DNA research: an international journal for rapid publication of
reports on genes and genomes.
Farkas et al. [29] and Ivanov et al. [30]
reported on gene expression profiling in purified populations of rat retinal ganglion cells.
Almost exactly a year ago,
we reported on a gene therapy for haemophilia that was in development by the Children's Hospital of Philadelphia (and subsequently the CHOP spinout Spark Therapeutics).
3 Annual Data
Report on Gene and Cellular Therapies and the Regenerative Medicine Sector.
This blawg keeps tabs on the U.S. Patent and Trademark Office, devours and analyzes draft
reports on gene patents, and speculates on what the Obama administration will mean to patent law.
Not exact matches
Spark Therapeutics» stock soared 20 % in Wednesday trading
on the heels of its second quarter 2017 earnings
report and some (very) early data
on the
gene therapy - focused firm's treatment for the blood disorder hemophilia A.
The company will now be able to sell health risk
reports on three variants found
on the BRCA1 and BRCA2
genes, which are linked with a higher risk of breast, ovarian, and prostate cancer.
The FDA's inspection
report «is based
on raw observations and in some cases lack proper context,»
Gene Grabowski, an outside spokesman for Rose Acre Farms, said in an email.
The biopharma world went into a bit of a frenzy
on Tuesday as Nature
reported that a team of Chinese scientists had become the first in the world to launch human trials of the groundbreaking CRISPR
gene - editing technology.
And
on Wednesday, in a major milestone for this burgeoning and potentially world - changing industry, the Dutch startup UniQure, developer of the Western world's first approved
gene therapy, raised $ 82 million in its initial public offering, Reuters
reports.
Keith Fargo, the Alzheimer's Association director of scientific programs and outreach, told Business Insider in 2017 that the Alzheimer's
report, which would tell me whether I had a mutation
on my APOE
gene, was more useful in the context of research than it was for predicting who might get the disease.
After
reporting second - quarter results that contained upbeat clinical news, Spark Therapeutics (NASDAQ: ONCE), a clinical - stage company focused
on gene therapy, rose 18 % as of 12:30 p.m. EDT
on Wednesday.
The 150 - page
report, released by state Inspector General Catherine Leahy Scott
on the one - year anniversary of the escape, goes into the detailed plannings of Matt and Sweat, including their efforts to recruit prison employees like seamstress Joyce Mitchell and corrections officer
Gene Palmer.
The Times Union
reports that the officer,
Gene Palmer, has been placed
on administrative leave as investigators look into whether the officer might have been duped into providing the tools or knowingly assisted the convicts.
Her work focuses
on topics ranging from neuroscience to paleoanthropology, and follow - up stories
on a
gene - editing tool, NgAgo, she co-authored with colleagues recently won China's Annual Investigative
Reporting Award in 2017.
The Leopoldina, Germany's national academy of sciences, has published a
report strongly recommending that preimplantation genetic diagnosis of early embryos be allowed by law when couples know they carry
genes that could cause a serious incurable disease if passed
on to their children.
Variants of one
gene had a major effect
on rapid changes in beak size after a drought, researchers
report in the April 22 Science.
He lamented to a graduate student that he had never heard from Prasher; then a search
on a computer database turned up a recent paper by Prasher
reporting the cloning of the synthetic GFP
gene.
A study published June 1 by Nature Communications
reports scientists identify a new
gene essential to this process, shedding new light
on possible new therapeutic strategies.
«This
gene has been
on the agenda for human sex development, but it's quite important that a case has now been
reported.»
A
report in the current issue of the Proceedings of the National Academy of Sciences describes a new method to insert
genes into a mosquito that get passed
on to its offspring.
Based
on their results, Gigi Ebenezer, M.B.B.S., M.D., assistant professor of neurology and the first author
on the study,
reported that protein clumps were detected in 70 percent of cases and 20 percent of patients who carried disease - causing
genes but hadn't yet developed symptoms.
Individuals with one altered
gene had longer telomeres, the caps
on the ends of chromosomes that wear away as we get older, and appeared to be protected against diabetes, the researchers
report.
The process,
reported in Human Reproduction, utilizes DNA fingerprinting (an assessment of active
genes in a given cell) to boost the success rate of IVF and lower the chances of risky multiple births by identifying which of several five - day - old embryos are most likely to result in pregnancy The new method, which will replace unproved alternatives such as choosing embryos based
on their shape, is likely to up the success of women becoming pregnant and lower their chances of having multiple births.
That
report highlighted the UN Convention
on Biodiversity as a potential tool with which to regulate
gene drives, including how, when and even whether they are deployed.
Instead, extra
genes picked up by some pathogens can cause different strains to have wildly different effects
on the immune system, even in the same person, researchers
report January 11 in PLOS Pathogens.
In November 1990, Discover first
reported on efforts by an Australian company called Florigene (then Calgene) to turn roses blue by inserting a pigment - carrying
gene from a bacterium.
The findings
reported in the Cell Press journal Current Biology
on May 8 add to evidence showing just how common and abundant those resistance
genes really are in natural environments.
But help may be
on the way: Scientists
report in next month's issue of Nature Medicine that rats unable to digest lactose, a sugar in dairy foods, are cured by a pill that stitches new
genes into the cells of the gut.
In a
report that appears online in the journal Nature ¸ Dr. Arthur Beaudet, professor of molecular and human genetics at Baylor College of Medicine and a clinical geneticist at Texas Children's Hospital, and colleagues answer the question: «Can we turn
on the activity of the paternal
gene?»
All these differences, suggest biologists Michael Krieger and Kenneth Ross of the University of Georgia, Athens, depend
on which version of a
gene known as Gp - 9 ants possess, the researchers
report in Science online 15 November.
«As a result of the previous study, we
reported that SUMO is probably important for controlling expression of active
genes because we found it
on every
gene we looked at, but only when they were turned
on,» notes Rosonina.
Prof Robin Lovell Badge, Crick Institute,
on the science: «The experiments
reported by Junjiu Huang and colleagues (Liang et al) in the journal Protein Cell
on gene editing in abnormally fertilised human embryos are, I expect, the first of several that we will see this year.
We
report here 13 mutations in the fused in sarcoma / translated in liposarcoma (FUS / TLS)
gene on chromosome 16 that were specific for familial ALS.
«This
report helps shed light
on what can go wrong in individuals with
genes that make one susceptible to autoimmune disease.
Ornish, who has built a reputation
on advocating healthy living, and U.C.S.F. colleagues
report in the journal Proceedings of the National Academy of Sciences USA that they found the activity of more than 500
genes in the normal tissue of 30 men with low - risk prostate cancer changed after the patients began exercising regularly and eating diets heavy in fruit, veggies and whole grain (supplemented with soy, fish oil, the mineral selenium and vitamins C and E) and low in red meat and fats.
They found that the more efficient a mutant was at turning
on genes, the more time it spent flipped into the active shape, they
report in the 23 March issue of Science.
This caused two key
genes normally activated solely
on the left side of the body to be expressed
on the right side, the team
reports in the 4 July issue of Nature.
Clare Wilson
reports research
on the relationship between
genes for proteins that «carry bad cholesterol» and longevity (6 September, p...
In four tumors, the vector mapped to a section of chromosome 12 and turned
on several
genes implicated in cancer, the team
reports tomorrow in Science.
In the current study, the researchers
report that NOTCH1 acts like a sensor
on the endothelial cells — the cells that line the valve and vessels — detecting blood flow outside of the cell and transmitting information to a network of
genes inside the cell.
Now they
report in a study published in PLoS ONE
on February 16 that this
gene interacts with certain types of estrogen and testosterone found in the brain.
They tested their system
on a pair of yeast transcription factors and used the data to predict which yeast
genes the proteins would target, they
report in this week's Science.
Phadnis and colleagues
reported in Science in 2015 that the
gene called Su (Kpn) encodes a checkpoint protein, one that determines whether a cell has completed certain tasks and can go
on to divide.
The
gene, they
reported last March, turns out to be an organizer
gene: it switches other
genes on and off, and in so doing tells cells at the front end of the embryo to become a head.
In separate studies
reported in today's issue of Nature, a team led by geneticist Juan Carlos Ispisúa Belmonte at the Salk Institute in La Jolla, California, and another led by geneticist Cliff Tabin at Harvard Medical School found a very similar
gene in chicks, named Radical fringe (R - fng), that is active
on one side of a budding chick wing.
Its
report,
Gene Drives on the Horizon: Advancing Science, Navigating Uncertainty and Aligning Research with Public Values, stresses that although gene drive offers great promise for agriculture, conservation, and public health, neither the science nor the current regulatory system is adequate to address the risks and requirements of gene drive — altered organi
Gene Drives
on the Horizon: Advancing Science, Navigating Uncertainty and Aligning Research with Public Values, stresses that although
gene drive offers great promise for agriculture, conservation, and public health, neither the science nor the current regulatory system is adequate to address the risks and requirements of gene drive — altered organi
gene drive offers great promise for agriculture, conservation, and public health, neither the science nor the current regulatory system is adequate to address the risks and requirements of
gene drive — altered organi
gene drive — altered organisms.
Based
on this
report, «there is a lot of work that has to happen before we get to the point of releasing a
gene drive [organism] into the environment,» says Todd Kuiken, an environmental scientist with the Wilson Center in Washington, D.C.
He and colleagues
reported last year in PLOS Genetics that they had tracked another speciation
gene that interacts with PRDM9 to a stretch of 4 million DNA bases
on the X chromosome.
Helen Wallace, the director of GeneWatch UK, a biotechnology watchdog group in Buxton, applauds the
report for recognizing that
gene drive technology may have harmful effects
on other species.