The authors caution that further study and
replication of their results in different populations is needed to verify their model before it will be useful for individual genetic tests — or before longevity «cocktails» are created.
Materials and Methods: The materials and methods section should provide sufficient information to allow
replication of the results.
We'd need to see
replication of this result with larger numbers of patients before drawing conclusions.
Getting one stock / trade right for a unique reason has limited value because there is no ability for
replication of the results.
There is a larger environment (science generally), where
replication of results is a critical issue.
As is usual, it is abundantly obvious that none of the terriers clamoring here for release of all data and code have any idea what the concept of
replication of results actually means.
One specific issue which I don't think has been mentioned yet is
the replication of the result using completely different data and / or methods.
In that fashion science will quickly clean house and require papers to have data and method made available sufficient for independent
replication of the result by a HOSTILE examiner.
Nevertheless, the authors are to be congratulated on bringing the partial least squares method to the attention of a wide audience of climate scientists, for the thoroughness of their methods section and for making pre-processed data and computer code readily available, hence enabling straightforward
replication of their results and testing of alternative methodological choices.
As these findings are discussed, argued, examined from many angles, and made known through the usual scientific channels — laboratories around the world, science departments of universities, the National Academy of Sciences, the National Research Council, peer review,
replication of results, etc., etc. — there will be disagreements.
Pretty hard to support any conclusions reached if the data it is based on is not available, or is
replication of results no longer a valid part of the scientific method?
The review also found «The Review believes that all data, metadata and codes necessary to allow independent
replication of results should be provident concurrent with peer - reviewed publication.»
Replication of results is key to the scientific method.
However, few studies investigated these associations and
replication of results is needed.
Genetic association studies in the field of psychiatric and psychological genetics have been suffering from inconsistencies in
replications of results.
A replication of these results in larger samples would thus encourage the diffusion of this non-invasive technique in terms both of relational support and enhancement of parenting abilities.
Not exact matches
I thought about the ability we all have to actually rewire our brain's synapses so the real
results of repetition become an automatic and almost perfect
replication of a defined goal.
As the dust settled, this week's
results look like a minor - key
replication of what happened 12 months ago.
Inflammation in response to the Salmonella stressed the pathogens themselves, and the
resulting damage promoted bacteriophage
replication, followed by rupture
of the bacterial cell wall and release
of the bacteriophages.
That shift can lead to «an environment that is conducive to T - cell
replication that
results in amplification
of subsets
of viral populations and creation
of genetically distinct, compartmentalized viral populations,» they explained.
Despite this thoroughness, while 97
of the original studies reported significant
results, only 35
of the
replications reported the same.
Replication The Science Journals encourage the submission of replication studies that provide new insights into previously publish
Replication The Science Journals encourage the submission
of replication studies that provide new insights into previously publish
replication studies that provide new insights into previously published
results.
The existence
of these guidelines does not obviate the need for
replication or independent verification
of research
results, but should make it easier to perform such
replication.
The
results showed that cells in which NOD1 was activated had decreased levels
of CMV
replication compared to controls.
During meiosis, the genome
of a diploid germ cell, which is composed
of long segments
of DNA packaged into chromosomes, undergoes DNA
replication followed by two rounds
of division,
resulting in haploid cells called gametes.
The
results highlight the importance
of careful observation and controls, as well as the potential benefits
of replication studies.
The
results «pave the way for
replications to enter the new - normal way
of doing research,» says Uri Simonsohn, a psychologist at the University
of Pennsylvania.
«The principle that scientists should be willing to expose their ideas and
results to independent testing and
replication by others, which requires the open exchange
of data, procedures and materials, is vital.»
«
Replication of scientific
results is not very sexy, but it's crucial,» says Gage.
and the answer, according to the
results of this
replication study, is yes.
On the up side, despite the sobering
results, the effort seems to have drawn little
of the animosity that greeted a similar
replication effort last year.
«For us, these
results are very encouraging,» says Susana Cebrian, a physicist at the University
of Zaragoza in Spain who works on another
replication attempt, called ANAIS, in the Canfranc Underground Laboratory in the Pyrenees.
While early initiation
of ART did
result in a delay in the time to viral rebound (the time it takes for virus
replication to be observed in the blood following cessation
of ART) as compared with later treatment, the inability to eradicate the viral reservoir with very early initiation
of ART suggests that additional strategies will be needed to cure HIV infection.
Marketing professors Leif Nelson at U.C. Berkeley and Carnegie Mellon University's Jeff Galak failed to get positive
results from a
replication of the test involving erotic images, and experimental psychologist Richard Wiseman
of the University
of Hertfordshire in England failed to reproduce the outcome
of the word recall test.
Beyond repair and
replication processes, ribonucleotides can also be created in DNA as a
result of damage caused by drugs, environmental stressors and other factors.
Holstege says the other remarkable finding was that the mutations within the blood cells were harmless — all
resulted from mistaken
replication of DNA during van Andel - Schipper's life as the «mother» blood stem cells multiplied to provide clones from which blood was repeatedly replenished.
«Such
replication adds a tremendous amount
of robustness to the
results,» Raes emphasizes.
Their
results show that H. pylori affects both mitochondrial transport systems (used to transfer proteins into mitochondria) and the machinery for the
replication and maintenance
of the mitochondrial genome.
The
replication crisis refers to a growing concern in experimental psychology — and the larger scientific community — about the drop in studies able to confirm previous work with experiments that achieve the same
results using the same methods, as well as the increased risk
of data manipulation in studies with small sample sizes.
Vitamin C is known to keep some kinds
of cell
replication in check, so Benjamin Neel at the New York University School
of Medicine probed its effects in mice engineered to have low TET2 activity and a high
resulting cancer risk.
This
Replication Study has reproduced important parts
of the original paper, but it also contains
results that are not consistent with some parts
of the original paper.
This may make a difference in the effect size and will be included in the discussion
of the
results of the
replication.
For each paper a Registered Report detailing the proposed experimental designs and protocols for the
replications is peer reviewed and published prior to data collection; the
results of these experiments are then published as a
Replication Study.
As Carmen Buchrieser, head
of the Biology
of the intracellular bacteria research unit at the Institut Pasteur and researcher at CNRS, explains: «this is an important discovery as our
results showcase a key strategy used by L. pneumophilia for intracellular
replication.
The Reproducibility Project: Cancer Biology is a collaboration between the Center for Open Science and Science Exchange, and the
results of the
replications will be published by eLife.
This visual abstract depicts the findings
of McKimmie and colleagues, who show that inflammation at bite sites aids viral
replication and dissemination in vivo,
resulting in more severe infection.
NIH Principal Deputy Director Lawrence Tabak applauded the first
replication results, saying they «highlight some
of the incredible complexity that biology affords us and are reminders
of how important it is to use rigorous methods that are completely transparent.»
The
results of these experiments have now been published as a
Replication Study (Horrigan et al., 2017).
The Reproducibility Project: Cancer Biology is a collaboration between the Center for Open Science and Science Exchange, and the
results of the
replications will be published in eLife.
In addition,
replication of positive
results in larger trials is costly, and NIMH is constrained by limited funding and a budget that has lagged well behind inflation over the last decade.