One of the most promising avenues for developing a cure, however, is through gene therapy, and to create those therapies
requires animal models of disease that closely replicate the human condition.
There are currently no
disease - modifying treatments that have been shown to slow the progression or delay the onset
of HD in humans; however, several compounds have demonstrated promise in
animal models of HD.1 Robust and sensitive markers
of disease progression are
required to assess their efficacy in humans.