They specifically found that blue light, found in sunlight, makes T cells move faster — marking the first
report of a human cell responding to sunlight by speeding its pace.
Not exact matches
This technique has been used, as Arnold
reports, to trace the progress
of cancers, advance our understanding
of obesity and diabetes, and prove that brain
cells continue to form through a
human being's lifetime.
research; since most
of the
reports have concentrated on justifying the creation
of cloned
human embryos for research into and treatment
of neurodegenerative diseases such as Parkinson's, «stem -
cells» has become synonymous with «embryonic stem -
cells» in the public imagination.
Then a team
of Chinese researchers used that base editor to correct a mutation in
human embryos that causes the blood disorder beta - thalassemia,
reported September 23 in Protein &
Cell (SN: 11/25/17, p. 7).
As
reported June 13 in
Cell Reports, a topical drug penetrated and tanned laboratory samples
of live
human skin, absent the sun.
In 2007, however, scientists at International Stem
Cell, a California - based biotech firm, reported the first successful creation of human stem cell lines from unfertilized e
Cell, a California - based biotech firm,
reported the first successful creation
of human stem
cell lines from unfertilized e
cell lines from unfertilized eggs.
(A successful derivation
of stem
cells from a cloned
human embryo was not
reported until October 2011, and these stem
cells had three sets
of chromosomes rather than two.)
In this latest advance
reported in PNAS, the Wyss team showed that the
human gut - on - a-chip's unique ability to co-culture intestinal
cells with living microbes from the normal gut microbiome for an extended period
of time, up to two weeks, could allow breakthrough insights into how the microbial communities that flourish inside our GI tracts contribute to
human health and disease.
Human papillomavirus 16 accounts for about half
of all cervical cancers, but researchers
reporting September 7 in the journal
Cell have found that not all infections are equal.
In today's issue
of Cell, a team
reports that it has found in mice and
humans a close relative
of a fruit fly clock gene — the first evidence that some
of these genes may have been conserved over the course
of evolution.
Human cells don't respond to Fel d 1 alone, researchers at the University
of Cambridge in England
reported in July.
Components
of indoor dust may signal
human fat
cells to grow and may alter metabolism, potentially contributing to weight problems, researchers
report July 14 in Environmental Science & Technology.
Eighteen adults with severe eye disease who were among the first people to receive transplants created from
human embryonic stem
cells (hESCs) continue to have no apparent complications with the introduced
cells after an average
of nearly 2 years, according to the latest status
report on their health.
He
reports that Advanced
Cell Technology plans to clone genetically altered animals whose neural tissue would be immunologically compatible with that
of humans.
Last June Ingber's team
reported that it had placed
human lung lining
cells and
human capillary
cells on either side
of a porous, flexible polymer membrane.
The process,
reported in
Human Reproduction, utilizes DNA fingerprinting (an assessment
of active genes in a given
cell) to boost the success rate
of IVF and lower the chances
of risky multiple births by identifying which
of several five - day - old embryos are most likely to result in pregnancy The new method, which will replace unproved alternatives such as choosing embryos based on their shape, is likely to up the success
of women becoming pregnant and lower their chances
of having multiple births.
Unlike
humans, who use their lymphatic systems to produce and transport white blood
cells, tuna use theirs to move two
of their fins, researchers
report today in Science.
Investigators at Johns Hopkins
report they have developed
human induced - pluripotent stem
cells (iPSCs) capable
of repairing damaged retinal vascular tissue in mice.
Now a team led by Robin Weiss
of London's Institute
of Cancer Research
reports that the «PK» porcine endogenous retrovirus, which does not appear to harm pigs, can replicate in mink and
human cells.
► The U.S. National Institutes
of Health (NIH) has put funding on hold for experiments that involve «mixing
human stem
cells into very early animal embryos and letting them develop» while it «reconsiders its rules» for this type
of research, Gretchen Vogel
reported Wednesday.
Tufts University biomedical engineers recently published the first
report of a promising new way to induce
human mesenchymal stem
cells (or hMSCs, which are derived from bone marrow) to differentiate into neuron - like
cells: treating them with exosomes.
In May 2005, Hwang and his colleagues
reported that it had produced 11 new
human embryonic stem (ES)
cell lines that carried the genetic signature
of patients with diabetes, spinal cord injury, or a genetic blood disorder (Science, 20 May, p. 1096).
The
report, from a committee made up
of 11 members
of Parliament, also recommends legalizing research involving embryos
of chimeras and hybrids, which includes
cells created by fusing
human and animal nuclei.
The laboratory process, described in the journal Scientific
Reports, entails genetically modifying a line
of human embryonic stem
cells to become fluorescent upon their differentiation to retinal ganglion
cells, and then using that
cell line for development
of new differentiation methods and characterization
of the resulting
cells.
Tests with kidney cancer and two
human uterine sarcoma
cell lines, one with multidrug resistance, showed that 10
of these new compounds were impressively potent against all three
cell lines, the researchers
reported.
Prof Robin Lovell Badge, Crick Institute, on the science: «The experiments
reported by Junjiu Huang and colleagues (Liang et al) in the journal Protein
Cell on gene editing in abnormally fertilised
human embryos are, I expect, the first
of several that we will see this year.
Specifically, the study —
reported online in The Journal
of Infectious Diseases — shows that E. coli K1 modulates the protein peroxisome proliferator - activated receptor - gamma (PPAR - γ) and glucose transporter - 1 (GLUT - 1) levels at the blood - brain barrier in
human brain microvascular endothelial
cells.
The researchers, who
report their work in the 26 October issue
of Molecular
Cell, hope to soon create an altered version
of the protein that will work in
humans.
For instance, CiRA's Kohei Yamamizu recently
reported developing a cellular model
of the blood — brain barrier made entirely from
human iPS
cells.
The UC team first
reported how to use CRISPR in pieces
of circular DNA called plasmids that can invade bacteria, but the Broad won a race to apply the method to
human cells, which represents a potential billion - dollar marketplace for medicines.
In a
report that appears in PLOS BIOLOGY, Dr. Hugo Bellen and his colleagues at Baylor College
of Medicine and the Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital and BCM, and Dr. Chao Tong, at the Life Sciences Institute and Innovation Center for
Cell Biology, Zhejiang University in Hangzhou, China, find that mutations
of human homologs (genes that carry out similar functions)
of cacophony and its partner straightjacket (Cacna1a and Cacna2d2 respectively) cause defects in autophagy in neurons.
The results, which are published in the scientific journal Scientific
Reports, show that
human stem
cells that are transplanted to the injured spinal cord contribute to restoration
of some sensory functions.
In contrast, a team led by the Broad's Feng Zhang
reported in the 3 January 2013 online edition
of Science that it had used CRISPR to cut DNA in
human cells, opening the door for the tool to be used in medicine.
In a paper published online yesterday in Stem
Cells, the researchers report that they succeeded in generating pluripotent human ES cell lines — i.e., cells that can develop into many different kinds of cells — from one of the 13 late - arrested emb
Cells, the researchers
report that they succeeded in generating pluripotent
human ES
cell lines — i.e.,
cells that can develop into many different kinds of cells — from one of the 13 late - arrested emb
cells that can develop into many different kinds
of cells — from one of the 13 late - arrested emb
cells — from one
of the 13 late - arrested embryos.
Svetlana Glushakova, a
cell biologist at the National Institute of Child Health and Human Development in Bethesda, Md., reported the finding December 9 at the annual meeting of the American Society for Cell Biol
cell biologist at the National Institute
of Child Health and
Human Development in Bethesda, Md.,
reported the finding December 9 at the annual meeting
of the American Society for
Cell Biol
Cell Biology.
In laboratory studies
reported in the Proceedings
of the National Academy
of Sciences (PNAS), the researchers found that these «neutralizing» antibodies prevented a key part
of the virus, known as MERS CoV, from attaching to protein receptors that allow the virus to infect
human cells.
Another is that the transplanted bits
of tumor act nothing like cancers in actual
human brains, Fine and colleagues
reported in 2006: Real - life glioblastomas grow and spread and resist treatment because they contain what are called tumor stem
cells, but tumor stem
cells don't grow well in the lab, so they don't get transplanted into those mouse brains.
Two groups
of researchers
report today that washing
human skin
cells in similar cocktails
of four genes enabled them to reprogram the
cells to resemble those harvested from embryos.
The Ogretmen laboratory screened previously
reported microarray data sets
of several
human tumor tissues (metastatic head and neck squamous
cell carcinoma, melanoma, and renal
cell carcinoma) and showed that, in these samples, only the levels
of CerS4 were significantly decreased.
Now Yamanaka and his colleagues
report in the journal
Cell that the same combination
of genes induced pluripotency in commercially available
human fibroblasts (connective tissue
cells that play a crucial role in healing) derived from the facial skin
of a 36 - year - old woman, the joint tissue
of a man, aged 69, and a newborn, respectively.
Mouse embryonic stem
cells,
reported in 1981 by Martin Evans, Matthew Kaufman, and Gail Martin, have allowed scientists to generate genetically customized strains
of mice that have revolutionized studies
of organismic development and immunity and have provided countless models
of human disease.
George Daley, speaking
of potential therapeutic testing
of parthenote - derived stem
cells (the sort that his lab
reported isolating last December), said it was «reasonable» to assume that the technology wouldn't be ready for
human testing for another seven years.
It was found that complex II activity significantly declined with age, per unit
of mitochondria, in the
cells derived from the lower rather than the upper levels, an observation not previously
reported for
human skin.
At a symposium at The American Society
of Human Genetics here last month, they
reported zooming in on the genes expressed in a single brain
cell, as well as panning out to understand how genes foster connections among far - flung brain regions.
Now scientists in the laboratory
of Jan Karlseder, a professor in Salk's Molecular and
Cell Biology Laboratory and holder
of the Donald and Darlene Shiley Chair,
report the first experimental induction
of an ALT telomere - building program in
human cells.
Even more encouraging, the engineered tissues still continued to produce
human neural, cartilage, and liver
cell proteins, the team
reports online this week in the Proceedings
of the National Academy
of Sciences.
The ethics council finally issued its 20 - page
report just before Christmas, voting in favor
of allowing the import
of human embryonic stem
cells, under certain conditions, by a small majority
of 15 to 9, paving the way for next week's final showdown.
And many
of the highlighted
human genes are associated with the same critical cellular operations, such as the
cell's protein - building factories, as in those species, MacArthur's group
reports.
The new technique — called DNA Programmed Assembly
of Cells (DPAC) and reported in the journal Nature Methods on August 31, 2015 — allows researchers to create arrays of thousands of custom - designed organoids, such as models of human mammary glands containing several hundred cells each, which can be built in a matter of h
Cells (DPAC) and
reported in the journal Nature Methods on August 31, 2015 — allows researchers to create arrays
of thousands
of custom - designed organoids, such as models
of human mammary glands containing several hundred
cells each, which can be built in a matter of h
cells each, which can be built in a matter
of hours.
CPF1 from two
of these bacteria were able to edit DNA in
human cells, Zhang's team
reports online today in
Cell.