iPSCs directed to differentiate into specific cell types offer the possibility of a renewable source of
replacement cells and tissues to treat ailments, including Parkinson's disease, spinal cord injury, heart disease, diabetes, and arthritis.
Not exact matches
ReInnervate, a start - up in Durham, England, is developing a tiny, three - dimensional plastic scaffolding on which human
cells can be grown into artificial
tissue,
and perhaps eventually into
replacements for organs.
He earned degrees in
cell biology
and tissue engineering
and eventually got a job in a lab run by Vladimir Mironov, who was investigating the use of bioprinting — 3 - D printing using living
cells — to generate
replacement organs.
As well as allowing the use of stem
cells grown from established
cell lines, the technology could enable the creation of improved human
tissue models for drug testing
and potentially even purpose - built
replacement organs.
Da Cruz
and his team grew
replacement RPE
cells from human embryonic stem
cells on a thin plastic scaffold, before transplanting the
tissue into the back of each volunteer's eye.
And our normal
tissues would be preserved intact, provided that we underwent regular rounds of
replacement of stem
cells.
But for
cell replacement therapy to realize its potential, I anticipate that scientists must solve the developmental code, the set of rules that govern the formation of
tissues, organs,
and beings from the original single
cell — the zygote.
There is evidence that chronic disabilities such as spinal cord lesions, diabetes,
and Parkinson?s disease, where
replacement of just one
cell type restores
tissue function, can be treated with differentiated embryonic stem
cells.
Most of the BMBF's support for stem
cell research is channelled through two priority programmes: «Biological
Replacement of Organ Functions»
and «
Tissue Engineering».
The result — the second such finding in the past year — suggests that similar
cells from human testicles might have similar powers, paving the way to creating
replacement tissue for men who have suffered damage from heart attacks or other injuries
and avoiding some of the controversy surrounding embryonic stem
cells (ESC).
The new approach builds on information gleaned from developmental studies of embryonic stem
cells (see story # 16)
and one day may be used to create healthy
replacements for harmed or diseased
tissue.
Japanese stem
cell biologist Hiromitsu Nakauchi is pioneering a technique that ultimately aims to implant human pluripotent
cells into pig embryos to create
replacement human
tissues and organs.
Those two papers were groundbreaking because they put forward a method for generating stem
cells far simpler than any previously reported, a development that could advance regenerative medicine, in which scientists try to grow
replacement tissues as a treatment for diseases
and injuries.
Researchers at Whitehead Institute have uncovered a framework for regeneration that may explain
and predict how stem
cells in adult, regenerating
tissue determine where to form
replacement structures.
The new stem
cell, developed at the Salk Institute, holds promise for one day growing
replacement functional
cells and tissues.
The new stem
cell (green), developed at the Salk Institute, holds promise for one day growing
replacement functional
cells and tissues.
The authors note that the formation of each different organ bud type may require some fine tuning to optimize
tissue self - organization,
and further addition of neural
cell types may be necessary, but this research may soon provide exciting model systems for the study of basic biology
and pathology as well as providing appropriate
replacement tissues for the treatment of many patients with no other viable options.
I am excited by the ability of regenerative medicine to provide
replacement tissue made from a patient's own
cells and what it can mean to the patient's recovery
and long - term health.
In the long run, scientists hope to use organoids
and induced pluripotent stem
cells to engineer
tissue replacements in patients suffering from diseases that currently are treated with direct transplants of fetal
tissue.
We could have
replacement tissues and organs that perfectly match the recipient because they were cloned from their own
cells.
The WFIRM research team is working to engineer
replacement tissues and organs
and develop healing
cell therapies for more than 30 different areas of the body.
The Society believes that research involving the transfer of a human nucleus into an animal egg will lead to important new knowledge about
cell nuclear
replacement (CNR) technology
and, if it were to prove possible to produce embryonic stem
cells by this route, would increase understanding of how to programme these
cells to develop into different
tissue types.
Your own healing
cells can target a slowed degenerative progression of COPD, restore blood flow, address system - wide inflammation
and stimulate the repair
and replacement of damaged lung
tissue.
Diagnostics,
cell replacement and protection, drug discovery,
tissue engineering, non-invasive imaging,
and many other approaches to disease diagnosis
and clinical management are likely to be transformed by research in this area.
Human Growth Hormone is the «master hormone» controlling many organs
and body functions
and is directly responsible for stimulating
tissue repair,
cell replacement, brain functions,
and enzyme function!
In BHRT (Bioidentical Hormone
Replacement Therapy), natural progesterone is seen as a highly effective treatment as it can counteract the effects of estrogen, which naturally stimulates
cell growth in
tissues containing estrogen receptors
and contributes to symptoms of endometriosis.
Stem
cell therapy offers the possibility of using these stem
cells to grow into
replacements for injured or diseased
tissues such as bone, cartilage, muscle, nerves,
and so on.
Although veterinarians initially believed that the main use for stem
cells would be as
replacements for damaged
cells, it is now known that stem
cells produce anti-inflammatory substances
and other compounds involved in
tissue repair.
In CAH, continuous liver inflammation
and cell death eventually lead to the
replacement of the normal liver
tissue with scar
tissue.
Chronic hepatitis in dogs, also called inflammatory canine hepatic disease, refers to a syndrome in which death of hepatic
cells (hepatocellular necrosis) has occurred
and is associated with a chronic inflammatory process which typically progresses to liver fibrosis (
replacement of hepatic
tissue with fibrous
tissue)
and cirrhosis (progressive derangement of the liver architecture
and function).