Sentences with phrase «researchers altered the gene»

The MU researchers altered the gene to enable more efficient transfer of the nNOS gene to mouse hearts.

In others, the researchers altered a gene that regulates phospholipids, the primary type of fat in cell membranes, which spurred the cells into producing more cholesterol on their own.

Not exact matches

Researchers in England have found that in trace amounts, they activate estrogen receptors in cells, which in turn alters the activity of certain genes.

Using Atlantic killifish (Fundulus heteroclitus), the researchers examined whether mitochondrial - nuclear interactions alter the frequency of alternative forms of a gene that arise by mutation, called alleles, for over 11,000 nuclear DNA sequence variations within a population of the fish with mixed ancestry.

Nearly five years after the gene - editing tool debuted, researchers for the first time have used it to alter genes in viable human embryos.

If researchers do prove that testosterone can alter human sexual orientation — gay gene or no gay gene — the possibility of preventing homosexuality will become a reality.

In the new study, the researchers sequenced the entire genome of mice that had undergone CRISPR gene editing in the team's previous study and looked for all mutations, including those that only altered a single nucleotide.

More and more, researchers are finding that an extra bit of a vitamin, a brief exposure to a toxin, even an added dose of mothering can tweak the epigenome — and thereby alter the software of our genes — in ways that affect an individual's body and brain for life.

CRISPR - Cas9 is a versatile and highly accurate gene - editing technology that allows researchers to modify specific parts of an organism's genome by altering sections of the DNA sequence.

We're funding researchers to investigate how drugs alter what genes are activated such that they modify the function of the cells, and how this, in turn, modifies the functions of brain circuits, and how that modifies behavior.

Researchers at the University of Exeter and UCL (University College London) have identified a gene which can be used to predict how susceptible a young person is to the mind - altering effects of smoking cannabis.

Because the prion - forming protein identified in the study normally functions as a regulator of gene activity, the researchers say their discovery raises the possibility that when it switches to a prion state, it could alter genetic expression and bacterial behavior.

Individuals with one altered gene had longer telomeres, the caps on the ends of chromosomes that wear away as we get older, and appeared to be protected against diabetes, the researchers report.

In a paper last August, researchers reported that the virus (Zaire ebolavirus) was altering its genes almost twice as fast as it had during previous Ebola outbreaks in Central Africa (SN: 9/20/14, p. 7).

In their study, the researchers showed that already at the age of six weeks in the mice with a rapid weight gain, the DPP4 gene was less methylated at four specific loci, i.e. epigenetically altered, compared to the other mice.

With their new fruit fly research model, the UNC researchers altered the histone gene so that this particular enzyme could not modify its histone protein target.

The brain - size - altering effect of the gene is what led the researchers to study the impact on IQ.

The researchers discovered that this receptor mutation profoundly altered gene expression in neurons receiving dopamine at distal sites in the brain, specifically in the prefrontal cortex.

The researchers are not yet sure how this happens; the mutated gene may alter the production of the pigment, melanin, they report online today in Current Biology.

The researchers are continuing their work to gain more insights into the genes altered by this dysfunctional dopamine signaling.

Fragile X mental retardation protein, or FMRP, oversees a set of genes that alter how DNA is packaged, researchers report September 7, 2017 in the journal Cell.

The researchers further found that miR - 486 is itself regulated by the tumor - suppressor gene p53, the most frequently altered gene in human cancers, and that activity of miR - 486 is partially dependent upon functional p53.

In a study to be presented on Feb. 5 at the Society for Maternal - Fetal Medicine's annual meeting, The Pregnancy Meeting ™, in Atlanta, researchers will present findings from a study titled, Maternal Diet Alters the Breast Milk Microbiome and Microbial Gene Content.

Based on a list of about 30 disease - related DNA targets that researchers are interested in altering through gene editing, the researchers made a second list of nearly 3,000 guide RNAs (gRNAs).

Years of diabetes research carried out on mice whose DNA had been altered with a human growth hormone gene is now ripe for reinterpretation after a new study by researchers at KU Leuven confirms that the gene had an unintended effect on the mice's insulin production, a key variable in diabetes research.

The altered strain acted like a member of the new group, suggesting the genes dictate group membership, the researchers report online today in PLOS Biology.

Special strains of the adenovirus, the researchers say, have been altered to deploy anticancer genes within tumors, killing cancer cells while leaving healthy ones unscathed.

For each gene, the researchers compared the number of single letter mutations that alter the encoded protein versus silent mutations that have no effect.

With two altered copies of the gene, flies live only about 20 % longer than the norm, the researchers report in the 15 December issue of Science.

Earlier this month, a team of researchers at the Johns Hopkins Kimmel Cancer Center in Baltimore, Maryland, announced on Science Express that they had found nearly 200 genes altered in breast and colorectal cancers.

Researchers at The Rockefeller University have shown that a new technique using RNA interference is able to find genes that cause epidermal tumor growth in months rather than the decades it may take using traditional methods employing specially bred, genetically altered mice.

The researchers could detect when RNAi occurred, because the cells would alter their normal course of cell division or fail to express the marker gene.

Furthermore, besides offering valuable insight into the function of this novel RNA type, the researchers also believe that the findings will open new avenues for novel treatments in which cell - specific enhancer sequences can be targeted to alter gene expression.

In a race with other scientists, Scottish researchers have bred mice with an altered gene which displays all the key features of cystic fibrosis, such as lung disease and digestive problems.

In combination with a separate technique that measures the degree to which a gene is expressed, the researchers then identified genes that were either mutated or functionally altered through expression levels in these bladder cancer cell lines.

The researchers showed these relationships between ecRNA production and gene activity in neurons included genes whose expression is altered by neuronal activity and genes implicated in developmental and neurodegenerative disorders.

On January 9, a team, led by researchers at Massachusetts General Hospital (MGH) and Children's Hospital Boston, announced that it had found copy number variations — deletions of duplications of segments of genetic code that alter the number of copies of a gene a person carries — in 12 of 1,400 autism sufferers it was studying.

Increasingly, autism researchers are predicting that personalized, more effective treatments will come from understanding these common brain pathways — and how different gene variations alter them.

Other researchers have looked beyond changes in behavior or physical features for «parallel evolution» in the genes, finding, for instance, that different insects alter the same DNA to help them feed on toxic plants.

First, the researchers analyze sequence data from an individual's tumor and identify four to 10 genes altered in the cells.

If, for instance, a researcher finds that dozens of genes in a microarray are differentially expressed on a high - fat purified ingredient diet compared to a low - fat GB diet, it is tempting to conclude that gene expression was altered due to the differences in fat levels between the diets.

By directly altering the gene coding for the prion protein (PrP), Whitehead Institute researchers have created mouse models of two neurodegenerative prion diseases, each of which manifests in different regions of the brain.

In their new study, the researchers traced the weakened enamel in their rats to pollution - altered genes.

The researchers also showed just how flexible their LITE system could be by applying it to altering gene expression via epigenetics with the addition of histone modifiers.

Since the initial Michigan trial, the liposomal transport system — developed by researchers at Vical, a San Diego - based biopharmaceutical company interested in gene therapy — has been altered in ways that are expected to make it safer, more effective and easier to administer.

PULLMAN — Researchers at Washington State University have identified a new class of DNA sequence variation in gene promoter regions that could help control the activity of genes.The novel variations, dubbed «multiple nucleotide length polymorphisms,» or MNLPs, altered transcription of the genes they were associated with as much as 11-fold.

A novel study from researchers at Karolinska Institutet shows that by using so called random sequence labels, working as barcodes for tracing genetically altered cells, during CRISPR / Cas9 gene knock - outs it is possible to generate more comprehensive data from a smaller number of cells.

Researchers have also found the gene that underlie the altered metabolism that protects against arsenic.

Using gene editing technology, the researchers demonstrated that they could rapidly create a quick - flowering tomato plant by altering one of the genes.

The researchers also found that knockout mice, which lack a functional DMRT3 gene, have an altered pattern of locomotion.