Sentences with phrase «reports of adverse effects»

Yoga appears to be a promising complementary therapy and stress - management tool for children and adolescents, with very low reports of adverse effects.

This report also mentions that the EPA has received reports of adverse effects in pets and promises further evaluation.

It is difficult to reconcile these statements with published scientific literature which is replete with reports of adverse effects and toxicity of isoflavones at dietary levels.

Although nicotine may be present in the milk of a mother who smokes, there are no reports of adverse effects on an infant due to breastfeeding.

Not exact matches

Important factors that could cause actual results to differ materially from those reflected in such forward - looking statements and that should be considered in evaluating our outlook include, but are not limited to, the following: 1) our ability to continue to grow our business and execute our growth strategy, including the timing, execution, and profitability of new and maturing programs; 2) our ability to perform our obligations under our new and maturing commercial, business aircraft, and military development programs, and the related recurring production; 3) our ability to accurately estimate and manage performance, cost, and revenue under our contracts, including our ability to achieve certain cost reductions with respect to the B787 program; 4) margin pressures and the potential for additional forward losses on new and maturing programs; 5) our ability to accommodate, and the cost of accommodating, announced increases in the build rates of certain aircraft; 6) the effect on aircraft demand and build rates of changing customer preferences for business aircraft, including the effect of global economic conditions on the business aircraft market and expanding conflicts or political unrest in the Middle East or Asia; 7) customer cancellations or deferrals as a result of global economic uncertainty or otherwise; 8) the effect of economic conditions in the industries and markets in which we operate in the U.S. and globally and any changes therein, including fluctuations in foreign currency exchange rates; 9) the success and timely execution of key milestones such as the receipt of necessary regulatory approvals, including our ability to obtain in a timely fashion any required regulatory or other third party approvals for the consummation of our announced acquisition of Asco, and customer adherence to their announced schedules; 10) our ability to successfully negotiate, or re-negotiate, future pricing under our supply agreements with Boeing and our other customers; 11) our ability to enter into profitable supply arrangements with additional customers; 12) the ability of all parties to satisfy their performance requirements under existing supply contracts with our two major customers, Boeing and Airbus, and other customers, and the risk of nonpayment by such customers; 13) any adverse impact on Boeing's and Airbus» production of aircraft resulting from cancellations, deferrals, or reduced orders by their customers or from labor disputes, domestic or international hostilities, or acts of terrorism; 14) any adverse impact on the demand for air travel or our operations from the outbreak of diseases or epidemic or pandemic outbreaks; 15) our ability to avoid or recover from cyber-based or other security attacks, information technology failures, or other disruptions; 16) returns on pension plan assets and the impact of future discount rate changes on pension obligations; 17) our ability to borrow additional funds or refinance debt, including our ability to obtain the debt to finance the purchase price for our announced acquisition of Asco on favorable terms or at all; 18) competition from commercial aerospace original equipment manufacturers and other aerostructures suppliers; 19) the effect of governmental laws, such as U.S. export control laws and U.S. and foreign anti-bribery laws such as the Foreign Corrupt Practices Act and the United Kingdom Bribery Act, and environmental laws and agency regulations, both in the U.S. and abroad; 20) the effect of changes in tax law, such as the effect of The Tax Cuts and Jobs Act (the «TCJA») that was enacted on December 22, 2017, and changes to the interpretations of or guidance related thereto, and the Company's ability to accurately calculate and estimate the effect of such changes; 21) any reduction in our credit ratings; 22) our dependence on our suppliers, as well as the cost and availability of raw materials and purchased components; 23) our ability to recruit and retain a critical mass of highly - skilled employees and our relationships with the unions representing many of our employees; 24) spending by the U.S. and other governments on defense; 25) the possibility that our cash flows and our credit facility may not be adequate for our additional capital needs or for payment of interest on, and principal of, our indebtedness; 26) our exposure under our revolving credit facility to higher interest payments should interest rates increase substantially; 27) the effectiveness of any interest rate hedging programs; 28) the effectiveness of our internal control over financial reporting; 29) the outcome or impact of ongoing or future litigation, claims, and regulatory actions; 30) exposure to potential product liability and warranty claims; 31) our ability to effectively assess, manage and integrate acquisitions that we pursue, including our ability to successfully integrate the Asco business and generate synergies and other cost savings; 32) our ability to consummate our announced acquisition of Asco in a timely matter while avoiding any unexpected costs, charges, expenses, adverse changes to business relationships and other business disruptions for ourselves and Asco as a result of the acquisition; 33) our ability to continue selling certain receivables through our supplier financing program; 34) the risks of doing business internationally, including fluctuations in foreign current exchange rates, impositions of tariffs or embargoes, compliance with foreign laws, and domestic and foreign government policies; and 35) our ability to complete the proposed accelerated stock repurchase plan, among other things.

These risks and uncertainties include, among others: the unfavorable outcome of litigation, including so - called «Paragraph IV» litigation and other patent litigation, related to any of our products or products using our proprietary technologies, which may lead to competition from generic drug manufacturers; data from clinical trials may be interpreted by the FDA in different ways than we interpret it; the FDA may not agree with our regulatory approval strategies or components of our filings for our products, including our clinical trial designs, conduct and methodologies and, for ALKS 5461, evidence of efficacy and adequacy of bridging to buprenorphine; clinical development activities may not be completed on time or at all; the results of our clinical development activities may not be positive, or predictive of real - world results or of results in subsequent clinical trials; regulatory submissions may not occur or be submitted in a timely manner; the company and its licensees may not be able to continue to successfully commercialize their products; there may be a reduction in payment rate or reimbursement for the company's products or an increase in the company's financial obligations to governmental payers; the FDA or regulatory authorities outside the U.S. may make adverse decisions regarding the company's products; the company's products may prove difficult to manufacture, be precluded from commercialization by the proprietary rights of third parties, or have unintended side effects, adverse reactions or incidents of misuse; and those risks and uncertainties described under the heading «Risk Factors» in the company's most recent Annual Report on Form 10 - K and in subsequent filings made by the company with the U.S. Securities and Exchange Commission («SEC»), which are available on the SEC's website at www.sec.gov.

The CBO report says postponing the tax increases and spending cuts «indefinitely» would «raise the risk of a fiscal crisis» that «would eventually» have adverse effects.

Delinquency can have an adverse effect on your credit rating, as we report the status of your loans to the consumer reporting agencies on a monthly basis.

There are other aspects of the NGP Report that merit further discussion, including its approach to adaptive management (we now have three different JRP reports in as many years that take different views on the extent to which AM can be relied upon in making a determination as to the likelihood of significant adverse environmental effects under CEAA), the precautionary principle, species at risk and Aboriginal consultation.

Any consequences resulting from inaccuracies or delays in our reported financial statements could have an adverse effect on the trading price of our common stock as well as an adverse effect on our business, operating results and financial condition.

HAZELTON — A federal environmental assessment report that concluded the proposed New Prosperity open - pit mine would have significant adverse effects for the Tsilhqot» in is a condemnation of the B.C. Liberals approach to Aboriginal rights and title, says Stikine MLA Doug...

The overwhelming consensus and the unanimous Scientific Advisory Committee's report indicate that television violence, indeed, does have an adverse effect on certain members of our society.

I thank Michael Knower for his insightful «on - the - ground» report as a palliative care physician in Oregon, which affords him firsthand experience with the adverse effects of the law permitting assisted suicide.

In its report, WHO notes that it does not include the sugars in fresh fruits and vegetables, or sugars naturally present in milk, because «there is no reported evidence of adverse effects of consuming these sugars.»

Earlier this year, the Food and Drug Administration released a report raising concerns about the possible adverse effects of BPA (Bisphenol - A).

Chemicals with estrogenic activity «have been reported to have potential adverse health effects in mammals, including humans, especially in fetal and infant states,» says Dr. George Bittner, a professor of neurobiology at the University of Texas at Austin who has served on many National Institutes of Health panels.

«It has not previously been reported that the use of analgesia via pudendal block has an adverse effect on the initiation of developing breastfeeding behavior including sucking.»

FDA: «FDA Drug Safety Communication: Reports of a rare, but serious and potentially fatal adverse effect with the use of OTC benzocaine gels and liquids applied to the gums or mouth.»

Twenty - nine percent of children 2 to 3 years of age have a television in their bedroom, and 30 % of parents have reported that watching a television program enabled their children to fall asleep.3 Although parents perceive a televised program to be a calming sleep aid, some programs actually increase bedtime resistance, delay the onset of sleep, cause anxiety about falling asleep, and shorten sleep duration.41 Specifically, in children younger than 3 years, television viewing is associated with irregular sleep schedules.42 Poor sleep habits have adverse effects on mood, behavior, and learning.

Two case reports and two small case series subsequently have provided reassuring evidence regarding the limited amount of drug transferred to the infant through breast milk and the lack of adverse side effects noted in infants by nursing mothers.5 — 8

There are now 400 reports of adverse side effects — including 10 deaths — associated with these products, according to the FDA.

FDA Drug Safety Communication: Reports of a rare, but serious and potentially fatal adverse effect with the use of over-the-counter (OTC) benzocaine gels and liquids applied to the gums or mouth.

Tough documents the devastating effects of adverse childhood experiences on children's ability to cope with stress, and he reports on recent educational programs to help students develop «non-cognitive» skills - grit, optimism, curiosity, zest, social intelligence, gratitude, and self - control — that are essential to success in life.

Cori Gambini, president of Communication Workers of America Local 1168, says numerous studies and reports, including one in 2011 by the New England Journal of Medicine, show the adverse effects of putting too many patients on too few nurses.

Volunteers reported mildly altered states of consciousness after receiving psilocybin but noted no adverse physiological effects.

published in APA's Journal of Occupational Health Psychology, women tend to report more adverse effects than men after experiencing workplace sexual harassment.

Patients in the clinical trial who got the combined therapies also had fewer serious adverse side effects than those who received only ipilimumab, the researchers report in the Journal of the American Medical Association.

Long - term use of mifepristone has been studied in clinical trials for other tumors, with minimal adverse effects reported after years of usage.

Professor Marco Metra, director of the Institute of Cardiology at the University and Civil Hospital of Brescia, Italy and co-principal investigator of RELAX - AHF, said: «We have reported that all of these adverse effects of a worsening heart failure event are related to increased overall mortality and that a worsening heart failure event itself is related to a two-fold increased risk of dying in 180 days.»

R. S. Sharma, a public health specialist on the panel from the Indian Council of Medical Research, writes in the report that, «the hot tropical climate of the country, the low body mass index; low fat content of an average Indian as compared to European countries and high environmental concentration of radio frequency radiation may place Indians under risk of radio frequency radiation adverse effect.»

«No significant safety concerns or dose - dependent adverse side effects of AVI - 7288 were reported with respect to any safety end point evaluated,» said Michael Wong, M.D., senior medical director for infectious diseases at Sarepta.

Standardized reporting could boost patient safety by identifying traditional treatments and combinations of traditional and conventional medications that have adverse effects.

They are always accompanied by anecdotal reports of heightened mental powers, and concerns about adverse health effects and unlevel playing fields.

For example, drugs as well - known as aspirin have different effects in men and women, and women report a higher rate of adverse reactions to drugs than do men.

Gulf War veterans with low - level exposure to chemical weapons show lasting adverse effects on brain structure and memory function, reports a study in the October Journal of Occupational and Environmental Medicine.

An international team led by metabolism experts Matthias Tschöp (Helmholtz Zentrum München / Technische Universität Müchen), Richard diMarchi (Indiana University) and Timo Müller (Helmholtz Zentrum München) report in the current issue of the journal Cell that liver - specific delivery of the thyroid hormone T3 using glucagon corrects obesity, glucose intolerance, fatty liver disease and atherosclerosis without causing adverse effects in other tissues.

«There is a growing consensus in the scientific community that small doses of pesticides and other chemicals can have adverse effects on health, especially during vulnerable periods such as fetal development and childhood,» reports author and physician Andrew Weil, a leading voice for so - called integrative medicine combining conventional and alternative medical practices.

A new report by the environmental group Greenpeace reveals that residents living in areas affected by the Chernobyl and Fukushima nuclear disasters continue to suffer from the adverse effects of radioactive contamination.

Okyanos therapies have been shown to be safe and efficacious in scientific and / or medical literature for the conditions we treat, and there have been zero reports of cell - related adverse effects using a patient's own adipose - derived stem and regenerative cells (ADRCs).

«Older children [aged 6 - 12 years] were more likely to report intentional ingestion and to have adverse health effects and worse outcomes than were younger children, suggesting that older children might be deliberately misusing or abusing alcohol hand sanitizers,» wrote the team led by Dr. Cynthia Santos, of the CDC's National Center for Environmental Health.

From the case reports, the incidence of lifethreatening effects appears to be low, but serious adverse effects may be underrecognized or underreported, especially since they may occur many years later.

Reports show black cohosh may also cause liver damage, however millions of people use the herb with no adverse side effects.

In a review of 33 different trials involving 4,459 participants with H. pylori, researchers reported that taking probiotics with triple therapy caused a higher success rate in treating H. pylori overgrowth — as well as fewer adverse effects.

Some populations that tend to report shorter periods of sleep, like the elderly, could be at an even greater risk of these adverse health effects.

One eight - month IER trial in obesity - prone rats reported an increase in theproduction of reactive oxygen species (ROS), with no clear mechanistic explanations.26 Another trial, this time over six months, showed that IER - fed rats displayed marked reductions in diastolic compliance and cardiac reserve due to observed reductions in cardiomyocyte size and increased myocardial fibrosis.23 No human trials to date have reported any adverse effects on cardiovascular health during long - term IER.

27 Studies cited by the 2010 DGAC Report demonstrate varied metabolic responses to lowered dietary saturated fat, with certain subpopulations exhibiting adverse rather than improved health outcomes.3 Two recent comprehensive meta - analyses indicate that saturated fat is not linked to heart disease.28, 29 In fact, in a definitive review of forty - eight clinical trials, with over sixty - five thousand participants, the reduction or modification of dietary fat had no effect on mortality, cardiovascular mortality, heart attacks, stroke, cancer, or diabetes.30 Yet, avoiding saturated fat remains a cornerstone of national dietary guidance.

The limited reports of complications arising from use of the modified Atkins diet (MAD) or low glycaemic index treatment suggest fewer and less serious adverse events when these more liberal modified diets are used (32, 33, 34, 35), although a prospective review of 6 MAD studies found 13 % of 92 children and adults discontinued the diet due to intolerance or side effects (36).

Although it is often suggested that children with epilepsy who are benefiting from ketogenic dietary therapy continue this for at least two years, duration of treatment could be shorter in patients with infantile spasms who become seizure - free; one study reported no adverse effect on seizure outcomes and less risk of growth disturbances when treatment was tapered down after 8 months (15).

Soy is reported as an accumulative endocrine disruptor capable of multiplying endocrine disruptor adverse effects.

Thyroglobulin is a sensitive measure of both deficient and excess iodine intakes in children and indicates no adverse effects on thyroid function in the UIC range of 100 - 299 micrograms / L: a UNICEF / ICCIDD Study Group Report.