Sentences with phrase «require cell growth»

Growth factors are employed in a wide range of clinical applications that require cell growth.

Not exact matches

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

Hydrolyzed Collagen is the missing link in supplying amino acids like glycine, proline and lysine that are required by the body to build connective tissue to regulate cell growth.

Protein helps to rebuild cells and tissue and is required for growth and maintenance.

It will be of no use to invent means for impeding the activities responsible for cancerous growth if the same activities are also required for the survival of normal cells.

«The concentrations of anabasine tested here are 100-fold lower than those required to inhibit growth of parasite cell cultures,» Palmer - Young says, «and we did not find any evidence for variation in anabasine sensitivity across parasite strains.

And while some approaches to regenerating injured tissue require growth factors or biomaterials for the cells to grow on, she noted, the FCSCs grew and matured spontaneously.

They found that normal cells grow faster when in an organoid with cells expressing RasG12V at low levels, but required more than one mutant cell to kick - start this abnormal growth.

The technique, named cell type specific labeling using amino acid precursors (CTAP), exploits the inability of vertebrate cells to synthesize essential amino acids normally required for growth and homeostasis.

In bone marrow transplants, for example, effects of SW033291 in accelerating tissue growth would provide the body the cells required to fight off the two most common and sometimes fatal complications, infection and bleeding.

Transformed liver cells have low iron content, do not replicate hepatitis B virus, and require iron for growth.

For their research, Dr. Klein and his colleagues used fossil data from thousands of extinct rodent species to study the evolution of dental stem cells, which are required for continuous tooth growth.

But because the BMP4 and noggin molecules were directly in contact with the cells, much less growth factor was needed to spur the differentiation — approximately 12 times less than what would be required by conventional solution - based techniques.

Hsp90 inhibitors are among several innovative new types of treatment designed to attack cancer indirectly, by destabilising multiple different proteins required for the growth and survival of cancer cells.

Ralph Brinster, part of the team at the University of Pennsylvania in Philadelphia that first cultured sperm stem cells in the lab, has written that culturing stem cells from human sperm is not far off — humans and mice, like other mammals, he says, require similar growth factors.

A truly multidisciplinary subject, tissue engineering requires the skills of chemists and materials engineers to design and build organ scaffolds, physicists and mathematicians to model tissue growth, and biologists to monitor and control cell growth.

The arsenate - grown cells were analyzed in their resting phase, which requires less phosphate for survival than does active growth, notes Joyce, and cells grown in high concentrations of arsenate did not seem to contain any RNA — possibly because RNA production had shut down to conserve phosphate.

Unlike many other stem cell treatments, such as heart patches, the procedure Taylor and his colleagues used did not require any advance culturing or growth in the lab.

«The CDK4 and 6 proteins are critical drivers of the cell - division cycle and are required for the formation and growth of various types of solid tumors,» says Dana - Farber's Shom Goel, MD, PhD, co-first author of the study with Molly DeCristo of the Hematology Division at BWH.

While human cord blood represents a potentially important source of hematopoietic stem and progenitor cells (HSPC), current two dimensional (2D) growth conditions employed to amplify cell numbers to the level required for many regenerative applications lead to a decline in the absolute percentage of the most primitive HSPCs [1].

Through its various targets, MMP1 promotes not only tumor invasion but also breast cancer colonization to bone by mechanisms that include the release of membrane - bound EGF - like growth factors from tumor cells, leading to activation of EGF receptor signaling and suppression of OPG expression in osteoblasts, which in turn promotes the differentiation and activation of osteoclasts required for bone destruction and enhanced tumor growth in the bone microenvironment (32).

STAT5 activation is required for interleukin -9-dependent growth and transformation of lymphoid cells

This project, which could take several years, involves completely describing the cell lines, their growth characteristics, the conditions they require to grow robustly, which genes are turned on or off, and so on.

The emergence of multicellular animals from single - celled ancestors over 600 million years ago required the evolution of mechanisms for coordinating cell division, growth, specialization, adhesion and death.

Further studies showed that Notch1 knockdown in NSCLC helps induce cell death (which inhibits tumor initiation and growth); this process is mediated by p53, and thus the effects of inhibiting Notch1 require functional p53.

Suppression of Growth by All - trans Retinoic Acid Requires Prolonged Induction of Interferon Regulatory Factor 1 in Cervical Squamous Carcinoma (SiHa) Cells

Hydrolyzed Collagen is the missing link in supplying amino acids like glycine, proline and lysine that are required by the body to build connective tissue to regulate cell growth.

1) Phytonutrients: * Occur naturally in fruits and vegetables * Promote the function of the immune system * Help fight off viruses as well as reduce inflammation * Associated with the treatment and / or prevention of cancer and cardiovascular disease 2) Enzymes: * Responsible for metabolic processes that occur within a cell and are necessary for sustaining life * Assist and play a large role in digestion, energy production, blood coagulation and contraction of muscles 3) Amino Acids: * The basic building blocks of protein * Absorption of amino acids is essential for your metabolism 4) Essential Fatty Acids: * Reduce the risk of heart disease and some forms of cancer * Improve mood * Decrease inflammation 5) Vitamins: * Essential for the normal growth and development of all human beings * Healthy maintenance of cell tissues and organs * Help process proteins, carbohydrates and fats required for utilization 6 & 7) Macro and Trace Minerals: * Involved in electrolyte balance of body fluids * Essential for normal cellular activity * Provide hardness to bones and teeth

Piceatannol in essence inhibits the pathways required for maturation and growth of immature fat cells.

Our gut lining is one of the most active sites of cell production and growth, which requires a good supply of natural Vitamin A. Poor digestion causes Vitamin A deficiency, and gut disease is a symptom of Vitamin A deficiency, so this is a sort of «chicken and egg» relationship.

Every day, your body requires a certain amount of energy to perform basic functions, such as muscle movement, cell growth, and energy conversion.

Oranges are also rich in vitamin A, which is required for normal growth and cell differentiation.

With regard to food for vegan bodybuilding, additional physical effort in the form of strength or endurance training mandates an increase in the daily amount of protein required for recovery and regeneration including the additional growth of muscle cells.

Healthy hair growth requires effective cell activity, including cell division in the hair follicle.

Studies show that nitric oxide signaling and the blood flow increases it stimulates play a central role in nerve cell maintenance, growth and repair.,, Most pertinent to anyone looking to enhance their aptitude for learning, nitric oxide - induced blood flow also makes forming new memories physically possible as it plays a key role in what neurologists call long - term potentiation, a process required for assembling and reinforcing new synaptic connections throughout the entire cerebral cortex, striatum, and hippocampus.

Copper is required for hemoglobin production in red blood cells, production and function of white blood cells, the absorption, transport and use of iron, energy metabolism, the development, growth and maintenance of bone and connective tissue, the formation and maintenance of myelin sheath (outer surface of nerve fibers), adrenal hormone production, thyroid hormone production, muscle tone, immunity, reproduction, tissue repair, pigmentation of hair and skin, and proper growth and development of infants and children.

Pomegranate juice contains folic acid — this is important to note because during times of rapid cell growth and division, the body requires more folic acid in order to keep the body healthy and protect it from developing certain medical conditions.

* OptiZinc ®, a patented form of zinc, is a trace mineral required for numerous vital cell functions, including growth and development as well as sexual health.

It's required for skin cell and muscle growth though, and one role is in stimulating collagen production.

Within the prostate, testosterone is converted to dihydrotestosterone, which is then absorbed by the cell nuclei to activate genes required for cell growth.

Omega 3 and omega 6 fatty acids are required for normal growth and functioning of the cells, muscles, nerves, and organs.