In animal models showing that NAD + contributes to longevity, a major factor has been shown to be sufficient availability of the nutrient.46, 50,51 And studies show that when enzymes that
require NAD + are inactive, chromosome structure suffers and cells replicate abnormally.50
This, in turn, would affect adversely the rate of conversion of pregnenolone to progesterone, which
requires NAD +.
Not exact matches
NAD + is
required for activation of enzymes called sirtuins, which are largely credited with the beneficial effects of calorie restriction.
Metabolism of one BHB molecule
require 2 molecules of
NAD + instead of the 4 molecules
required in normal glucose metabolism, thereby preserving the cytoplasmic
NAD + pool (7).
NAD + is
required for our mitochondria to burn glucose to power the basic functions of all our cells, and also plays a key role in signaling with our cells.
Conclusion: Supporting efficient energy production and adequate ATP levels
requires consistent and abundant
NAD +.