Sentences with phrase «requires knowing your targets»

Like the personal trainer, this requires knowing your targets and establishing a rapport.

Not exact matches

Sticking to a prescribed format, requiring that the updates be concise and on target and knowing when to move a discussion outside of the regular meeting is important to making sure the meetings maintain effectiveness.

For instance, an initiative known as «should - cost» has effectively driven down the high price of many programs by requiring managers to determine what a given program or piece of a program should cost and then set targets for fitting the program into its cost paradigm.

We regularly welcome inbound delegations exploring targeted opportunities that require the kind of skilled workforce and exceptional quality of life Washington state is known for.

But that kind of targeted tracking would not require broad access to records of people unconnected to terror suspects and their known associates, which is hinted at by both Sen. Udall's remarks and the high rate of modifications imposed on Section 215 orders by the FISA court.

Should monetary policy drop its inflation target and instead do whatever it takes to maintain a stable growth path for nominal GDP, no matter what that requires it do, no matter what fiscal policy is?

After a positive shock to the price level, knowing that the central bank has a price - level target, agents fully anticipate the disinflation required to return the price level to target.

No matter the industry you belong to, the truth is that the market is dynamic and it requires consistent brand awareness and brand boosting cum promotion to continue to appeal to your target market.

As for our shots on target, even when you are 1 v 1 with the goalie a final bit of technique is still required to get the goal, Sanchez knows all about it and Welbeck needs to hone that skill, shooting directly at the goalies body will not get you the goal.

When the scientists blocked Treg cells from accumulating in the fat by targeting a molecule that the immune cells require, mice no longer developed type 4 diabetes in old age.

These subtypes are known to predict differential responses to emerging targeted therapies, but they are cumbersome to measure accurately and require biopsies.

«Our findings are important because knowing the location and specific cell type that require Jagged expression gives us the information we need to target therapeutics to the right place to compensate for the lack of Jagged function in Alagille syndrome,» says Dong.

To examine the functional role of Smad1 and Smad5 in GDF5 - induced neurite length, primary cultures were transfected by microporation with siRNAs targeting the co-Smad4 (required for nuclear translocation of Smad1 / 5 transcriptional complex [33]-RRB- or the Smad1 and Smad5 effectors proteins, which are known targets of miR - 181a (Table 2).

Abbreviations: Aβ, amyloid β - peptide; AD, Alzheimer's disease; ALS, amyotrophic lateral sclerosis; Ambra1, activating molecule in Beclin -1-regulated autophagy; AMPK, AMP - activated protein kinase; APP, amyloid precursor protein; AR, androgen receptor; Atg, autophagy - related; AV, autophagic vacuole; Bcl, B - cell lymphoma; BH3, Bcl - 2 homology 3; CaMKKβ, Ca2 + - dependent protein kinase kinase β; CHMP2B, charged multivesicular body protein 2B; CMA, chaperone - mediated autophagy; 2 ′ 5 ′ ddA, 2 ′, 5 ′ - dideoxyadenosine; deptor, DEP - domain containing mTOR - interacting protein; DRPLA, dentatorubral pallidoluysian atrophy; 4E - BP1, translation initiation factor 4E - binding protein - 1; Epac, exchange protein directly activated by cAMP; ER, endoplasmic reticulum; ERK1 / 2, extracellular - signal - regulated kinase 1/2; ESCRT, endosomal sorting complex required for transport; FAD, familial AD; FDA, U.S. Food and Drug Administration; FIP200, focal adhesion kinase family - interacting protein of 200 kDa; FoxO3, forkhead box O3; FTD, frontotemporal dementia; FTD3, FTD linked to chromosome 3; GAP, GTPase - activating protein; GR, guanidine retinoid; GSK3, glycogen synthase kinase 3; HD, Huntington's disease; hiPSC, human induced pluripotent stem cell; hVps, mammalian vacuolar protein sorting homologue; IKK, inhibitor of nuclear factor κB kinase; IMPase, inositol monophosphatase; IP3R, Ins (1,4,5) P3 receptor; I1R, imidazoline - 1 receptor; JNK1, c - Jun N - terminal kinase 1; LC3, light chain 3; LD, Lafora disease; L - NAME, NG - nitro - L - arginine methyl ester; LRRK2, leucine - rich repeat kinase 2; MIPS, myo - inositol -1-phosphate synthase; mLST8, mammalian lethal with SEC13 protein 8; MND, motor neuron disease; mTOR, mammalian target of rapamycin; mTORC, mTOR complex; MVB, multivesicular body; NAC, N - acetylcysteine; NBR1, neighbour of BRCA1 gene 1; NOS, nitric oxide synthase; p70S6K, ribosomal protein S6 kinase - 1; PD, Parkinson's disease; PDK1, phosphoinositide - dependent kinase 1; PE, phosphatidylethanolamine; PI3K, phosphoinositide 3 - kinase; PI3KC1a, class Ia PI3K; PI3KC3, class III PI3K; PI3KK, PI3K - related protein kinase; PINK1, PTEN - induced kinase 1; PKA, protein kinase A; PLC, phospholipase C; polyQ, polyglutamine; PS, presenilin; PTEN, phosphatase and tensin homologue deleted from chromosome 10; Rag, Ras - related GTP - binding protein; raptor, regulatory - associated protein of mTOR; Rheb, Ras homologue enriched in brain; rictor, rapamycin - insensitive companion of mTOR; SBMA, spinobulbar muscular atrophy; SCA, spinocerebellar ataxia; SLC, solute carrier; SMER, small - molecule enhancer of rapamycin; SMIR, small - molecule inhibitor of rapamycin; SNARE, N - ethylmaleimide - sensitive factor - attachment protein receptor; SOD1, copper / zinc superoxide dismutase 1; TFEB, transcription factor EB; TOR, target of rapamycin; TSC, tuberous sclerosis complex; ULK1, UNC -51-like kinase 1; UVRAG, UV irradiation resistance - associated gene; VAMP, vesicle - associated membrane protein; v - ATPase, vacuolar H + - ATPase; Vps, vacuolar protein sorting

So choice is most definitely a core theme in Dishonored, it does require some imagination to find different paths but finding a path and getting to your target without any NPC knowing your there is a definite rush.

The other two phases, as said, are the use of these clues and materials found on the scene to access better and more complex solutions in the dialogue, and then the dialogue itself where you are required to save the target no matter what, with multiple endings which determine whether you'll sacrifice yourself, for example, or throw the both of you from the building.

But knowing the general demographics of neighborhoods or recruiting students and faculty in a targeted fashion would seem to require some systematic, individual typing by race.

Under the federal No Child Left Behind Act, schools that receive funding from the federal Title I program for disadvantaged students are required to offer supplemental education services if they fail to meet their achievement targets for three or more years.

The law requires that targets for percentages of students scoring above that mark, known as proficiency rates, rise annually until meeting about 100 percent proficiency in 2014.

When a student can apply the target skills in multiple settings on a regular basis and at grade level performance then s / he no longer requires intervention.

U.S. Sen. Tom Harkin, D - Iowa, the chairman of the Senate education committee, is set to unveil a bill to reauthorize the No Child Left Behind Act that would require states to set achievement and growth targets for students, including subgroup students.

They are activities that directly address critical content, target specific standards, and require thoughtful products that allow students to show what they know.

Thanks to Odysseyware, we know the «holes» in each student's math knowledge and can provide targeted instruction to ensure he or she masters required concepts.

We know that schools are required to conduct a needs assessment if they are identified under ESSA for comprehensive or targeted support.

A collective response will be required to ensure that all students learn, so teacher teams would work collaboratively to define each essential standard; deconstruct the standard into discrete learning targets (determine what each student must be able to know and do to demonstrate proficiency); identify the prior skills needed to master the standard; consider how to assess students on each target; and create a scope and sequence for the learning targets that would govern their pacing.

With Ice Cream Sandwich one of the things that we did in order to enable more consistency and more ease of developer portability, was it was required that from Ice Cream Sandwich onwards, the core widgets and framework themes were always included, so that developers can target them and have their application look, feel, and work more consistently no matter what skin has been put on it.

The main difference between those is that the target date fund really only requires you to know your expected retirement date and let the rest of it work for you, you just pick the plan or the fund that works for that date.

• Activist value investing, by its very nature, requires a thorough understanding of target firms, since you have to know where each of these firms is failing and how you would fix these problems.

Dec. 7, 1:12 a.m. Updated Robert Collier posted a piece on the disagreement between Joe Romm and me over the mix of deployment of known technology and basic inquiry and development of new technology required if targets for greenhouse gases like those of California are to be seen as more than wishful thinking.

Fergus Ewing, Scotland's Energy Minister, says, «We know there is doubt and scepticism about our 100 per cent renewables target, and the financial and engineering challenges required to meet it.

Mitigation scenarios (also known as climate intervention or climate policy scenarios) are defined in the TAR (Morita et al., 2001), as scenarios that «(1) include explicit policies and / or measures, the primary goal of which is to reduce GHG emissions (e.g., carbon taxes) and / or (2) mention no climate policies and / or measures, but assume temporal changes in GHG emission sources or drivers required to achieve particular climate targets (e.g., GHG emission levels, GHG concentration levels, radiative forcing levels, temperature increase or sea level rise limits).»

Lastly, the Court refuted the argument that the territorial limitation was no longer necessary, as Sweden had already fulfilled its requirements relating to those targets, because the schemes establish a certain investor confidence within Sweden in relation to green electricity production: «[a] ccordingly, the effectiveness of such a scheme requires by definition a measure of continuity sufficient, in particular, to ensure the fulfilment of the legitimate expectations of investors who have committed themselves to such projects, and the continued operation of those installations» (paras 100 - 103).

Using Boolean search requires the case team to know exactly what language was used in the target documents ahead of time.

Once you reach the target years or age, premiums are no longer required but the policy's benefits lasts the insured's entire life.

Use the calculator available in this article, to know approx required savings to reach your target amount.

Even for a well - known and reputable brand like Telegram, however, reaching a target goal $ 2bn for an ICO is no easy feat, requiring big - money crypto investors to hop on board — but many are passing on the opportunity.

Evaluate — Once you've identified organizations of interest, you'll need to know what's important to hiring managers in your target companies, such as the skills and knowlegde they require.

This may require a bit of soul searching but it's important that you know your story as it pertains to your target & the hiring manager's goals if you are going to convince anyone you can do the job regardless of the career path less taken.

Finding the right job will require you to know how to write a targeted cover letter and how to match your qualifications to a job.

If you don't have a great deal of time to spend on training and you know your target employer does not require an advanced degree, this program might make sense for your future.

Either track you choose allows you to pursue national certification, but it is important to know what your target employer requires, how much time you reasonably have to spend, and your plans for future education.

It is important to know if your target employer requires one type of degree over another when choosing between these two.

We therefore require the individual to have: A proven track record in selling to the public in a business to business environment either in person or by telephone Experience of working to financial targets and KPI's Proficiency to a very high standard in English and Maths A Full clean UK manual driving licence (minimum 12 months) We want a person who is hungry and can motivate themselves to deliver their best on a daily basis no matter what the days throws at them.

It is important, in consideration of the financial resources required for assessment and treatment of CD / ODD, to know what factors are more strongly associated with the development of CD / ODD, as Frick and Loney [26] and Smith and Farrington [64] have suggested that targeting the factors contributing to the development of CD and ODD is most effective in the planning and implementation of treatment.

No longer will targeted parents be required to prove «parental alienation» in Court.

Lawrence Scheinert, director of the Office of Special Measures at the U.S. Treasury Department's Financial Crimes Enforcement Network (FinCEN), presented a new program called the Geographic Targeting Order during the REALTORS ® Legislative Meetings & Trade Expo in Washington, D.C.. It's a temporary anti-money laundering program requiring U.S. title insurance companies to report information about «covered transactions» made by what's commonly known as shell companies, Scheinert said at the Business Issues Policy Committee meeting.