Sentences with phrase «require large numbers»

Generally, its almost impossible for more than one person to keep a secret and so conspiracies that require large numbers of people are generally prima facia nonsense.

In exchange, the developers are able to iron out any bugs and glitches and, most importantly, any issues with multiplayer servers which require large numbers of players, all online at once, to be accurately tested (as an increasing number of high profile developers are finding out to their chagrin).

«We used these methods because more traditional approaches require large numbers of specimens,» said Brian N. Popp, University of Hawai'i at Mānoa Professor of Geology and Geophysics in the School of Ocean and Earth Science and Technology.

The Thorough QT clinical assessment also has its limitations, as those studies are done in humans and typically require large numbers of patients.

Psychiatric diseases, since they are the result of a complex mix of genetics, environment, and behavioral factors, require large numbers of people, or what's known as a large sample size.

By contrast, a structure with high information content requires a large number of instructions.

I typically stay away from recipes that require a large number of ingredients, but I always love making my guacamole salad recipe because I get to chop away for awhile!

«Another weak explanation, this time proffered by the president himself, is that the economy is in such a dire situation that requires this large number of ministers to accomplish the task of putting it back on track.

Making useful computations requires large numbers of qubits and it is this upscaling to large numbers that is providing a challenge worldwide.

Given that a small proportion of the population is homosexual, prospective studies require a large number of children.

Using conventional methods is hard since they require a large number of repeated measurements.

Conventional methods require a large number of repeated measurements on the qubits for reliable verification.

Exhaustive contact tracing requires large numbers of staff, and is challenging both in dense urban areas and in remote regions that are difficult to reach.

This is not easy, however, as it requires a large number of immune cells and a lot of mice need to be bred as donors.

Traditional epidemiology requires large numbers of subjects to identify broad effects, such as the link between urban life and mental illness.

And even if it is technically feasible, cloning requires large numbers of human eggs, which are in very short supply.

SCNT requires a large number of eggs and produces very few stem cell lines.

Abstract: Some of the new quantum technologies ranging from extremely precise sensors to universal quantum computers require a large number of quantum bits in order to exploit the advantages of quantum physics.

Running at maximal speed triggers a rapid increase in breathing and heart rate and requires a large number of muscles.

As advertising revenues are modest compared to dues, free dating sites require a large number of page views to achieve profitability.

Evidently those newsletters are partly responsible for the current trend of authors paying for reviews (reportedly, they require a large number of 4 and 5 star reviews on Amazon in order to accept a book for promotion.

Earlier space projection technologies have required a large number of distinct components and are relatively large systems requiring substantial space to install.

This study required a large number of dogs to participate for their entire life - time anl provided the framework for future investigations into heart disease in our breed.

Due to their massive structure, male Newfoundland dogs can easily get to 60 - 70 pounds and require a large number of calories per day.

This shouldn't be surprising since herding requires a large number of problem - solving skills combined with the ability to listen to and obey the handler.

However, those didn't require a large number of points / miles and were shorter trips.

Some people have their eyes on a piece of merchandise or a service that requires a large number of rewards, but they don't spend enough on the card to realistically accumulate enough points or cash back to redeem for it.

Qantas and Korean Air also partner with Emirates, but making a first class Emirates booking requires a large number of miles plus expensive taxes and fees.

Incompatible with Virtual Console and WiiWare titles that require a large number of inputs.

Both works entail impressive, time - consuming work and require a large number of people.

Consequently, development in the 1002 Area would require a large number of small production sites spread over a large region, and connected by an infrastructure of roads, pipelines, power plants, processing facilities, loading docks, dormatories, airstrips, gravel pits, utility lines and landfills.

It takes a lot of time and it requires a large number of posts to really take off.

Managing a business requires a large number of skills that most lawyers haven't worked on developing.

In 2011, when the B.C. Supreme Court certified the class action in Logan v. Dermatech, her counsel proposed notice be provided by a direct mailing to those who had been injected with Dermalive, and sought an order requiring a large number of physicians in Canada who may have injected patients with Dermalive to provide her counsel with those patients» names, addresses, and other contact information.

Because backsplashes don't require a large number of tiles, you can splurge on fancy ones, add a mix of high - end and plain ones, or create a focal point with mosaics, mirror tiles or other decorative options.

Not exact matches

By choosing to include the number of donors and the amounts of some of its larger donations, including one of $ 10.1 million in the first year and another of $ 10.1 million in the last seven months of 2011, the group was somewhat more transparent than the IRS requires.

Pricing: Varies based on number of contact records; $ 1395 / mo for up to 10k records with standard plan; $ 2995 / mo for up to 10k with advanced plan; consultation required for larger enterprise solutions.

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

With the number of female founders on the rise, it is no longer uncommon to publicly discuss the challenges of raising capital while visibly pregnant, how long one can put off starting a family, or what constitutes an appropriate maternity leave plan for businesses that are not large enough to require adherence to the Family and Medical Leave Act (FMLA).

A number of operational features were required to implement such an overnight reverse repo, or ON RRP, facility: It would need same - day settlement; 16 the operation would need to be run predictably, every day, and as late in the day as possible, to give lenders time to bargain with other counterparties using the outside option of investing with the Federal Reserve; 17 an appropriate spread below IOR would be required to ensure that the facility neither induced large changes in the structure of money markets nor lost the ability to support interest rate control; 18 and the operations would need enough unused capacity that lenders could credibly propose to leave borrowers that did not offer an adequate interest rate.19

The «model» behind our largest investment required nothing more than sixth grade math, and a napkin — not a sophisticated spreadsheet capable of more numbers than I'm capable of counting.»

For the number to return to $ 11 million quickly, he said, would probably require a large financial bubble.

A number of issues were discussed including the impact of the proposed amendments to the Yukon Environmental and Socio - economic Assessment Board Act, which is currently before Parliament and which will among other things, remove set timelines for assessments as well as requiring re-assessments for large scale mining projects, where a full environmental screening has already been positively concluded.

As such, Monarques could eliminate the extremely large capital outlay required to build a mill as it could potentially ship the Wasamac ore to any of a number of possible custom milling opportunities in the vicinity of Wasamac (see map of potential sites).

Although this can increase a company's bottom line, it can also require putting large numbers of domestic workers out of work, which can be hazardous to the company's global brand management.

Without getting too bogged down in the technical details, mining Ether requires a computer to continuously run a cryptographic hash function, which is a way to reduce an arbitrarily large amount of data (in this case a block on the Ethereum blockchain) to a datum of a fixed size (a string of so many numbers and letters).

They're the two largest exporters of crude oil and, as you can see above, Russia requires an oil price north of $ 100, Saudi Arabia right at about $ 95 per barrel on a Brent basis, and we're below that number now.

There are hundreds of billions of stars in our galaxy, each with planets, that large of a number even if a tiny fraction had an atmosphere and even if a fraction of them had water (as we know it is required, but life may not require it on other planets) it would be amazing if there wasn't a carbon based lifeform somewhere else in our galaxy, let alone in the universe with billions of galaxies each with billions of stars and trillions of planets.

Politically conservative Christianity requires very selective reading of the Bible emphasizing a small number of out of context points and ignoring large swaths that are inconvenient.

He helps show that a variety of forms of imagination is required to bridge the chasm opened up by Plato between the sensible and the intelligible, a bridging that must take into account a large number of fundamental polar contrasts involved in the contrast of physical - mental?