Sentences with phrase «represent significant»

Certainly advances in representing topography at a finer scale — putting the mountains in the right place, achieving the right height for the small scale — would represent significant improvements for the small islands.

Since IaIP is an endogenous protein, it would potentially represent a significant advance over other potential therapeutics for DENV.

Points in red represent significant up - regulation after infection, points in blue represent significant down - regulation.

The use of CRISPR in a living mouse and the development of allele - specific approaches represent significant steps forward, but there are several hurdles to overcome before CRISPR - Cas9 could be developed into an HD treatment.

«Our findings represent a significant step toward clarifying the mechanisms that help the body manage the risk of keeping potentially dangerous, but often useful, bacteria around,» says lead study author Dan Littman, MD, PhD, the Helen L. and Martin S. Kimmel Professor of Molecular Immunology in the Department of Pathology at NYU Langone Health.

Through natural selection and the widespread use of antibiotics, however, methicillin - resistant S. aureus (MRSA) strains represent a significant health concern worldwide.

ES derived hepatocyte differentiation on laminins represent significant improvement of metabolic activity and functional organisation

While bone grafts remain the best therapy for non-union bone defects, donor site morbidity and the limited availability of graft material represent significant obstacles for this treatment option [1].

Thus downblending would represent a significant deviation from the existing bilateral agreement complicating negotiations with Moscow.

«The methodologies that RTI pioneered in performing our assessments have broad relevance beyond the State of North Carolina and represent a significant advancement in the science of defining ecological flows,» Dykes said.

Charles Akle, Chairman of Immodulon, said: «The results from this study are remarkable and represent a significant breakthrough in the development of immunotherapy for the treatment of pancreatic cancer.

«Toxins produced by cyanobacteria represent a significant health risk both in water used for consumption and for recreation.

«These new tests are easy to use, are capable of detecting a broad range of pathogens and represent a significant improvement over culture - based diagnostic approaches.

«Most antibiotics have their effect, directly or indirectly, by causing damage to bacterial DNA, so finding ways to cripple DNA repair would represent a significant advance in the treatment of resistant infections,» says senior study author Evgeny Nudler, PhD, the Julie Wilson Anderson Professor of Biochemistry, Department of Biochemistry and Molecular Pharmacology, NYU Langone.

Charles Lieber at Harvard University says the work could represent a significant advance for neural tissue engineering and regenerative neural treatments.

These probably represent a significant food source for the females.

These contributions «represent a significant step forward in structure - function relationships in organic semiconductors, critical for the development of the next generation of flexible electronic devices,» the authors point out.

«These results represent a significant advance in our understanding of how commensal microbes can regulate host intestinal immune responses and suggest that the identification of downstream targets in macrophages and dendritic cells along the GM - CSF axis can help the rationale design of novel strategies for the treatment of IBD patients with defective GM - CSF function,» explained Dr. Merad.

These landslides could potentially cause tsunamis, and represent a significant, and as yet unaccounted for marine hazard.

«Emissions from land use represent a significant piece of the problem and must be addressed if the world is to avoid the worst impacts of climate change,» said Boucher.

The market is so large that any one technology is unlikely to represent a significant share of petroleum.

The findings represent a significant increase in the number of known optical gravitational lenses.

Jeremy Henley, Professor of Molecular Neuroscience in the University's School of Biochemistry in the Faculty of Medical and Veterinary Sciences, said: «These discoveries represent a significant advance and will have far - reaching implications for the understanding of memory, cognition, developmental plasticity and neuronal network formation and stabilisation.

For many individuals affected by the disorder, the elimination of some of the most difficult aspects of the syndrome, such as the insatiable appetite and obesity, would represent a significant improvement in quality of life and the ability to live independently.

Dr. Francis Collins, director of the National Institutes of Health, said the new policy didn't represent a significant shift, since the NIH has continued to assess and fund some gain - of - function experiments even during the moratorium.

«I believe the current state of the protests and the increased City resources required to manage them represent a significant setback.»

He says lowering it to 10 % would represent a significant loss of revenue to the state, as much as three quarters of a billion dollars a year.

The establishment of the Joint Cyber Unit (Reserve) will represent a significant increase in the number of reservists employed in this area of expertise, and we'll work hard to build relationships with employers.

The vote would represent a significant boost for Mr. Barron, who has lagged significantly in both union endorsements and fundraising.

But they currently represent a significant caucus of the population, the support of whom Labour will need to ensure a majority next year.

«These proposals represent a significant softening of the punishment for shoplifting.

«One of our strengths is our good transportation system, and these improvements represent a significant upgrade to the Griffiss International Airport, which is one of our greatest assets for economic development.»

Across the country, and especially among youth, the Greens represent a significant layer of society that recognises the urgency of tackling catastrophic climate change and other ecological threats.

Both bills represent significant improvement on the flawed rules we have in place today, despite the furious efforts of industry lobbyists to shape them to their special interests.

Failed states represent significant security threats to the international community.

UKIP has performed well in recent West Midlands European elections — winning 3 of the 7 regional seats — but the party is unlikely to represent a significant force in Birmingham next month, as their current decline as an electoral force in British politics continues.

Organised by a coalition of academics and civil society organisations under the banner Democracy Matters, Assembly North and Assembly South represent significant interventions in contemporary British politics.

However, these comments represent a significant and positive step.

BHA Faith Schools Campaigner Richy Thompson commented, «These changes represent a significant victory in ensuring Academies and Free Schools have to respect the shared citizenship that all British people enjoy, which includes liberty, equality, tolerance for other views, and respect for the rule of English law.

I concluded that the current commercially - available formulas represent a significant advantage over previous breast milk substitutes, but that they should not have been as widely - adopted as they were during the middle of the 20th century.

If implemented, the proposals represent a significant realignment of the role of the father in childcare.

Vidal will represent a significant addition to Wenger's side as the boss continues his search for world class stars to strengthen his side for a major title challenge next season.

Their stance is irreversible and will represent a significant setback for Jose Mourinho, who had been under the impression a deal to take him to Stamford Bridge was only a matter of time.

Although the Formula E cars represent a significant reduction in speed for Lotterer over his LMP1 career, he's still looking forward to taking on a new challenge.

He only joined Feyenoord in the summer when making a free transfer move but could represent a significant profit if sold in the summer.

Distilled spirits represent another significant focus for the fair with their own dedicated hall in 7a, showcasing nearly 400 exhibitors.

We learned that the cultivation of coffee beans, operation of brewing systems, and use of materials in product packaging all represent significant impacts on the environment.

However, just as it seemed the battle was nearly won, the meat sector — as represented by trade body Meat & Livestock Australia — has mounted what could represent a significant counterpunch, with the announcement that Australia's red meat processors could become carbon - neutral by 2030.

«We have, for some years, held firm to our commitment to sourcing only certified palm oil by 2015, and these changes represent significant progress toward that goal,» said Annette Hansen, director of sustainability for DuPont Nutrition & Health.

Together, they represent significant proportions of global production of key commodities such as soy, pulp and palm oil.