation, post-transcriptionally regulates components of the DNA damage repair machinery, such as p53, silencing the mRNA and keeping the transcripts captive in RNA stress granules.

Many mechanisms of MDR have been described, such as the overexpression of MDR1 (also known as P - glycoprotein or ABCB1) or other ATP - dependent transporters that pump drugs out of the cancer cells, amplification of drug - inactivating enzymes, mutations or modifications of drug targets, alterations in DNA repair machinery, and increased resistance to apoptosis (1 — 3).

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