Not exact matches
To make the HSCs, the Harvard group used
human skin cells to create induced pluripotent stem cells (iPSCs),
adult cells researchers genetically
reprogram to an embryonic - stem - cell state, where they can grow into any kind of cell.
A group in Japan hopes to test a similar approach in
humans using stem cells from
reprogrammed adult cells within the next three years.
The idea is that, by placing an
adult cell from a diabetic, for example, into a
human egg cell, the egg cell could turn back the clock of the
adult DNA, or
reprogram it, to its initial, pristine state.
The 2012 platform also repeats previous calls for expanding federal funding «for the stem - cell research that now offers the greatest hope for many afflictions — with
adult stem cells, umbilical cord blood, and cells
reprogrammed into pluripotent stem cells — without the destruction of embryonic
human life.»
In this new study, the scientists mimicked
human tissue formation by starting with stem cells genetically
reprogrammed from
adult skin tissue to form small chambers with beating
human heart cells.
But the favored
reprogramming technique, somatic cell nuclear transfer (SCNT), otherwise known as research cloning, is fraught with ethical pitfalls as well as technical difficulties because it entails creating a
human embryo by inserting an
adult cell nucleus into an ooctye.
Towards the end of the webinar, we will then look at an example of cells present in the
adult human brain that can also be
reprogrammed into neurons; and thus demonstrate, and further open potential therapeutic windows of opportunity.
In this new study, the scientists mimicked
human tissue formation by starting with stem cells genetically
reprogrammed from
adult skin tissue to small chambers with beating
human heart cells.
Scientists in the lab have successfully generated neural stem cells (NCS) from
human embryonic stem cells and
human induced pluripotent stem cells (these are stem cells that have been
reprogrammed from
adult cells).
Induced pluripotent stem cells that were
reprogrammed from normal
adult human tissue.
Having shown that it's possible to directly
reprogram mouse fibroblasts (in a dish and in
adult hearts) and also
human heart fibroblasts in a dish, Dr. Srivastava's group is testing the recipe in pigs, whose heart size and physiology is closer to our own.
However, while hESCs are created from
human embryos, iPS cells are cells that were originally from
adult tissues, such as skin from an
adult body, but have been «
reprogrammed» to a hESC - like state.
The first reports of the successful
reprogramming of
adult human cells back into so - called induced pluripotent stem (iPS) cells, which by all appearances looked and acted liked embryonic stem cells created a media stir.
The first reports of the successful
reprogramming of
adult human cells back into so - called induced pluripotent stem (iPS) cells, which by all appearances looked and acted liked embryonic...
In late 2007, scientists identified conditions that would allow some specialized
adult human cells to be
reprogrammed genetically to assume a stem cell - like state.
Other techniques can
reprogram «
adult» cells in the
human body taken from skin, for example — but the cells still carry baggage from their previous state.
Methods to enhance the
reprogramming efficiency would significantly increase the feasibility of this approach, especially for cell types which tend to be more difficult to
reprogram, such as the primary
adult human fibroblasts used in this study.
The changes to cell
reprogramming that the scientists observed in the young flies can occur inappropriately in
adult human cells — spurring cancer, for example.
Recent studies have demonstrated that some cells from
human adults have the ability to be
reprogrammed to become similar to embryonic stem cells.