Sentences with phrase «required rates of decrease»

Not exact matches

Further evidence of the decline can be seen in the decreasing rates of first - time patents since the 1980s, as well as increases in demand for professional licensing, which could further restrict new business opportunities by requiring expensive (and often unnecessary) credentials.

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

It has created a long - term target of significantly decreasing the multiple birth rate from IVF, and it requires each clinic to develop an annual plan to meet this goal.

Surprisingly, higher use of reminders did not decrease the rate of events requiring medical attention.

Together, these observations demonstrate that blood - forming stem cells require a highly regulated rate of protein synthesis, such that increases or decreases in that rate impair stem cell function.

In the most commonly sold supplement form, BCAAs require no digestion and are quite rapidly absorbed into the bloodstream — which is really neat because it means BCAAs can be used as an immediate energy source during your training sessions, and they will quickly act to decreasing the rate of protein breakdown.

However, the faster update rate of the electrophoretic display media, which is required, results in a much higher power requirement than usual as well as a decrease in the display lifetime.

As a result, a discount rate that is higher is required which in turn decreases the pricing of the bond.

To the extent currency exchange transactions do not fully protect a Fund against adverse changes in currency exchange rates, decreases in the value of currencies of the foreign countries in which a Fund will invest relative to the U.S. dollar will result in a corresponding decrease in the U.S. dollar value of a Fund's assets denominated in those currencies (and possibly a corresponding increase in the amount of securities required to be liquidated to meet distribution requirements).

Healthy animals can combat long periods of starvation through decreased metabolic rate, but animals that are sick or injured require more energy, which increases metabolism.

The required supplies (BOX 3) are minimal in cost — $ 0.26 per patient — but offer the ability to further decrease the use of inhalant agents and the maintenance fluid rate, thereby preventing use of hypotensive treatments and further reducing the clinic's overhead cost.

And even with strong international climate policies, more rapid decarbonization (the rate of decrease in emissions per unit of GDP) will require higher costs and major policy change.

Since you are trying to match the past and the rate of warming is decreasing it requires that your models run cool at earlier times.

Two days earlier EPA announced final regulations (which I call the Skyrocketing Rates Power Plan or SRPP, but which EPA calls the «Clean Power Plan» or CPP for obvious reasons) requiring states to decrease CO2 emissions from electricity production and use primarily by increasing the capacity of non-hydro «remewable» (wind and solar) sources of electric power from 4 percent to 28 percent by 2030.

According to analysis from Project Catalyst hitting this goal requires a 17 gigaton decrease in annual greenhouse gas emissions to 44 gigatons per year from the projected increase of global emissions of 61 gigatons by 2020 if we continue polluting at current rates (Figure 1).

Budget 2015 proposes to decrease the required annual minimum withdrawals so they are more in line with long - term investment returns and expected rates of inflation.

Few prevention programs have been rigorously evaluated, and only a few have proven effective.60, 61 Health - care based prevention programs, including parent education programs to reduce rates of abusive head trauma, and improving physician ambulatory care practices to help families decrease risk factors for child maltreatment have shown good initial results, but require further evaluation.62, 63 Specific intensive home visitation programs such as nurse home visiting programs for first - time mothers have proven to be both clinically and cost effective in preventing maltreatment.64, 65 However, a program of nurse home visitation has been found ineffective as a treatment model for abusive and neglectful families, highlighting the importance of primary prevention, as well as the need to rigorously evaluate potential treatments for abusive families.66 Child welfare services are historically structured as short - term interventions that monitor families for recidivism, provide parenting education and assist with referrals to community - based services.

Once again as your conversion rates increase, the amount of leads you will require to reach your goal will decrease.