Sentences with phrase «replication origins»
"Replication origins" refer to specific locations on a DNA molecule where DNA replication begins. These origins act as starting points for the copying process to ensure that the DNA molecule is accurately replicated before it can divide and pass on genetic information to new cells or organisms. Full definition
What determines the replication program, i.e. the position, the time of firing and the efficiency of replication origins in the human genome?
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Matson JP, Dumitru R, Coryell P, et al., Rapid DNA replication origin licensing protects stem cell pluripotency.
Review of «Rapid DNA replication origin licensing protects stem cell pluripotency» from eLife by Stuart P. Atkinson
«Under normal conditions, there are many more replication origins than are actually used.
We have discovered that in normal cells, the aberrant replication origins are subsequently eliminated.
«Initially, the cell identifies all potential replication origins with a molecular marker.
The molecular dialogue leading to the activation of replication origins must be strictly controlled in order to prevent replication from occurring too rapidly, thus overloading the system.
«The replication and transcription machineries are therefore active simultaneously on genes carrying a replication origin, which causes conflicts.
The activation of the oncogenes Cyclin E or Myc, on the other hand, induces the cells to begin replication of their DNA prematurely, without having had time to eliminate all the replication origins present in the genes.
The position and spacing of these sites, called «replication origins», must be controlled to ensure that replication takes place in a smooth and efficient way.
Our future work aims to uncover the molecular mechanisms linking transcription status of large genes to the organization of chromatin loops by their regulatory sequences, and how these features impact the setting of replication origins and CFS instability.
The replication (green) and transcription (brown) machineries are simultaneously active on the genes carrying a replication origin, resulting in collisions and DNA breaks.
A transition from rightward - to leftward - moving forks occurs when crossing a replication origin position, leading to an upward transition in the RFD profile (Fig. 1).
Drosophila P elements preferentially transpose to replication origins.