Clinical
Research Trials show significant benefits with tapping that improve over time (compared to high weight regain rates for diets).
Not exact matches
A stroke drug invented at The Scripps
Research Institute has
shown signs of safety and efficacy in a mid-stage clinical
trial.
In a March 16
research note, Andrew Fein, an analyst at H.C. Wainwright & Co., reported that OvaScience (OVAS: NASDAQ) shifted its focus back to
research and development, after interim data from the first 20 patients in its Phase 1
trial of OvaPrime
showed no signs of efficacy despite indicating safety and tolerability.
But it is important to note that the Tufts study wasn't a safety
trial, because existing
research was already available that
showed that beta - carotene in Golden Rice was as safe as beta - carotene in other foods.
While this is not really a surprise, since similar
research and
trials with wounds on people has
shown the healing benefits of using medical grade manuka honey, this is the first time a clinical
trial has been done on horses.
Research studies in Europe and the United States of America (on farm and pilot
trials) on the effects of farming systems on beneficial invertebrates and birds consistently
shows a better performance of the organic system.
Many
research trials have
shown that BCAA's improve red blood cell count, hemoglobin, hematocrit, serum albumin, fasting glucose levels, increased glycogenesis and rapid improvement in muscular inflammation (2, 3, 4).
Research evidence from three randomised - control
trials in the USA
show positive effects from pregnancy through to the time children were 15 years old.
Research shows that families typically receive roughly half of the number of home visits expected.16, 17 For example, across three randomized controlled
trials conducted of Nurse Family Partnership, average dosage of visits ranged from 45 to 62 percent.18
Research also
shows that many, perhaps most, families enrolled in home visiting programs drop out before their eligibility ends.16, 19,20 Some home visiting studies have varied the dosage that families were offered and found that fewer home visits produced outcomes similar to higher levels of exposure.21
Recent
research of home birth data has
shown a higher risk in home VBAC for mothers who have never had a prior vaginal birth, yet access to
trial of labor in level 1 and level 2 hospitals is lacking.
The protective effects of breast feeding have been
shown to be dose responsive16 17 18 and minimal breast feeding may not be protective.17 Researchers in lactation have advocated that
research on promotion of breast feeding must target exclusive breast feeding, 19 and ours is one of the larger randomised controlled
trials with this primary outcome.
The review of three
trials, involving 233 women, found there has not been enough
research done to
show the effects of castor oil on ripening the cervix or inducing labour or compare it to other methods of induction.
While the reform alliance provided data
showing trial lawyers» campaign contributions were tops among influence blocs, the New York Public Interest
Research Group put teacher unions far in the lead in combined lobbying and campaign donations.
The ongoing
trials could have major consequences even without yielding a cure:
research has
shown that an intervention that could delay the onset of Alzheimer's by just 2 years would result, 50 years later, in nearly 2 million fewer cases of the disease in the United States than projected otherwise.
A clinical
trial conducted by researchers at the Virginia G. Piper Cancer Center Clinical
Trials, a partnership between Scottsdale Healthcare and the Translational Genomics
Research Institute (TGen),
showed that a new drug called MM - 398, given in combination with 5 - flourouracil (5FU) and leucovorin, produced a significant overall survival rate in patients with advanced, previously - treated pancreatic cancer.
Previous
research raised the possibility that HDL might not be quite as protective against heart disease as generally believed by cardiologists, especially after several clinical
trials of HDL - raising drugs
showed little or no effect.
The team's samples of 2672 papers, published between 1992 and 2011,
showed that all four of these measures have yet to be adopted widely in animal
research, though they are now standard practice in clinical
trials.
«Our study
shows the significant impact of adding carotid plaque measurement using vascular ultrasound and coronary calcium scoring with CT scan to our conventional assessment for cardiovascular disease,» says Roxana Mehran, MD, the study's co-lead author and Director of Interventional Cardiovascular
Research and Clinical
Trials at the Zena and Michael A. Weiner Cardiovascular Institute at Mount Sinai Heart at Icahn School of Medicine at Mount Sinai.
«Our review of the literature
showed several positive
trial results, but we also found important
research limitations in the studies, indicating a need for higher quality, more definitive
trials on antidepressant use for postsurgical pain.»
The probes targeted to breast cancer have
shown great promise so far in breast cancer clinical
trials, and Mankoff and his Penn Medicine colleagues have helped lead this
research effort.
The case
shows that even when carried out at mainstream hospitals, experimental stem cell therapies can have unpredictable consequences, says Alexey Bersenev, a stem cell
research analyst who blogs at Cell
Trials.
An affordable hepatitis C combination treatment including the new drug candidate ravidasvir has been
shown to be safe and effective, with extremely high cure rates for patients, including hard - to - treat cases, according to interim results from the Phase II / III STORM - C - 1
trial presented by the non-profit
research and development organisation Drugs for Neglected Diseases initiative (DNDi) at the International Liver Conference in Paris.
However, what our
trial has
shown is that although this is still the case, the proportion of women who will actually have a recurrence without radiotherapy is very small (less than 5 percent), five years after treatment,» said Ian Kunkler, F.R.C.R., professor of clinical oncology at the Edinburgh Cancer
Research Center in the University of Edinburgh.
The authors point to studies of harmful and beneficial effects of thrombolytic and antiarrhythmic drugs for myocardial infarction, for example: «Not only would systematic reviews... have reduced waste resulting from unjustified
research, they would also have
shown how to reduce morbidity and sometimes mortality, both in patients allocated to relatively less effective or actually harmful treatments in unnecessary
trials, and in patients generally,» the authors write.
Commenting on the study, Dr Andres Poveda, Head of the Gynecological Oncology Clinic at Fundación Instituto Valenciano de Oncología, Valencia, Spain, who was not involved in the
research, said the CIRCCa study is the second recent
trial to
show the benefit of adding an antiangiogenic drug to chemotherapy in cervical cancer.
But the latest
trial, led by geriatrics expert Richard Weindruch at the Wisconsin National Primate
Research Center and published in Science, is the first to
show that caloric restriction can improve survival in primates.
«Taking a break from dieting may improve weight loss:
Research showed in a randomized controlled
trial, that taking a 2 - week break during dieting may improve weight loss.»
This clinical
trial is the culmination of long - standing
research led by Professor John Greenwood at the UCL Institute of Ophthalmology
showing the potential therapeutic benefits of using statins to treat autoimmune diseases such as multiple sclerosis and uveitis.
Reanalysis of the World Health Organization's Antenatal Care
Trial (WHOACT)
shows that there is an increased risk of fetal death at between 32 and 36 weeks for women who have a reduced antenatal care package, finds
research published in BioMed Central's open access journal Reproductive Health.
Despite lowering low - density lipoprotein (LDL), known as «bad» cholesterol, while markedly increasing levels of high - density lipoprotein (HDL), or «good» cholesterol, a large clinical
trial to investigate the cholesterol drug evacetrapib was discontinued early after a preliminary analysis
showed it did not reduce rates of major adverse cardiovascular events, according to
research presented at the American College of Cardiology's 65th Annual Scientific Session.
A large randomized controlled
trial of ischemic postconditioning in patients who had experienced the deadliest form of heart attack — ST - segment elevation myocardial infarction (STEMI)-- failed to
show that this procedure significantly reduces death from any cause or hospitalization for heart failure, according to
research presented at the American College of Cardiology's 65th Annual Scientific Session.
This
research is part of the Pulmonary Nodule Plasma Proteomic Classifier (PANOPTIC) study, a clinical
trial of 685 patients 40 years old or older, with newly discovered lung nodules 8 to 30 millimeters in diameter as
shown on a recent (fewer than 60 days old) CT scan.
«Epilepsy drug discovered in fish model
shows promise in small pediatric clinical
trial:
Research suggests zebrafish models may be efficient resource for identifying drugs for clinical use.»
Nelson Michael of the U.S. Military HIV
Research Program, which helped run the
trial, is more optimistic: «We've
shown that this 26 - year global effort has not been in vain.»
«The current
trial showed an absolute survival benefit of almost 10 percentage points, eclipsing any effect of drug intervention,» wrote Dr. Joglar, who holds the Elizabeth Thaxton and Ellis Batten Page Professorship in Cardiac Electrophysiology
Research.
The
research spanned 10 years and its efficacy was
shown in mice and in 20 type 1 diabetes patients who took part in a clinical
trial at the Barbara Davis Center for Childhood Diabetes at the University of Colorado School of Medicine.
On average (top), a
research participant might seem to produce a sustained, elevated rhythm of beta, but a look
trial by
trial (lower rows)
shows that beta emerges in discrete bursts.
Research, early stage testing, and clinical
trials are
showing extremely positive results for this new kind of medicine.
The
trials would be for proof of concept, to
show whether researchers can, for the first time in humans, stimulate the right B cells to start the process of making broadly neutralizing antibodies, long considered the «holy grail» of HIV vaccine
research because they defend against infection by a broad spectrum of HIV strains.
«This finding is consistent with a hypothesis generated out of the follow - up studies to the RV144 HIV vaccine
trial in Thailand that
showed the first efficacy in humans,» noted COL Nelson Michael, Director of the U.S. Military HIV
Research Program at the Walter Reed Army Institute of
Research.
Currently the
research team is conducting a randomized, double - blind placebo - controlled
trial of this system, which aims to
show whether the closed loop system can prevent hypoglycemia.
In addition to
researching advancements to improve heart function, MSI - 1346 has already
shown positive results in clinical
trial patients with obesity and type - 2 diabetes.
Glenda Gray, executive director of the Wits Health Consortium's perinatal HIV
research unit in South Africa, presented data today at the HIV R4P conference in Cape Town indicating that the prime - boost vaccine candidates initially tested in the RV144
trial in Thailand — the only HIV vaccine
trial to date to
show any efficacy — induced cross-clade immune responses in a Phase I safety
trial conducted in South Africa, with immunogenicity similar to or greater than that of the responses induced in Thai volunteers.
«There are no clinical
research trials to say whether it works or not and in pregnancy you don't want to do any interventions that have not
shown to be safe and effective,» Donnica Moore, MD, ob - gyn and president of Sapphire Women's Health Group in New Jersey, tells Health.
Reviews of clinical
trials on hypnosis have concluded that the evidence of its effectiveness for smoking cessation is insufficient, but other
research shows promise: The preliminary results from a small 2007 study of smokers hospitalized with cardiopulmonary diseases
showed that the patients who chose to participate in a hypnotherapy session were more likely to be nonsmokers six months later than patients who chose nicotinereplacement therapy (NRT) alone.
Terry: Because I'm also a researcher and I write grants, get funding, do clinical
trials, and every year, we have 2
research days, one for the Department of Medicine and one for the College of Medicine, where my lab presents our data, and so my colleagues have seen the progress with other progressive MS folks and the remarkable results that we are
showing.
PS is the most
researched, scientifically validated brain health nutrient,
shown effective in numerous clinical
trials to improve brain focus, memory and cognition, plus alleviating stress and improving mood.
Another
trial in Biochemical and Biophysical
Research Communications
showed that it improves digestion.
Research on men in different occupations has
shown how those occupations where their a real contest going on, or hard physical work, such as the military,
trial lawyers, and construction workers experience higher testosterone levels than men in more sedate occupations.
(49, 50) In a review of six other clinical
trials of patients with depression taking oral curcumin supplements for 4 to 6 weeks,
research shows that curcumin helps reduce depressive symptoms and feelings of anxiety with no adverse effects.