Sentences with phrase «reprogramming normal genes»

Gore and her colleagues believe these effects are epigenetic; that is, rather than inducing genetic mutations, which would change the sequence of the rats» DNA, the fungicide is permanently silencing or reprogramming normal genes that control development and behavior.

Not exact matches

The researchers demonstrated that blocking the PGD enzyme genetically or with a pharmacologic inhibitor reversed the epigenetic reprogramming and malignant gene expression changes detected in distant metastases, and also strongly inhibited their tumor - forming capacity, with no effect on normal cells or peritoneal pancreatic cancer controls.

By comparing the gene expression patterns of normal beta cells and insulin - producing cells derived from alpha cells, the researchers confirmed nearly complete cellular reprogramming.

Basically, the cells to be reprogrammed are removed from their normal culture system and exposed to the genes (in a gene delivery system), then put back into a new culture system.