mTOR is found in virtually all multi-cellular organisms and indeed, many single celled organisms like yeast (where much of
the research on autophagy is done).
VIDEO — Dr. Yoshinori Ohsumi at the Tokyo Institute, who has received the 2016 Nobel Price on
his research on Autophagy The report starts 3 min into the video
The 2016 Nobel prize for medicine was awarded to Japanese scientist Dr. Yoshinori Ohsumi for
his research on autophagy, a process that occurs during fasting.
Not exact matches
The ultimate goal of Dr Janji's
research team is to provide the proof of concept that targeting
autophagy could improve the efficacy of current immunotherapies, notably those based
on immune checkpoint blockades.
The
research group focused
on the precise role of chloroplast - targeted
autophagy in the plant survival strategy under low - energy stress.
This year's Nobel Prize in Physiology or Medicine has been awarded to Yoshinori Ohsumi, a cell biologist at the Tokyo Institute of Technology's Frontier
Research Center, for his work
on autophagy, the process in which cells degrade and recycle cellular components.
The studies
on autophagy by Yoshinori Ohsumi, which earned him the Nobel Prize in Medicine in 2016, and the discovery of cell cycle regulatory genes for which Leland Hartwell, Timothy Hunt and Paul Nurse received the same award in 2001, including the
research of Elizabeth Blackburn, Carol Greider and Jack Szostak
on telomeres, telomerase and its protective effect
on the chromosomes, were all made possible thanks to yeast.
The year Ohsumi and Tsukuda published their yeast screen, only a couple of dozen
research papers were published
on autophagy.
She completed her PhD investigating HPV - encoded proteins in oncogenesis with Dr Lawrence Banks at ICGEB Trieste, Italy, and postdoctoral
research on the molecular biology of
autophagy at Memorial Sloan Kettering Cancer Centre in New York.
It was once again an «uncool» area of
research, yet Cuervo went
on to make groundbreaking discoveries in the field, including alterations in lysosomal protein degradation that are associated with neurodegenerative diseases, and the ways that
autophagy protects against aging.
His
research shows that the greatest biological processes —
autophagy, bad cells and cell parts regenerated, production of stem cells, etc. — are achieved
on a longer fast than intermittent fasting achieves.
Stress resistance has not been assessed however and so the biological relevance of this finding is currently unknown.32 Several IER trials (75 - 85 % ER
on restricted days) in overweight / obese populations have reported reductions in various markers of oxidative stress 37, 41, which in one study was accompanied by a complementary increase in the anti-oxidant uric acid.37 In a direct comparison of IER (75 % ER for two days / week) and CER, both ER strategies displayed equal efficacy in reducing levels of fast - acting advanced oxidation protein products (AOPP) after six months, which displayed a tendency to occur earlier (i.e. at three months) in the IER group.41 Levels of slow - acting (i.e. long term) AOPP tended to decrease in the IER group and increase in the CER group which the authors proposed may have resulted from IER - induced activation of autophagy, a key homeostatic cellular process in which dysfunctional or unnecessary cellular proteins are degraded and recycled.41 On the other hand, a follow - up study using similar IER / CER protocols demonstrated comparable reductions in AOPP in both groups after three months.48 Summary and Future Research Directio
on restricted days) in overweight / obese populations have reported reductions in various markers of oxidative stress 37, 41, which in one study was accompanied by a complementary increase in the anti-oxidant uric acid.37 In a direct comparison of IER (75 % ER for two days / week) and CER, both ER strategies displayed equal efficacy in reducing levels of fast - acting advanced oxidation protein products (AOPP) after six months, which displayed a tendency to occur earlier (i.e. at three months) in the IER group.41 Levels of slow - acting (i.e. long term) AOPP tended to decrease in the IER group and increase in the CER group which the authors proposed may have resulted from IER - induced activation of
autophagy, a key homeostatic cellular process in which dysfunctional or unnecessary cellular proteins are degraded and recycled.41
On the other hand, a follow - up study using similar IER / CER protocols demonstrated comparable reductions in AOPP in both groups after three months.48 Summary and Future Research Directio
On the other hand, a follow - up study using similar IER / CER protocols demonstrated comparable reductions in AOPP in both groups after three months.48 Summary and Future
Research Directions
Is there any
research on whether
autophagy has positive effects for those with auto immune diseases?
More information about scientific
research on Fasting and
Autophagy (healing and self cleansing of the human body promoted by Fasting)
The
research clearly shows that practicing Eat Stop Eat kicks
Autophagy into overdrive so you naturally turn
on your cleansing and detoxifying pathways.