Sentences with phrase «requires large applications»

There has been considerable controversy over the construction of this course, as some environmentalists believe that a golf course — which typically requires large applications of fertilizer and pesticides — could pose a danger, though run - off, to the ecologies of the barrier reef and sea.

Not exact matches

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

Traditional Lenders tend to have a long application process, require significant paperwork, do personal credit based evaluation, only lend large amounts, and require specific high - value collateral.

For instance, LiftFund, one of the larger microlenders, accepts applications from startups and requires no minimum personal credit score from business owners.

Here is the bottom line as far as I can see: IF you are self - employed when filing for early retirement, and *** if, on your application, you are asked how many hours you work *** (and I would like to hear from anybody here who has actually filed for benefits before their Full Retirement Age) and IF you work more than the allowable hours to be considered «retired» (again, I believe it's no more than 45 for most people but no more than 15 if you work at an occupation requiring a «specific skill» or own a large business),

To the extent permitted by law, we will disclose your information to government authorities or third parties if: (a) required to do so by law, or in response to a subpoena or court order; (b) we believe in our sole discretion that disclosure is reasonably necessary to protect against fraud, to protect the property or other rights of us or other users, third parties or the public at large; or (c) we believe that you have abused the Sites or the Applications by using them to attack other systems or to gain unauthorized access to any other system, to engage in spamming or otherwise to violate applicable laws.

For applications where higher capacities are required, the new OHAUS Defender 3000 series offers models ranging from 60 lb up to 600 lb in capacity, great for receiving and larger volume weighing.

The larger organelles, such as the nucleus and vacuoles, are easily visible with moderate magnification (although sometimes a clear view requires the application of chemicals that selectively stain parts of the cells); they were among the first biological discoveries made after the invention of the microscope.

«Lowering the cost will open the way for new applications, especially ones that require testing a large number of samples.»

In addition, a large number of scientific societies sponsor fellows; those also require separate applications.

But many applications of these machines require large arrays of rock - hard moving parts, which would be difficult to build with typical biological structures.

«Although some aspects of normal state spin electronics, or spintronics, are more efficient than standard semiconductor electronics, the large - scale application has been prevented because the large charge currents required to generate spin currents waste too much energy,» said Professor Mark Blamire of Cambridge's Department of Materials Science and Metallurgy, who led the research.

Additionally, installation of electrolyzer systems on electrical grids for power - to - gas applications, which integrate renewable energy, grid services and energy storage will require large - capacity, cost - effective hydrogen storage.

The transmission of high quantities of data by radio over large distances serves a high number of important application areas: the next generation of satellite communication requires an ever - increasing data offload from earth observation satellites down to earth.

Such large - scale modeling and simulation requires the heft of a supercomputer, and for this effort the team used Blue Waters at the National Center for Supercomputing Applications at the U. of I.

Future researchers could apply this technique to efficiently deliver large repair templates for applications that require large gene fusions.

Rant is excited the electrically powered origami lever has proven to be suited for continuous operation and believes «The big nanolever opens fascinating perspectives for advanced sensing applications, not only in the design of sensor surfaces with multiple different ligands, but also when size, shape, and conformation information is required for large targets».

for applications that require the large genetic capacity of a lentiviral vector but for which transient transgene expression is sufficient.

Researchers have also developed integrase - deficient lentiviral vectors for applications that require the large genetic capacity of a lentiviral vector but for which transient transgene expression is sufficient.

Summary: Gibbsite (α - Al (OH) 3) is an important natural and industrial material that is used in a wide variety of energy applications, and is a significant component of some of the high - level nuclear waste stored in large quantities at the Hanford Site, Washington, U.S.A., and at the Savannah River Site, South Carolina, U.S.A. Industrial - scale processing of these materials requires an understanding of their behavior in highly alkaline solutions (often called Bayer liquors); processing of slurries and precipitates from these liquors is facilitated by controlling the nanoparticulate gibbsite morphology.

Schools regularly use large amounts of data from media rich applications and web ‑ based services, requiring higher levels of security and network performance than most homes and many businesses.

A ground - breaking shared school application for the nation's fourth - largest city required a robust marketing and communications effort.

With two speeds available, the alternator can match the output of a larger and more expensive single - speed alternator, and it also has the potential of replacing, again at much lower cost, two or more alternators that are often required for heavy - duty vehicle applications.

For small schools with less resources and large schools that receive hundreds, if not thousands, of applications, the resources required to read every essay from every applicant may outweigh the benefits of the extra information gained from the admission essay.

Traditional Lenders tend to have a long application process, require significant paperwork, do personal credit based evaluation, only lend large amounts, and require specific high - value collateral.

Federal law requires that fee harvester companies prominently display their large fees on the credit card application.

Cons: Not recommended for kittens under eight weeks of age, not recommended for cats under five pounds, larger cats may require a higher dose, some cats have had a bad reaction, some of the product may wash off if the cat bathes within 24 hours of application

Larger and more aggressive / energetic dog breeds require heavy - duty materials (we recommend 8 gauge welded wire mesh for such applications).

Please note that 10 business days is the minimum amount of time required for processing most permit applications, and applications for large or complex activities may take longer.

This services provides email and internet usage; however, our satellite - based bandwidth is limited and we are NOT able to support Skype or other VOIP protocols, instant messenger services, Youtube, video downloads, webcam, streaming video, IP TV, IP based mobile phones or other applications that require large amounts of bandwidth.

But AbEx works in particular — with their intense color, large scale, and, in Pollock's case at least, frenzied application of paint — can elicit an emotional response from viewers that requires a physical, often prolonged, encounter with them.

The parameterization is intended for application in large - scale atmospheric and cloud models that can predict 1) the supersaturation of water vapor, which requires a representation of vertical velocity on the cloud scale, and 2) concentrations of a variety of insoluble aerosol species.

Applications with large heat losses require high performance of heating sources.

It is very popular for use with concrete in floor heating systems, swimming pool heating, or any other application where large quantities of hot water are required.

It has become clear that staying «well below 2C» will require the large - scale application of CDR.

The first listing of a Korean company, with 31 main subsidiaries outside the country, entailed a large amount of due diligence work and complex regulatory issues, which not only required deep knowledge of Korean securities law, but also skillful and creative applications and good sense of international business operations.

Core public authorities, such as BCC, which is the country's largest local authority, require a degree of clarity and precision in the application of s 6 (3)(b) if their valuable relations with the private sector are to be maintained.

Environmental Impact Assessments (EIAs), which are required in large - scale planning applications, are supposed to ensure that planning decisions take into consideration the environmental effects of any significant development.

Because of the technical nature of the work, some of the larger employers require at least a 2.1 degree in any field before making an application.

Many of the larger employers require graduate candidates to have, or be on track for, a 2.1, but a good number will also accept 2.2 s. Smaller employers will have a straightforward recruitment process, often comprising an application and an interview or two; larger employers will follow a more complicated process, including online aptitude tests as well as an online application, a telephone interview (or, rarely, a video interview) and an assessment day.

Analyzing a large amount of data encompasses the use of computer software applications that require a moderate level of information technology expertise, and the best vocational programs in North America train students to use these programs.

Now most large companies require a total automated application process, so that they can manage the resumes, applicant's qualifications and documents the best possible.

Key responsibilities will include: Networking and building relationships with clients and candidates Developing key business relationships with new clients, generating client meetings and new job opportunities Candidate attraction, using for example - job boards and social media Lead generation and conversion Managing opportunities, placing candidates and fee negotiation Interviewing candidates and matching candidates to vacancies Using negotiation and objection handling skills to maximise revenue Providing professional and consultative advice to clients and candidates Skills Required Resilience, strong listening and application skills with the ability to learn quickly Career minded, hard working and driven Confident with the ability to build rapport Ability to nurture relationships Benefits Fast moving and performance - orientated business with excellent rewards Very competitive salary and benefits package Fantastic opportunities for career progression to Senior Consultant, Principle Consultant or Managing Consultant Industry - leading training Sunday Times Best 100 companies to work for «Investors in People (IIP)- Platinum» company Guidance and support from a Manager with over 20 years experience A great place to work Search is one of the UK's largest recruitment companies with 13 locations nationwide covering over 20 industry sectors.

With regard to the sample size required for valid application of this modeling approach, we are hesitant to speak of sufficient sample sizes, since a large number of observations with little score variation over time (as in our second empirical application) does not necessarily provide richer information than a smaller sample with more fluctuations.

Health & Safety Code § § 1596.70 et seq., requires that notice of the proposed use only be mailed or delivered to all real property owners «within a 100 - foot radius of the exterior boundaries of the proposed large family day care home» no less than 10 days prior to the date on which the zoning application decision will be made.