Not exact matches
Psychiatric diseases, since they are the result
of a complex mix
of genetics, environment, and behavioral factors,
require large numbers of people, or what's known as a
large sample size.
«Lowering the cost will open the way for new applications, especially ones that
require testing a
large number of samples.»
Because many
of the genes influencing facial morphology are likely to have small effects, successfully mapping a
large number of these genes will
require much greater
sample sizes and a more comprehensive approach to quantifying facial features
of interest.»
Due to the
large sample numbers required for statistical power and the limited budget, we couldn't sequence all
of them.
Running as facility
of this size
requires a massive amount
of support and we work closely with the library preparation team that supplies
large numbers of DNA templates in a from ready to be sequenced, the Institute's IT team that maintains the extensive amount
of compute and storage infrastructure necessary, sequencing informatics which develops software tools to process, analyse, store and track all the data, projects and
samples for the Illumina pipeline and the development team which invents novel and improved protocols to take better advantage
of this new technology.
The law
of large numbers requires, by definition, independent
samples as input.
Large sample depth during other periods is not then
required (a robust curve to remove growth trend is already in hand) except in relation to the general coherence
of the tree response to the environmental parameter
of interest — if the trees are «noisy» then a
larger number of samples will be
required to extract signal than if the signal is more coherent.
With regard to the
sample size
required for valid application
of this modeling approach, we are hesitant to speak
of sufficient
sample sizes, since a
large number of observations with little score variation over time (as in our second empirical application) does not necessarily provide richer information than a smaller
sample with more fluctuations.