The researchers built a protein structure, called «alpha sheet,» that complements the toxic structure of amyloid proteins that they discovered in computer simulations.
1990 - 92 — Robert Rose and other Rochester
researchers build a protein coat that mimics the shape of an HPV envelope without any viral DNA inside.
Not exact matches
At the end of the study, the
researchers compared the muscle
building potential of each group — as measured by the «net
protein balance.»
Researchers at the University of Tampa used Growing Naturals» Organic Rice
Protein made with Axiom Food's Oryzatein ® and followed 24 college - aged, resistance - trained participants, observing how they
built muscle and experienced rates of repair and soreness.
A double blind study published in the June 2013 issue of the Nutrition Journal was done at the University of Tampa where sports nutrition
researchers compared rice and whey
protein with subjects who were
building muscle and looking to reduce soreness quickly so they can return to training.
Paul metropolitan area during the 2009 - 2010 school year to a series of five questions about muscle - enhancing behaviors, two healthy (changing eating patterns and exercising more) and three unhealthy (using
protein powders or shakes, taking steroids, or employing another muscle -
building substance such as creatine, amino acids, HMB, DHEA, or growth hormone),
researchers at the University of Minnesota and Columbia University found that almost all students surveyed (90 % of boys, 80 % of girls) reported doing at least 1 behavior with this as the goal, and up to one - third reported the use of unhealthy methods.
Now,
researchers have demonstrated that two iron - containing small - molecule catalysts can help turn certain types of amino acids — the
building blocks of peptides and
proteins — into an array of potential new forms, even when part of a larger peptide, while preserving a crucial aspect of their chemistry: chirality, or «handedness.»
Synthetic biology enables
researchers to tackle a huge and diverse range of applied problems:
building a cell with the smallest possible genome; synthesizing
proteins with extra amino acids — more than the 20 found in nature; using bacteria to produce medicines previously too complex to synthesize; even decomposing living organisms into standard, off - the - shelf «biobricks» that can be assembled on demand.
To that end,
researchers are pursuing materials that mimic the
building blocks of
proteins — amino acids.
Glycine, the smallest of the 20 amino acids that
build proteins, is floating in the tenuous atmosphere of comet 67P / Churyumov - Gerasimenko,
researchers report online May 27 in...
A team of
researchers at the University of Buffalo discovered a peptide (a
protein building block), GSMtx - 4, in the tarantula's venom that prevents fibrillation by blocking the activity of certain gate - like structures of neurons in the heart.
Medical treatment that targets human
proteins rather than ever - mutating viruses may one day help HIV - positive people whose bodies have
built a resistance to «cocktails» currently used to keep them healthy, according to a Keck School of Medicine of USC
researcher.
But Holtzman and other
researchers previously demonstrated that plaques of amyloid - beta
protein build up faster in the brains of APOE4 carriers (SN: 7/30/11, p. 9).
Gevorg Grigoryan, an assistant professor of computer science at Dartmouth College, and
researchers from other institutions have
built the first artificial transporter
protein that carries individual atoms across membranes, opening the possibility of engineering a new class of smart molecules with applications in fields as wide ranging as nanotechnology and medicine.
The
researchers set out to «
build» an artificial transporter
protein from scratch, to learn how transporters work, and to open the possibility of engineering a new class of smart molecules.
Again, the
researchers do not yet know how problems with
protein -
building machinery lead to depression and suicide.
In May
researchers at McGill University reported that the gene responsible for creating cells»
protein -
building machinery is more frequently methylated in the hippocampus — the brain region responsible for short - term memory and spatial navigation — of depressed suicide victims who suffered child abuse than in the brains of nonsuicide victims who were not abused.
Biological chemist Carlo Unverzagt of the University of Bayreuth in Germany notes that the purity of their chemical
building blocks decreased with each step of synthesis, and that the
researchers failed to obtain a mass spectrum of the final folded
protein.
Researchers are relying on graphics processing units to help
build a highly complex computer simulation depicting how chromatophore
proteins create photosynthesis
When they compared the amino acid sequence of naked mole rat
protein, the
researchers found that three of these
protein building blocks were different from the rat version and one was also different from the same
protein in other mole rats.
Researchers once thought that extra carbon dioxide in the atmosphere might allow crops to bulk up and
build more
protein.
Researchers hypothesized the reason might be that the plants don't get enough nitrogen — a crucial
building block for
proteins — to sustain their spurt.
The
researchers wanted to know which signals in the brain were responsible for
building long - term memory and for forming the special
proteins involved.
That's according to
researchers from The University of Manchester who have discovered that the virus
protein uses its flexible arms to pass on viral
building blocks to the
proteins of cells that it hijacks.
People who consume 18 grams of
protein from whole eggs or from egg whites after engaging in resistance exercise differ dramatically in how their muscles
build protein, a process called
protein synthesis, during the post-workout period,
researchers report in a new study.
To reduce tau, the
researchers used an antisense oligonucleotide, a kind of molecule that interferes with the instructions for
building proteins.
By adding a new base pair, X and Y, to DNA's A-T and G - C pairs,
researchers will enable organisms to
build proteins from as many as 172 different amino acids.
King and his fellow
researcher, Krishna Sigdel, a postdoctoral fellow in the Department of Physics, solved the problem by
building their own force microscope that is able to study membrane
proteins in conditions similar to those found in the body.
Researchers believe the disease progresses because of sticky clumps of beta - amyloid
proteins that form and
build up between neurons, eventually killing them.
The
researchers found specifically that HSF - 1 up - regulates another gene, pat - 10, that produces a
protein that stabilizes actin, the
building blocks of the cytoskeleton.
Published online ahead of print in the leading microbiology journal Molecular Microbiology, the
researchers have identified a
building block common to many types of bacterial «virulence factors» (the bacterial
proteins which act as weapons to cause disease, such as toxins or degrading enzymes).
The
researchers started by determining SOBER1's amino acid sequence — the particular order of
building blocks that gives a
protein its basic identity.
The research could help other scientists to use cryo - EM in structure - based drug design studies — in which
researchers build the best possible drugs starting from a molecule which already binds to the active site of a target
protein.
Researchers working in the new field of synthetic biology can imagine other
building blocks: different
proteins, amino acids (the core components of
proteins), and metabolic systems that would work just as well as, or perhaps even better than, the ones we know.
The
researchers dubbed the new gene nucleostemin, because the
protein built by the gene appears to be almost exclusively active within the cell nucleus.
Eventually the
researchers plan to replace the glowing
protein gene with genes that make biocement, creating a «thinking soil» that will keep
buildings safe and be a self - constructing foundation.
More than half — 60 percent — did not vary at all; the
researchers found the same levels of mRNA — the molecule that links a gene and the
protein it helps
build — in all four for most genes.
Into each well,
researchers insert a copy of a DNA polymerase
protein that reads the letters in a DNA strand and uses that information to
build a complementary strand, in which A's bind to T's, and C's to G's.
Just two amino acids — the
building blocks of
protein — need to change on the virus's surface in order to allow it to spread easily between people, the
researchers found.
The
researchers had previously
built a mathematical model that simulates the activity of a blood - vessel - growth - promoting
protein called VEGF in a mouse tumor.
The
researchers found that the ALS / FTD mutation produces an abnormal version of a
protein called TIA1 that is a
building block of such organelles.
«The multifunctional
protein we've
built can be compared to a Swiss Army knife,» said Raul Gonzalez - Esquer, MSU doctoral
researcher and the paper's lead author.
After that, the
researchers back - translate the amino acid sequence into a genetic sequence, buy the DNA base pairs to
build the gene spelled out by that sequence, and then turn the gene loose in bacteria or yeast that have been programmed to manufacture the
protein.
Researchers have also created a whole kit of
proteins that might be used someday to
build nanowires that carry electrical signals, cages that contain and safely deliver drugs, or latticework that acts a mat on which to grow new cells to heal wounds.
Researchers will be able to study the materials of everyday life, from plastics and
proteins to medicines and molecules, in order to understand how they are
built up and how they work.
The pre-clinical study results show that the synthesized steroid, squalamine, prevents and eliminates alpha - synuclein
build - up inside neurons by unsticking the
protein from the inner wall of nerve cells, where it clings and clusters into toxic clumps,
researchers say.
In their study, published in the October issue of Biomaterials Science, the
researchers built a drug delivery system using apoferritin, the same ball of natural
proteins that carries iron around in blood without letting the iron leak out.
The pre-clinical study results show that squalamine prevents and eliminates α - synuclein
build up inside neurons by unsticking the
protein from the inner wall of nerve cells, where it clings and
builds up into toxic clumps,
researchers say.
The
researchers suspect that the
proteins fold up to form a pocket that serves as the binding site for the drugs and have
built a model of its possible configuration.
On top of that, Jahns has been
building his own siRNAs, creating new structures that allow
researchers to see how they interact with
proteins that help them stay stable.