Sentences with phrase «research on bone marrow»

Since panosteitis is a disease of the fatty bone marrow in the long leg bones of the adolescent or young adult dog, it may be that research on bone marrow will lead to an understanding of the etiology and hence the best treatments, cure, and prevention of the disease.

Not exact matches

Wagers was inspired to research bone marrow stem cells and did her postdoctoral work on adult stem cells.

The main treatment is still bone marrow transplantation: a risky procedure that relies on finding a suitable donor, explains Patrick Aubourg, a neurologist at France's INSERM research institute.

«Proper blood cell production is dependent on functioning hematopoietic stem and progenitor cells that are destroyed during conditioning procedures for transplantation or following bone marrow injury,» said the study's first author Kevin A. Goncalves, who performed this research as part of his PhD studies in cellular and molecular physiology at the Sackler School.

Most research has focused on understanding and managing the late consequences of sepsis while little is known about the changes occurring in the bone marrow at early stages of the response to bacterial infection, when the opportunity for effective treatment might still be available.

Prior research with cultured tissue had shown that a mix of chemicals could change bone marrow stem cells from mice to those resembling brain cells, but when a team led by neurologist Lorraine Iacovitti of Thomas Jefferson University in Philadelphia tried the same brew on human cells, the number altered was modest.

Case Western Reserve research associate Amar Desai, PhD, worked between the Markowitz and Gerson laboratories to determine the effect of SW033291 on mice that had received lethal doses of radiation and then received a partial bone marrow transplant.

Basic research has centered on identifying and characterizing hematopoietic stem cells, however, it is still not clear how hematopoietic stem cells actually work, and how they are regulated because of the complexity of the bone marrow microenvironment.

Research conducted at Japan's National Institute for Materials Science built on previous findings that gold nanoparticles can encourage stem cells in the bone marrow to differentiate into bone cells, and that specific biomolecules can inhibit or promote stem cell differentiation.

Previously Dr. Martini worked at Shire plc in Lexington, Mass., as Senior Director of Discovery Biology and Translational Research, Mass., focusing on fibrotic diseases of muscle, kidney, skin, lung, bone marrow and metabolic liver diseases, with particular emphasis on different therapeutic modalities for pathway modulation.

Dr. Al - Homsi's research is focused on preventing GvHD, a potentially life - threatening complication of bone marrow transplantation.

Background In our institute, the first research program on disseminated tumor cells (DTC) detection in the bone marrow of early breast cancer patients was initiated in the late 90's; with about a thousand patients included, we constituted one of the largest cohort ever reported and contributed to the landmark report that established bone marrow DTC as a level - of - evidence 1 prognostic factor in early breast cancer (Braun, N Engl J Med 2005).

Quyyumi says the research team checked whether patients» pre-existing levels of CD34 + cells in their bone marrow had a significant effect on their outcomes; they did not.

Another is to monitor the effects of transplanting telomerase - deficient but ex vivo telomere - extended bone marrow into late - generation, TMM - disabled mice, so as to be certain that the niche of such animals (or, by implication, aging humans) will support the homing, engraftment, and initial development and differentiation of such cells; the necessary research is underway now thanks to a SENS Foundation grant to Dr. Zhenyu Ju of the Institute of Laboratory Animal Sciences and Max - Planck - Partner - Group on Stem Cell Aging in the Chinese Academy of Medical Sciences, and research partner of prominent telomere biologist Dr. K. Lenhard Rudolph.

Further research on this zebrafish FA model will lead to a deeper understanding of the molecular basis of bone marrow failure in FA and the cellular role of RAD51.

The published research on Regenexx procedures accounts for approx. 50 % of the world's orthopedic stem cell literature (cumulative n of patients published & treated with bone marrow stem cells as of 7/1/2017)

Their research focused on evaluating the safety and efficacy of autologous bone marrow - derived stem cell transplantation in individuals with type 2 diabetes with good glycemic control as well, which emerged as an important aspect in the transplantation group as well as in the non-transplanted group.

London About Blog We are Anthony Nolan and we save the lives of people with blood cancer who need a stem cell (or bone marrow) transplant.Read incredible transplant patient stories, hear from stem cell donors, catch up on medical research, and pick up tips from runners, cyclists and fundraisers.