To overcome these hurdles, Bhatia and her team
reprogrammed human skin cells into induced pluripotent stem cells (iPSCs)-- embryonic - like stem cells capable of turning into other specific cell types relevant for studying a particular disease.
One week after a breakthrough finding, scientists report they can
reprogram human skin cells to behave like embryonic stem cells without a growth factor known to cause cancer
Scientists can now
reprogram human skin cells to make working cells that resemble «medium spiny neurons», the type of brain cell that is most affected early in Huntington's disease.
We are improving how
we reprogram human skin cells into heart cells, and are investigating the most rapidly evolving areas of the human genome to better understand human disease and evolution.
By
reprogramming human skin cells and other cells from patients with neurologic and psychiatric diseases into induced pluripotent stem cells (iPSCs) and induced neurons (iN), his work seeks to decipher the progression and mechanisms that lead to brain cell dysfunction.
Not exact matches
To make the HSCs, the Harvard group used
human skin cells to create induced pluripotent stem
cells (iPSCs), adult
cells researchers genetically
reprogram to an embryonic - stem -
cell state, where they can grow into any kind of
cell.
Mouse and
human skin cells can be
reprogrammed to hunt down tumors and deliver anticancer therapies.
This year they succeeded in generating mini-livers, or liver buds, from stem
cells that were taken from
human skin and
reprogrammed to an embryonic state.
By
reprogramming skin cells into nerve
cells, researchers at Karolinska Institutet are creating
cell models of the
human brain.
Two groups of researchers report today that washing
human skin cells in similar cocktails of four genes enabled them to
reprogram the
cells to resemble those harvested from embryos.
The
reprogrammed skin cells that have led to this enthusiasm seem to have the same properties as the embryonic stem
cells (ESCs) found in
human embryos just a few days old.
Similarly, the three research teams that last week reported turning mouse
skin cells into embryolike
cells say they will have to study embryonic
cells to learn how to
reprogram human cells in the same way and to understand their potential.
For the new study, the team used a
cell -
reprogramming technique (similar to those used to
reprogram skin cells into stem
cells) to generate
human DRG - type sensory neurons from ordinary
skin cells called fibroblasts.
In this new study, the scientists mimicked
human tissue formation by starting with stem
cells genetically
reprogrammed from adult
skin tissue to form small chambers with beating
human heart
cells.
A new cellular
reprogramming method has been revealed that transforms
human skin cells into liver
cells that are virtually indistinguishable from the
cells that make up native liver tissue.
Skin cells from bonobos (pigmy chimps) were
reprogrammed to pluripotent stem
cells, an advance that allows scientists to study the differences between the neurons of
humans and chimps.
Writing in the latest issue of the journal Nature, researchers in the laboratories of Gladstone Senior Investigator Sheng Ding, PhD, and UCSF Associate Professor Holger Willenbring, MD, PhD, reveal a new cellular
reprogramming method that transforms
human skin cells into liver
cells that are virtually indistinguishable from the
cells that make up native liver tissue.
Using a process called cellular
reprogramming, the researchers take a patient's
skin cells, convert them into so - called induced pluripotent stem (iPS)
cells, which can differentiate into all the
cells within the
human body.
Skin cells reprogrammed to act like embryonic stem
cells — a breakthrough first reported in
human cells 2 weeks ago — are already showing promise as a therapeutic agent.
In this new study, the scientists mimicked
human tissue formation by starting with stem
cells genetically
reprogrammed from adult
skin tissue to small chambers with beating
human heart
cells.
The advantages of this approach began to emerge in 2011, when Dr. Ding announced that he had used his «chemical
reprogramming» method to convert
human skin cells into brain
cells.
However, while hESCs are created from
human embryos, iPS
cells are
cells that were originally from adult tissues, such as
skin from an adult body, but have been «
reprogrammed» to a hESC - like state.
The crux of the discovery, published online Tuesday by the journals
Cell and Science, is a «direct
reprogramming» technique that adds a cocktail of four genetic factors to run - of - the - mill
human skin cells.
While scientists have successfully
reprogrammed different types of mouse
cells (fibroblasts, liver and intestinal
cells),
skin fibroblasts were the only
human cell type they had ever tried their hands on.
Gladstone scientists study how
human skin cells can be
reprogrammed into induced pluripotent stem (iPS)
cells, and they are working to refine the production of these
cells.
Two studies demonstrate the first direct, chemical
reprogramming of mouse and
human skin cells into heart muscle and neural
cells.
A
human heart
cell that was chemically
reprogrammed from a
human skin cell.
Even cooler, scientists are now able to «
reprogram»
human skin cells from patients with neurological disorders and grow them into brain
cells [source: Kavli Foundation].
Other techniques can
reprogram «adult»
cells in the
human body taken from
skin, for example — but the
cells still carry baggage from their previous state.