Less than two months into his presidency, Obama announced that he would reverse the Bush policies by allowing
research on cell lines created after the Bush ban.
The President declared that federal funds could be used to support
research on cell lines that were already in existence on that date.
On March 9, 2009, President Obama lifted the ban that had previously restricted the use of federal funds for embryonic stem cell
research on cell lines that had been created after August 9, 2001.
In accordance with that decision, the new guidelines would allow scientists to use NIH funds for
research on cell lines isolated from embryos as long as the cells were derived by privately funded researchers who followed a set of ethical guidelines.
If the president's philosophy — to restrict federal funding to
research on cell lines created prior to August 9, 2001 — lacks a principled moral basis that amplifies the view that the governmental obstacles imposed on stem cell research, and the delays they have caused, themselves represent an ethical problem.
Not exact matches
In all likelihood, soon after he is sworn in, federal dollars will start flowing toward
research on new embryonic stem -
cell lines, bringing with it new battles to fight.
In August of last year, President Bush approved the use of federal funds to support
research on a limited number of existing human embryonic stem
cell lines.
Jose E. Garcia - Arraras, a biology professor at the university's biology
research center
on the Río Piedras campus, said a power plant designed to keep scientific samples refrigerated broke down and the roof of a critical building gave way to flooding, rendering «samples, libraries,
cell lines, etc. lost.»
The year's most prominent science issue, federal support of embryonic stem
cell research, is so controversial that the sons of Ronald Reagan gave dueling speeches at the opposing party conventions; Michael Reagan backs President George W. Bush's policies, including the ban
on funding for
research on new stem
cell lines, while Ron supports Senator John Kerry's promise to lift restrictions.
Congressional supporters of stem
cell research have re-introduced legislation to codify President Barack Obama's 2009 executive order lifting restrictions
on the number of human embryonic stem
cell lines available to federally funded researchers.
Another problem is that in its July 2009 Guidelines
on Human Stem
Cell Research, NIH spelled out specific requirements about embryo donation for newly derived lines, says Pilar Ossorio, a legal scholar who studies research ethics at the University of Wisconsin Law
Research, NIH spelled out specific requirements about embryo donation for newly derived
lines, says Pilar Ossorio, a legal scholar who studies
research ethics at the University of Wisconsin Law
research ethics at the University of Wisconsin Law School.
In yesterday's order, Lamberth wrote that they did not: «The prior [Bush Administration] guidelines, of course, allowed
research only
on existing stem
cell lines, foreclosing additional destruction of embryos.»
But just how close adult and reprogrammed stem
cells can come to matching the capabilities of embryonic stem
cells has become a contentious question in the debate over whether the federal government should continue funding
research on embryonic
lines.
Research based
on such false
cell lines would undermine the understanding of different cancers and possible treatments, and clutter the scientific literature with bogus conclusions.
She sees all these
lines of
research converging
on the notion that a strong
cell - mediated response gives people the best chance of defeating HIV.
In its comment
on the draft policy, the the International Society for Stem
Cell Research asks NIH to define some «core principles» covering what is ethically acceptable rather than set explicit rules that might exclude «
lines that have been in routine use for the past ten years.»
UPDATE: NIH posted a notice today saying that ongoing
research on previously approved stem
cell lines can continue.
The final guidelines
on research with human embryonic stem
cells issued
on Monday by the National Institutes of Health set out criteria for determining which ES
cell lines can be used in federally funded experiments and give NIH discretion to approve old
lines that don't meet stringent modern ethical requirements.
The bill was put forth to loosen the restrictions Bush placed
on human embryonic stem
cell research on August 9, 2001, when he banned federal funding for work with any stem
cell line created after that date.
While conservatives in Congress took turns echoing George W. Bush's opposition to destroying human embryos for
research, Lensch's colleague Paul Lerou stepped into a small room behind a heavy black curtain to check up
on a
line of nonpresidential embryonic stem
cells.
Previously scientists had to rely
on cancerous
cell lines to carry out such
research, but the mutated genomes of these
cells obscure early changes, which can be observed in still healthy
cells.
The
research team was also able to shed more light
on the role of Paneth
cells — a type of
cell found in the epithelial
lining of the small intestine.
Tensions have escalated since August 2001, when President George W. Bush limited publicly funded
research on embryonic stem
cells to already existing
lines.
Cells from her malignancy were cultured and used to start a
cell line, called HeLa, which lives
on to this day in
research labs around the world.
Roein - Peikar also noted that their experiments are mainly based
on Chinese Ovary Hamster
cells, a
cell line derived from the ovary of the Chinese hamster, often used in biological and medical
research.
However, it is notoriously difficult to maintain the integrity of
cell lines — due to contamination or simple mistakes such as mislabeling, later generations of a
cell line may bear no resemblance to the original sample, potentially invalidating results of
research performed
on mistaken
cells.
On 9 August, President George W. Bush announced that federal funding of stem cell research is permitted, but only for that on cell lines already established from embryos discarded by fertility clinics by the time of his statemen
On 9 August, President George W. Bush announced that federal funding of stem
cell research is permitted, but only for that
on cell lines already established from embryos discarded by fertility clinics by the time of his statemen
on cell lines already established from embryos discarded by fertility clinics by the time of his statement.
On 11 March, the European Molecular Biology Laboratory (EMBL) issued a press release proudly announcing that a
research team there had deciphered much of the genetic sequence of one of the most widely used
cell lines in cancer studies and had made the information available publicly.
«I am excited to embark
on this
line of
research and look forward to the day when patient - specific stem
cells are utilized to treat people suffering from debilitating injuries and health conditions.»
For while the new NIH guidelines explicitly permit funding for
research on stem
cell lines in which human embryos have already been destroyed, they also explicitly forbid funding for
research on stem
cell lines that have been produced by SCNT (see section V. part B).
His executive order allowed funding
on embryonic stem -
cell lines derived from embryos that had already been destroyed, but excluded funding of
research using stem
cells from embryos destroyed after August 9, 2001 (the date of his announced policy).
June 21, 2007: Bush vetoes another DeGette - sponsored bill that would allow
research on all stem -
cell lines using
cells created for in - vitro fertilization and scheduled to be discarded.
My
research interests as Ohio Eminent Scholar focused
on developing methods for isolating and characterizing extracellular vesicles derived from both
cell lines and patient samples, including the specific profiling of microRNA encapsulated in these vesicles.
In the next decade, molecular
research is going to further develop along five
lines: predictive medicine, that investigates the genetic conditions predisposing to tumor risk; early molecular diagnosis; the evaluation of each patient's prognosis based
on his / her genetic profile, in other words, the analysis of what kind of mutation affects the DNA of altered
cells; the investigation of the individual response to drugs, based
on our genetic knowledge; «smart drugs», molecules able to hit the target in a selective way, killing only the deprogrammed
cells.»
I continue this
line of
research as such, and I currently am the principal investigator
on multiple projects involving translational studies involving
cell or gene therapy -.
(20) It was this emerging
line of
research that van Deursen's collaborator Dr. James Kirkland presented at the fifth annual Strategies for Engineered Negligible Senescence Conference (SENS5) in September of this year, (18) and it was his expertise in the senescence of adipose tissue that he contributed to the new report
on the effects of ablating such
cells.
AÂ Emory News item
on a helpful part of the microbiome focuses
on how the same type of bacteria â $ «lactobacilli â $ «activates the same ancient signaling pathway in intestinal
cells in both insects and mammals. It continues a
line of
research from Rheinallt Jones and Andrew Neish
on how beneficial bacteria stimulate wound healing by activating ROS (reactive oxygen species).
STEM
CELL HOUSE — A bill lifting restrictions on a certain type of embryonic stem cell research cleared a House committee Monday on a party - line v
CELL HOUSE — A bill lifting restrictions
on a certain type of embryonic stem
cell research cleared a House committee Monday on a party - line v
cell research cleared a House committee Monday
on a party -
line vote.
The bottom
line, says Daley, is that
research on both types of stem
cells must continue, because it's too early to predict where the safest and most effective
cell - based therapies will come from.
In an executive order, Bush stated that federal funds could only be used for
research on human embryonic stem
cell lines that had already been established (only 22
cell lines).
In a 2001 executive order, Bush limited federal funding of embryonic stem -
cell research to work
on lines already in existence.
Thus, all
research on lines of human embryonic stem
cells as the
cells of various phenotypes derived from these
lines should aim to lexploration mechanisms or the development and validation of therapeutic applicable to serious diseases.
The legislation would lift Bush's restriction that limits federal
research on embryonic stem -
cell lines to those created before August 2001.
In a new study, scientists led by Selvi C. Jeyaraj of the
Research Institute at Nationwide Children's Hospital have identified a biological mechanism that may be responsible for icy extremities: an interaction between a series of molecules and receptors
on smooth muscle
cells that
line the skin's tiny blood vessels.
Since 2001, the United States has banned federal funding for
research on all but a few
lines of embryonic
cells.
That bill, based
on one from Rep. Diana DeGette, D - Colo., would have allowed federal dollars to flow toward
research on stem
cell lines using embryos left over from in vitro fertilization, slated for disposal and donated by the parents.
And then our newest
line of
research is relevant to
cells in the spinal cord, so I'm especially excited to come to Gladstone and find new collaborators to work with
on that project.
His wife, Nancy, has called for the Administration to make more stem
cell lines available for federally funded
research on diseases like Alzheimer's and Parkinson's.
Newer
lines of
research are focused
on understanding cancer stem (CSC)
cell biology so that therapies targeting them can be developed.
Current policy only allows federal monies to be used for
research on 21 stem
cell lines that existed before 2001.