Telomere length predicts
replicative capacity of human fibroblasts.
Extensive
replicative capacity of human central memory T cells.
This suggests that both ccr5 and cxcr4 can be genetically targeted simultaneously for the treatment of HIV infection, while preserving
the replicative capacity of the CD4 + T cells.
The results confirmed the team's previous finding that
the replicative capacity of the newly established virus drives how quickly infected individuals» levels of CD4 T cells declined.
The gradual shrinking of telomeres negatively affects
the replicative capacity of human adult stem cells, the cells that restore damaged tissues and / or replenish aging organs in our bodies.
Not exact matches
People infected with viruses with high
replicative capacity had more signs
of acute inflammation in the first few months
of infection.
«This suggests lowering viral
replicative capacity and the resulting immune activation might have benefits, in terms
of morbidity and mortality, for individuals whether they remain treatment naïve or go on antiretroviral therapy.
«These results reinforce our previous findings suggesting that interventions that affect
replicative capacity can not only impact disease progression, but also the efficiency
of transmission to other people,» says senior author Eric Hunter, co-director
of the Emory Center for AIDS Research, Georgia Research Alliance Eminent Scholar and a professor
of pathology and laboratory medicine at Emory University School
of Medicine.
A vaccine that targets qualities
of the virus responsible for
replicative capacity could have an important impact on disease progression and secondary transmission.»
«The effect
of viral
replicative capacity is just as big as, and independent from, the effect
of well - studied protective HLA alleles, which influence whether someone is likely to become an «elite controller,»» says Daniel Claiborne, lead author and postdoctoral fellow.
The holoclone contains tightly packed small cells and has the greatest
replicative capacity, and < 5 %
of the colonies formed by the cells
of a holoclone abort and terminally differentiate.