Not exact matches
BB: Yes, I got a few questions and one question was asked by Dean, and he asked about whether we have any experience with direct
reprogramming of
keratinocytes to neurons?
Now, of course, that is perhaps valid for if you only test these facts, and Dean asks, actually, whether there will be any other factor combinations that would allow
reprogramming of
keratinocytes?
Apparently,
keratinocytes exhibit a non-permissive chromatin and, hence, can not be
reprogrammed by the BAM combination of factors.
«We checked a whole rainbow of cells and found
keratinocytes to be the easiest to be
reprogrammed,» says Belmonte.
The research, described in the journal Stem Cells under the title «
Reprogramming Postnatal Human Epidermal
Keratinocytes Toward Functional Neural Crest Fates,» was supported by grants from the National Institutes of Health.