Sentences with phrase «reported in human disease»

Additionally, the inflammatory profile of endometriosis in this animal model mirrors what has been reported in human disease [35 - 37] making this an excellent parallel study for our currently reported data.

Not exact matches

research; since most of the reports have concentrated on justifying the creation of cloned human embryos for research into and treatment of neurodegenerative diseases such as Parkinson's, «stem - cells» has become synonymous with «embryonic stem - cells» in the public imagination.

Bacteria found in humans, animals and food continue to show resistance to widely used antimicrobials, says the latest report on antimicrobial resistance (AMR) in bacteria by the European Food Safety Authority (EFSA) and the European Centre for Disease Prevention and Control (ECDC).

Former EPA Region 2 Administrator Judith Enck, who was featured in the Politico article and is also a regular voice on WAMC, called the actions by EPA and the Department of Defense «scientific censorship» of the report being compiled by the Department of Health and Human Services» Agency for Toxic Substances and Disease Registry.

But in March, Lichun Tang of China's Beijing Proteome Research Center and colleagues reported using CRISPR / Cas9 to correct disease - causing mutations in a small number of viable human embryos.

A recent study published in Annals of Neurology reports that healthy human tissue grafted to the brains of patients with Huntington's disease in the hopes of treating the neurological disorder also developed signs of the illness, several years after the graft.

In this latest advance reported in PNAS, the Wyss team showed that the human gut - on - a-chip's unique ability to co-culture intestinal cells with living microbes from the normal gut microbiome for an extended period of time, up to two weeks, could allow breakthrough insights into how the microbial communities that flourish inside our GI tracts contribute to human health and diseasIn this latest advance reported in PNAS, the Wyss team showed that the human gut - on - a-chip's unique ability to co-culture intestinal cells with living microbes from the normal gut microbiome for an extended period of time, up to two weeks, could allow breakthrough insights into how the microbial communities that flourish inside our GI tracts contribute to human health and diseasin PNAS, the Wyss team showed that the human gut - on - a-chip's unique ability to co-culture intestinal cells with living microbes from the normal gut microbiome for an extended period of time, up to two weeks, could allow breakthrough insights into how the microbial communities that flourish inside our GI tracts contribute to human health and disease.

• In other funding news, the National Institutes of Health announced a new $ 17 million program to investigate whether extracellular RNA plays an important signaling role in people, and whether it can be harnessed to diagnose and treat human diseases, Mitch Leslie reports in News & AnalysiIn other funding news, the National Institutes of Health announced a new $ 17 million program to investigate whether extracellular RNA plays an important signaling role in people, and whether it can be harnessed to diagnose and treat human diseases, Mitch Leslie reports in News & Analysiin people, and whether it can be harnessed to diagnose and treat human diseases, Mitch Leslie reports in News & Analysiin News & Analysis.

The journal provides cutting - edge research including results from animal models that are likely to apply to patients, studies in human tissue that provide new information about therapies or disease, and innovative reports of drug discovery and development.

Scientists report that domestic pigs harbor Reston ebolavirus, the only Ebola species that has not caused disease in humans

The finding, reported in next month's issue of Nature Medicine, raises new questions about whether people could contract exotic diseases if animal organs become routinely transplanted into human patients.

«We're part of medicine now,» Leslie Biesecker, chief of the Genetic Disease Research Branch at the National Human Genome Research Institute in Bethesda, Maryland, and co-chair of the ACMG working group that wrote the report, told Science at the time.

«We're part of medicine now,» Leslie Biesecker, chief of the Genetic Disease Research Branch at the National Human Genome Research Institute in Bethesda, Maryland, and co-chair of the ACMG working group that wrote the report, told

Concerns have been stirred by reports of research in China to correct disease - causing genetic mutations in non-viable embryos in 2015 and the granting, by the Human Fertilisation and Embryology Authority (HFEA), of a licence to allow genome editing of embryos in the UK February 2016.

Poor Maria also harbored human papillomavirus in a venereal wart — the first diagnosis of this sexually transmitted, cancer - causing disease in the tissue of a mummy, Fornaciari reported in a 2006 paper.

It was eggshell thinning that devastated fish - eating birds and birds of prey, says Fry, and this effect is well documented in a report (pdf) on DDT published in 2002 by the Department of Health and Human Services» Agency for Toxic Substances and Disease Registry (ATSDR).

The method, reported in the November issue of Nature Biotechnology, could lead to safe and effective human gene therapies for cystic fibrosis, hemophilia, and a variety of other diseases.

«Using a technique developed by our collaborators at the University of Iowa, we were able to get long - term expression of these human gene variants in the fluid that bathes the entire brain,» says Bradley Hyman, MD, PhD, of the MassGeneral Institute for Neurodegenerative Disease (MGH - MIND), senior author of the report in the Nov. 20 Science Translational Medicine.

In such a scenario, disease risk to humans would rise 10-fold, the team reports in a preprint posted this week to bioRxiIn such a scenario, disease risk to humans would rise 10-fold, the team reports in a preprint posted this week to bioRxiin a preprint posted this week to bioRxiv.

Mouse embryonic stem cells, reported in 1981 by Martin Evans, Matthew Kaufman, and Gail Martin, have allowed scientists to generate genetically customized strains of mice that have revolutionized studies of organismic development and immunity and have provided countless models of human disease.

In a novel animal study design that mimicked human clinical trials, researchers at University of California, San Diego School of Medicine report that long - term treatment using a small molecule drug that reduces activity of the brain's stress circuitry significantly reduces Alzheimer's disease (AD) neuropathology and prevents onset of cognitive impairment in a mouse model of the neurodegenerative conditioIn a novel animal study design that mimicked human clinical trials, researchers at University of California, San Diego School of Medicine report that long - term treatment using a small molecule drug that reduces activity of the brain's stress circuitry significantly reduces Alzheimer's disease (AD) neuropathology and prevents onset of cognitive impairment in a mouse model of the neurodegenerative conditioin a mouse model of the neurodegenerative condition.

So far there have been no reports of Parkinson's disease in human survivors of the H5N1 flu, Smeyne says, but because only a few years have passed since the first cases were reported, it's too early to know whether those infected are at increased risk.

Their findings, reported in Nature Communications, may shed light on human lung disease, in particular, the mechanism behind non-familial pulmonary hypertension in patients with conditions such as emphysema and pulmonary fibrosis.

Researchers report in Nature today that they have perfected a way to manufacture monoclonal antibodies capable of destroying diseases such the avian flu, which have the ability to swap genes with human flu varieties and jump from birds to people.

Dartmouth researchers developed a new biological pathway - based computational model, called the Pathway - based Human Phenotype Network (PHPN), to identify underlying genetic connections between different diseases as reported in BioDataMining this week.

A computational tool developed at the University of Utah (U of U) has successfully identified diseases with unknown gene mutations in three separate cases, U of U researchers and their colleagues report in a new study in The American Journal of Human Genetics.

Working with mouse, fly and human cells and tissue, Johns Hopkins researchers report new evidence that disruptions in the movement of cellular materials in and out of a cell's control center — the nucleus — appear to be a direct cause of brain cell death in Huntington's disease, an inherited adult neurodegenerative disorder.

After Liu's initial report, a group in China used DNA base editing to correct a disease - causing mutation in human embryos cloned from a patient with a genetic blood disorder.

«Although many reports have addressed the effect of lactic acid bacteria on skin properties in subjects with skin diseases, such as atopic dermatitis, few studies have involved healthy humans,» explains lead investigator Hiromi Kimoto - Nira, PhD, of the National Agriculture and Food Research Organization (NARO) Institute of Livestock and Grassland Science (NILGS), Tsukuba, Japan.

They searched through 60 years of scientific and newspaper reports to determine two things: first, whether the pathogens cause visible disease symptoms or death in wildlife, and second, whether human outbreaks were preceded or accompanied by evidence of the disease in animals.

To reduce false positives when identifying genetic variations associated with human disease through genome - wide association studies (GWAS), Dartmouth researchers have identified nine traits that are not dependent on P values to predict single nucleotide polymorphisms (SNP) reproducibility as reported in Human Genetics on October 2, human disease through genome - wide association studies (GWAS), Dartmouth researchers have identified nine traits that are not dependent on P values to predict single nucleotide polymorphisms (SNP) reproducibility as reported in Human Genetics on October 2, Human Genetics on October 2, 2014.

The finding, by researchers at the University of Illinois at Chicago College of Medicine, was reported July 16 at the Alzheimer's Association International Conference in Copenhagen by Mary Jo LaDu, who in 2012 developed a transgenic mouse that is now regarded as the best animal model of the human disease.

The new NIST human genome RMs increase the ability of DNA sequencing laboratories to be more confident in their reporting of true positives, false positives, true negatives and false negatives, and therefore, significantly improve genetic tests used for disease risk prediction, diagnosis, and progression tracking.

The study, reported here at a Human Origins and Disease conference, will appear in an upcoming issue of Human Genetics.

From this research published in Scientific Reports, scientists aim to unravel the causes behind the disease in zebrafish and therefore provide new leads for a treatment for human LCA.

Last November, however, a team led by Mihael Polymeropoulos of the National Human Genome Research Institute in Bethesda, Maryland, reported that the disease afflicting the Italian family, which develops at an unusually early age, showed strong genetic linkage to a region on chromosome 4.

The test tube finding, reported in the current Cell, could help explain the formation of prions — the tangled proteins that are implicated in mad cow disease and several human brain disorders — and eventually may lead to a way to smooth out these rogue proteins.

The new flu, known as H7N9 avian influenza, latches onto sugars that coat bird cells — and it can cling to sugars on human cells too, Yuelong Shu of the China Center for Disease Control and Prevention and colleagues report July 3 in Nature.

The Search for Extraterrestrial Intelligence has always looked for an anomaly in the persistent cosmic background chatter — a change perhaps in the intensity of a signal that can be taken as a sign that a transmission might be a message to us earthlings from other intelligent beings.Each year, medical researchers who gather at the Alzheimer's Association International Conference search for something similar as they weigh reports of the complex biology of the human brain for some sign that a drug might actually change the relentless course of the disease.

In April 2015, researchers in China reported that they had used CRISPR, with limited success, to repair a disease - causing gene in human embryoIn April 2015, researchers in China reported that they had used CRISPR, with limited success, to repair a disease - causing gene in human embryoin China reported that they had used CRISPR, with limited success, to repair a disease - causing gene in human embryoin human embryos.

Coauthor Niyaz Ahmed, PhD, Professor of Biotechnology & Bioinformatics, University of Hyderabad, India, said that H. pullorum could potentially be pathogenic in poultry and in humans, and explained that cases have been reported of human enteric disease caused by this bacterium.

Although mutations had been identified in other genes important for the recycling of bile acids, this is the first report in humans of disease - associated defects in this gene, called Organic Solute Transporter - beta (SLC51B).

Despite recent successes in identifying causative mutations for human heritable diseases through the use of sequencing technologies, an associated gene has not been identified for approximately half of the reported diseases.

Blocking a factor that can activate the human immune response against intestinal bacteria or certain foods could prevent the development of celiac disease in those most at risk, researchers report in the journal Nature.

Russell Kern reports on the 6 - month update on the first - in - human clinical study of neural stem cells in patients with Parkinson's disease.

JCVI, in collaboration with UC San Diego, recently completed a report on «Policy and Regulatory Issues for Gene Drives in Insects» outlining specific suggestions that could help advance this promising approach for combatting insect - borne human disease and insect agricultural pests, while ensuring that environmental safety and societal issues are addressed.

PHENOMIN's involvement in the IMPC will fulfill a key item of the the National Alliance for life sciences and health (AVIESAN) strategic plan that consists in applying mouse genetics to analyze the mechanisms of disease and to use this knowledge for advancing fundamental research and human health (AVIESAN report on the use and needs of mouse models in the French scientific community, 2010).

«In a report published in the journal Lancet, scientists led by Dr. Robert Lanza, chief scientific officer at Advanced Cell Technology, provide the first evidence that stem cells from human embryos can be a safe and effective source of therapies for two types of eye diseases&raquIn a report published in the journal Lancet, scientists led by Dr. Robert Lanza, chief scientific officer at Advanced Cell Technology, provide the first evidence that stem cells from human embryos can be a safe and effective source of therapies for two types of eye diseases&raquin the journal Lancet, scientists led by Dr. Robert Lanza, chief scientific officer at Advanced Cell Technology, provide the first evidence that stem cells from human embryos can be a safe and effective source of therapies for two types of eye diseases»

Importantly, more that 400 different mutations in the lamin A gene have been reported, which are associated with a wide range of human degenerative diseases including muscular dystrophy, lipodystrophies and neuropathies.

In a substudy, review outcomes were also compared across different types of clinical research, based in large part on the designations and definitions derived from a number of sources, including a report by Nathan, 14 the Institute of Medicine, 20 the NIH Director's Panel on Clinical Research, 9 the Association of American Medical Colleges and American Medical Association, 21 and the Agency for Healthcare Research and Quality.22 All 3599 R01 applications involving human subjects that were submitted to NIH for the October 2002 council were categorized into 1 of the following: (1) patient - oriented studies of mechanisms of human disease (bench to bedside); (2) clinical trials and other clinical interventions; (3) patient - oriented research focusing on development of new technologies; (4) epidemiological studies; (5) behavioral studies (including studies of normal human behavior); (6) health services research; and (7) use of deidentified human tissuIn a substudy, review outcomes were also compared across different types of clinical research, based in large part on the designations and definitions derived from a number of sources, including a report by Nathan, 14 the Institute of Medicine, 20 the NIH Director's Panel on Clinical Research, 9 the Association of American Medical Colleges and American Medical Association, 21 and the Agency for Healthcare Research and Quality.22 All 3599 R01 applications involving human subjects that were submitted to NIH for the October 2002 council were categorized into 1 of the following: (1) patient - oriented studies of mechanisms of human disease (bench to bedside); (2) clinical trials and other clinical interventions; (3) patient - oriented research focusing on development of new technologies; (4) epidemiological studies; (5) behavioral studies (including studies of normal human behavior); (6) health services research; and (7) use of deidentified human tissuin large part on the designations and definitions derived from a number of sources, including a report by Nathan, 14 the Institute of Medicine, 20 the NIH Director's Panel on Clinical Research, 9 the Association of American Medical Colleges and American Medical Association, 21 and the Agency for Healthcare Research and Quality.22 All 3599 R01 applications involving human subjects that were submitted to NIH for the October 2002 council were categorized into 1 of the following: (1) patient - oriented studies of mechanisms of human disease (bench to bedside); (2) clinical trials and other clinical interventions; (3) patient - oriented research focusing on development of new technologies; (4) epidemiological studies; (5) behavioral studies (including studies of normal human behavior); (6) health services research; and (7) use of deidentified human tissue.