Their work arose out of a discovery in the late 1980s of neighboring bacterial DNA segments consisting of
repeating nucleotide sequences, which flank short segments.
Rice University scientists have uncovered new details about how
a repeating nucleotide sequence in the gene for a mutant protein may trigger Huntington's and other neurological diseases.
Not exact matches
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder that has been linked to toxic aggregates of poly - Gly - Ala (poly - GA) peptides generated by aberrant translation of an expanded
nucleotide repeat sequence.
This mutation probably happened because the
sequence of three
nucleotides was
repeated, and this
repeat just happened to be in the right place in waterhemp's genetic code.
MNLPs join the list of
sequence variations that have been discovered in recent years, including SNPs (single
nucleotide polymorphisms), INDELs (insertions or deletions of various lengths), and STRs (short tandem
repeats).
The scientists concluded that version of the FMR1
sequence with over 200
nucleotide repeats can result in the syndrome's production.
A normal version of the FMR1 gene
sequence, where the fragile X syndrome can develop, contains 5 - 55
nucleotide (CGG)
repeats.