If the deep microbes spend as much on maintenance as surface microbes do, he says -
repairing radiation damage to their DNA, keeping their membranes intact — they should have nothing left for the microbial prime directive: divide and multiply.
Not exact matches
This changes a lot of what scientists thought they knew about how water bears deal with
radiation, as they were previously thought to have proteins that
repaired damaged DNA, rather than proteins that halt
damage altogether.
Laboratory experiments on animals indicate that as doses decrease, less and less
damage escapes DNA -
repair mechanisms, says Yoshihisa Matsumoto, a
radiation biologist at the Tokyo Institute of Technology.
PARP inhibitors prevent cancer cells from
repairing themselves after experiencing DNA
damage (for example from chemotherapy or
radiation).
Our body has a system to
repair DNA
damage (DNA
repair mechanism), so why a normal cell turns into a cancer cell and why
radiation exposure causes cancer have not been clarified.
A group of researchers at Osaka University found that if DNA
damage response (DDR) does not work when DNA is
damaged by
radiation, proteins which should be removed remain instead, and a loss of genetic information can be incited, which, when
repaired incorrectly, will lead to the tumor formation.
Mutations occur, for example, when cells copy their DNA incorrectly or fail to
repair damage from chemicals or
radiation.
Surprisingly, low - dose
radiation takes longer for the body to
repair than
damage from high doses does.
The altered microbes bred easily, even in a radioactive chamber, by rapidly
repairing DNA
damaged by
radiation.
Although its raison d'être remains elusive, the gene appears to play an important role in DNA
repair: Mice lacking the protein Brca1 have trouble fixing DNA
damage induced by
radiation, for instance, and the protein clumps in the nucleus at sites where DNA is broken.
The
radiation damage in the DNA may have been
repaired when the sperm cells were combined with the eggs, says Andrew Wyrobek at Lawrence Berkeley National Laboratory in California.
They showed that basal cells were much more efficient at
repairing DNA
damage, allowing them to survive and reproduce following exposure to chemicals or
radiation that
damaged the DNA.
Experiments with mouse embryo support cells that express mutant DUB or pseudo-DUB proteins show an impaired immune response when infected with a virus and impaired DNA
damage repair when exposed to ionizing
radiation, further validating the need for complex's correct structure.
Biologists have generally assumed that the
damage will be proportional to the dose, but in vitro studies have shown that cells can
repair modest DNA
damage caused by
radiation — and that low - dose
radiation might even protect the cell against future exposure.
So while it's true that organisms living deep in the Earth are not exposed to the high - energy
radiation found when you travel between planets or more hypothetically between stars, the systems that cells have evolved to
repair damage done by reactive oxygen species will be useful whether they arise from rocks or from cosmic rays.
The
damage that it will
repair is the one that is causal in senenscence of DNA pathway (such x-ray
radiation causing senescence) and oncogenic activated senescence; but not of the type of replicative senescence (that's the domain of telomeres / telomerase / sub-telomeres and epigenetics) and cellular replication / proliferation.
I have a career - long interest in understanding the
repair of DNA double - strand breaks, the most
damaging lesion induced by
radiation.
GSC resistance to
radiation due to upregulation of pro-survival signaling and enhanced DNA
damage repair capacity.
Such diseases are believed to be initiated by mutations and rearrangements of the DNA sequence.DNA
damage generated by ionising
radiation, simple alkylating agents or endogenously hydrolytic and oxidative processes is corrected by the base excision
repair (BER) pathway.
It also has incredible benefits in healing and
repairing damaged skin, including wound healing, and because it is also an antioxidant, it protects against UV
radiation.
Since B12 helps
repair DNA that is
damaged by
radiation or oxidation, it plays a role in protection against cancer.
Unique «Mitochondrial Antioxidant» Fights Premature Aging By Jim English Alpha - lipoic acid (ALA) is a unique, vitamin - like antioxidant that can combat
radiation sickness,
repair damaged livers, treat diabetes and diabetes - related conditions (polyneuropathy) and protect against oxidative processes that promote premature aging and degenerative diseas >> Read Article