Their work arose out of a discovery in the late 1980s of neighboring bacterial DNA segments consisting of
repeating nucleotide sequences, which flank short segments.
Rice University scientists have uncovered new details about how
a repeating nucleotide sequence in the gene for a mutant protein may trigger Huntington's and other neurological diseases.
Family Tree DNA's Y chromosome test ($ 119, familytreedna.com) looks for SNPs and small stretches of
repeating nucleotides on the Y chromosome that fathers pass on to their sons.
Scientists at King's College London have found that people who have previously suffered from acne are likely to have longer telomeres (the protective
repeated nucleotides found at the end of chromosomes) in their white blood cells, meaning their cells could be better protected against aging.
Another possibility, Traynor says, is that
the repeated nucleotides cause a toxic buildup of messenger RNA, a key player in the cellular machinery for reading out DNA to make protein.
Not exact matches
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder that has been linked to toxic aggregates of poly - Gly - Ala (poly - GA) peptides generated by aberrant translation of an expanded
nucleotide repeat sequence.
The lab has also shifted from testing genetic markers known as short tandem
repeats (STRs), which are standard in paternity testing, to recording single letter variants in the genetic code known as single
nucleotide polymorphisms, or SNPs, which are rarely used for this purpose.
This mutation probably happened because the sequence of three
nucleotides was
repeated, and this
repeat just happened to be in the right place in waterhemp's genetic code.
In myotonic dystrophy and other related neurological disorders, the symptoms stem from
repeated individual
nucleotides, or «building blocks,» in the RNA in muscle tissue cells that can build up over time.
The researchers also found that many endogenous genes had additional
repeating sections of A and T
nucleotides that mark them as «self» and not foreign.
Gregory Koblentz, deputy director of the biodefense program at George Mason University in Fairfax, Virginia, speculates that the FBI may have used a recent technique based on the identification of Single -
Nucleotide Repeat markers in the anthrax genome that allows for differentiating between variants of the same strain.
Both teams found that a
repeated string of six
nucleotides — the building blocks of DNA that make up the «letters» of the genetic code — in this gene can cause ALS or FTD.
According to Rothstein, researchers knew that the C9orf72 mutation, rather than changing one building block of DNA to another, caused a stretch of six DNA
nucleotides to
repeat hundreds of times.
MNLPs join the list of sequence variations that have been discovered in recent years, including SNPs (single
nucleotide polymorphisms), INDELs (insertions or deletions of various lengths), and STRs (short tandem
repeats).
FRT sites and loxP sites differ at the
nucleotide level but share an overall structure of 13 base pair palindromic
repeats separated by an 8 bp asymmetric core.
In a normal, working copy of the gene, there is a section containing a pattern of three DNA
nucleotides — guanine, adenine, adenine (GAA)--
repeated up to about 20 times.
Abbreviations: ASC, apoptosis - associated speck - like protein containing a caspase - recruitment domain; ATM, adipose - tissue - resident macrophage; BAT, brown adipose tissue; CCR2, CC chemokine receptor 2; CHOP, C / EBP (CCAAT / enhancer - binding protein)- homologous protein; DHA, docosahexaenoic acid; EPA, eicosapentaenoic acid; ER, endoplasmic reticulum; GPCR, G - protein - coupled receptor; HIF, hypoxia - inducible factor; IFNγ, interferon γ; IKK, inhibitor of nuclear factor κB kinase; IL, interleukin; IRS - 1, insulin receptor substrate - 1; JNK, c - Jun N - terminal kinase; LDL, low - density lipoprotein; Ldlr, LDL receptor; LXR, liver X receptor; MCP - 1, monocyte chemoattractant protein 1; miRNA, microRNA; mTOR, mammalian target of rapamycin; NAFLD, non-alcoholic fatty liver disease; NF - κB, nuclear factor κB; NLRP3, NLR (
nucleotide - binding - domain - and leucine - rich -
repeat - containing) family, pyrin - domain - containing 3; oxLDL, oxidized LDL; PKR, double - stranded RNA - dependent protein kinase; PPAR, peroxisome - proliferator - activated receptor; STAT6, signal transducer and activator of transcription 6; SVF, stromal vascular fraction; TLR, Toll - like receptor; TNFα, tumour necrosis factor α; UPR, unfolded protein response; WAT, white adipose tissue
The scientists concluded that version of the FMR1 sequence with over 200
nucleotide repeats can result in the syndrome's production.
A normal version of the FMR1 gene sequence, where the fragile X syndrome can develop, contains 5 - 55
nucleotide (CGG)
repeats.
The paucity of single
nucleotide diversity among breeds is consistent with other studies (29 — 32) and stands in stark contrast to the abundance of coding
repeat variation we found in these same genes known to be involved in the developmental processes under selection in the radiation in dog breed morphologies.
DNA is a long polymer made from
repeating units called
nucleotides.
Action by victim of
repeat violence, sexual violence, or dating violence for protective injunction; dating violence investigations, notice to DNA is a long polymer made from
repeating units called
nucleotides.