In a larger
replication study of the six - session treatment protocol with 21 couples, significant positive changes were found on the Marital Satisfaction Inventory (Hannah, Luquet, et al 1997).
FIREPAW researchers assisted colleagues in the Bahamas in providing supporting statistics for
their replication study of the FIREPAW research study on Companion Animals Guardians vs. Owners.
Not exact matches
At the Salk Inst.itute for Biological
Studies, in 1994, Leslie Orgel observes, «Because synthesizing nucleotides and achieving
replication of RNA under plausible prebiotic conditions have proved so challenging, chemists are increasingly considering the possibility that RNA was not the first self replicating molecule...» (9).
«The philosophical question that has not been answered in origin -
of - life
studies is this: How can a universe
of mindless matter produce beings with intrinsic ends, self -
replication capabilities, and «coded chemistry»?
Comparison
of two strategies to improve infant sleep problems, and associated impacts on maternal experience, mood and infant emotional health: a single case
replication design
study.
Finally, a Finnish trial
of universal home visiting by nurses35 and two U.S. programs implemented by master's degree - level mental health or developmental clinicians have found significant effects on a number
of important child behavioural problems.36, 37 Additionally, a paraprofessional home visitation program found effects on externalizing and internalizing behaviours at child age 2; however due to the large number
of effects measured in this
study,
replication of the findings is warranted.38
Although most
studies of parental depression have focused on mothers, the impact
of depression in fathers has received increasing attention.2, 3 Using data from the 2002 National Comorbidity
Replication Survey, the Institute
of Medicine report also estimated that 4.3 %
of men with a child under 18 years old had a major depressive disorder within the previous 12 months.1 In addition, a recent meta - analysis4 suggested that the prevalence
of paternal depression within the first year
of a child's life was 10.4 %.
In the biggest
replication effort so far, «[i] n a report published in Science in August, 270 psychologists orchestrated a repeat
of 100
studies published in three top journals.»
By the time he graduated from University College London in 1999, Godinho Ferreira had grown tired
of studying replication because the field had reached the point where «people would just repeat each others» experiments,» he says.
Molecular biology is the
study of molecular underpinnings
of the process
of replication, transcription and translation
of the genetic material.
«Is it because the original
study was wrong, because the
replication was screwed up or because
of an important difference between the original and the
replication?»
«They drew an unrepresentative sample
of studies, failed to ensure that
replications were faithful and then misanalyzed their own data.»
The MIME method is groundbreaking in the
study of viral
replication.
Eventually, with all the
replications [
of the
study], people now recognize that one
of the main pathologies in addiction is in the prefrontal cortex.
A new
study by Robert Stahelin, an adjunct associate professor
of chemistry and biochemistry at the University
of Notre Dame and an associate professor at the Indiana University School
of Medicine - South Bend, as well as a member
of Notre Dame's Eck Institute for Global Health, investigates how the most abundant protein that composes the Ebola virus, VP 40, mediates
replication of a new viral particle.
The tools were
studied by Dr. Harmand and her colleague Hélène Roche — world experts in lithic analysis, the
study of stone artifacts from the various Stone Age periods in which they were made — to interpret physical features and reconstruct the manufacturing techniques used at the prehistoric site, including experimental
replication of the tools.
On 20 December, the United States government — acting on advice from the US National Science Advisory Board for Biosecurity (NSABB)-- asked both journals to publish only the main conclusions
of two flu
studies, but not to reveal details «that could enable
replication of the experiments by those who would seek to do harm» (see «Call to censor flu
studies draws fire»).
Despite this thoroughness, while 97
of the original
studies reported significant results, only 35
of the
replications reported the same.
The new
study revealed the Ebola VP40 protein assumes different structures to perform multiple roles in the virus's life cycle — membrane trafficking, virus assembly and control
of replication.
Replication The Science Journals encourage the submission of replication studies that provide new insights into previously publish
Replication The Science Journals encourage the submission
of replication studies that provide new insights into previously publish
replication studies that provide new insights into previously published results.
Second, they considered the remaining SAGES
study sample to identify 36 matched pairs
of cases and controls, called the
replication cohort.
«Whenever anybody stops HAART, the virus comes back,» says Robert Siliciano, who
studies the dynamics
of HIV
replication at the Howard Hughes Medical Institute and Johns Hopkins University School
of Medicine.
University
of Virginia psychology professor Brian Nosek and his colleagues at the nonprofit Center for Open Science got help from over 350 scientists to repeat 100 high - profile psychology experiments published in 2008 — the largest
replication study to date.
Our independent scientific advisory board — all members
of which are leaders in their fields as well as advocates on the reproducibility problem — selects
studies for
replication.
Analytic methods (code) transparency The Science Journals require the Materials and Methods section to provide sufficient detail to allow
replication of the
study.
«Isn't it plausible that many or most
of the cancers attributed to
replication errors in this
study involve genetic or environmental factors that are too ubiquitous to be identified as such?»
The authors caution that further
study and
replication of their results in different populations is needed to verify their model before it will be useful for individual genetic tests — or before longevity «cocktails» are created.
«Oprl1 may be one
of the many genes that contribute risk, though larger samples and
replication studies are required to be certain
of this.»
In
studies with human fibroblasts that make up connective tissue, Boger's team tested whether NOD1 activity could affect CMV
replication in cultures
of cells grown in the lab.
These included tests for how much variance surrounded the main statistics
of the
studies, the sample size, the likelihood
of replication, and the estimated power
of the tests before and after the data was collected.
Fishel and Kolodner had been
studying the bacteria and yeast genes involved in the repair process that operates when base pairs slip out
of alignment during
replication, producing mismatches
of bases.
Despite decades
of study, until these experiments scientists did not fully understand the molecular mechanisms that cells use to transduce information about environmental conditions to their
replication machinery.
The oldest
study up for
replication is one published in Science in 1960 by Eckhard Hess and James Polt
of the University
of Chicago in Illinois.
So the team made their intentions public by preregistering their
study and submitting the idea to a special issue
of Social Psychology focused on experimental
replication slated to come out in spring 2014.
Over the years, he's seen a number
of ways in which
replication studies can go wrong in career terms.
But doing a
replication study just for the sake
of checking whether the original author made a mistake isn't smart, he says.
The trick, he says, is in seeing
replication not as an end in itself but as a means for acquainting yourself with the methods used in a
study, the original author's line
of thinking, the complications he or she must have faced, and the solutions they devised to those problems.
The results highlight the importance
of careful observation and controls, as well as the potential benefits
of replication studies.
The standards include citation standards for journals, data transparency, analytic methods (code) transparency, research materials transparency, design and analysis transparency, preregistration
of studies, preregistration
of analysis plans and
replication.
The authors
of the
study stress the importance
of replication using other datasets.
Dr. Jones obtained his Ph.D. in 2003 from the University
of Birmingham Institute
of Cancer and Genomic Sciences (United Kingdom) under Professor Lawrence Young,
studying the use
of gene therapy for targeting Epstein - Barr Virus (EBV) proteins with
replication - competent adenoviruses to treat EBV - driven malignancies.
and the answer, according to the results
of this
replication study, is yes.
It also undergoes cell division by first creating copies
of chromosomes like most human cells and has a very fast
replication cycle, all
of which facilitated the
study.
Less
replication of the virus means the infected person may experience less disease or is less likely to spread the disease to someone else, says Sabra Klein, PhD,
of Johns Hopkins University and lead investigator
of the
study.
«It's an almost exact
replication of the
study we did, and the apes appear to pass.
From such
studies came the current canonical model
of how venom genes evolve through the chance
replication and mutation
of genes for enzymes, peptides and other proteins.
However, the new, larger
study found that the effect
of viral
replication capacity was very early after infection, and was independent
of both initial viral load and whether individuals carried certain protective variants
of immune genes called HLA that positively influence immune responses to HIV.
Previous
studies in the lab showed that once HCMV is inside the cell, it quickly becomes latent by entering the cell's nucleus and co-opting a cellular protein called Daxx — part
of the intrinsic immune system — to shut down its own
replication, the process
of reproducing its genetic material to make more copies
of itself.
«We now have clues to how that double - ring structure stably lingers until the cell enters the DNA - synthesis phase much later on in
replication,» said
study coauthor Christian Speck
of Imperial College, London.
The findings reinforce the importance
of priming effects in gaming and virtual contexts, and the importance
of study replication.