Sentences with phrase «researchers give a drug»

The researchers gave the drug to 10 rhesus monkeys and compared them with five control monkeys.

To test it, the researchers gave the drug to mice whose hearts were injured to mimic heart failure.

Next, the researchers gave the drug to older mice that already showed signs of aging, such as muscle loss.

Any time researchers give a drug to people for the first time, they start with a very low dose.

The researchers gave a drug called GW1516, which increases the activity of PPAR - delta, to young adult mice for five weeks.

Not exact matches

For future studies, they suggested, researchers should test the performance of doped chess players given a much longer time limit, so the study could isolate the positive effects of brain drugs.

To confirm that breast milk's protective properties were due to EGF, the researchers gave premature baby mice a drug that selectively turned off their cell receptors to EGF — a technique that prevents EGF from entering the gut cells.

This study, performed by Swansea University researchers of 48,000 women who gave birth to healthy (singleton) babies over 10 years, found that women who took these drugs had a 7 % chance of lowered milk production.

When the researchers gave the mice a drug called lamotrigine, often prescribed for bipolar disorder, the animals» brain activity mimicked that of their resilient counterparts: The neurons in the already hyperactive VTA started firing even more intensely, followed by a lull and abatement of depression symptoms.

The researchers then examined the opposite effect: slowing neurogenesis in infant mice by giving them a drug.

To learn how prostate tumours become drug resistant, researchers led by Michael Karin at the University of California, San Diego, implanted prostate tumours into mice and gave them anti-androgens.

Researchers led by Xiao - Jiang Li, MD, PhD and Shihua Li, MD, at Emory University School of Medicine, used genetically engineered mice in which the huntingtin gene can be deleted, triggered only when the mice are given the drug tamoxifen.

In a blinded test, researchers don't know whether they are giving patients the drug being tested or fake medicine.

The main purpose of phase I clinical trials are to evaluate the safety of a new drug, helping researchers determine the maximum dose that can be given safely as well as any harmful side effects.

A clinical trial conducted by researchers at the Virginia G. Piper Cancer Center Clinical Trials, a partnership between Scottsdale Healthcare and the Translational Genomics Research Institute (TGen), showed that a new drug called MM - 398, given in combination with 5 - flourouracil (5FU) and leucovorin, produced a significant overall survival rate in patients with advanced, previously - treated pancreatic cancer.

When the researchers gave digoxin to mice that had E. lenta in their guts, higher levels of the active drug appeared in mice on a high - protein diet (containing arginine) than in mice that went without protein.

The arrival of a powerful drug in the late - 20th century gave researchers new hope.

Now researchers at Abington - Jefferson Health have shown that patients who were given the drugs off - label had no stroke or other cardiovascular side - effects from taking the drugs.

Researchers report that a new wirelessly controlled microchip, implanted under the skin, can safely and reliably give osteoporosis patients the daily dose of a drug that they need for at least 20 days in a row.

After giving healthy volunteers a single low dose of the drug, expression of antithrombin was reduced by 28 — 32 % — an outcome that Sorensen says left the researchers «very surprised».

However, the researchers uncovered several mechanisms leading to tumor resistance, giving them insight into which drugs could combat the resistant cancer.

The genetic code also holds clues to Chlamydia's surface proteins, which Stephens says should give researchers new targets for vaccines, diagnostic tests, and drugs.

Many researchers believe that psychedelic effects are driven in large part by expectations of the experience so neither monitors nor subjects knew when they would be given the psychoactive drug.

A drug that attaches only to that DREADD is then administered to give the researchers control over the circuit.

The researchers say that the glutamate receptor blocker drug seemed to reduce fear relapses in the mice given alcohol.

Ever since it was given a name, many researchers and physicians have viewed the malady, which has no Food and Drug Administration — approved treatment and no diagnostic test, as psychosomatic.

Now, version 3.0 has a unique three - pronged approach to killing bacteria that could give doctors a powerful new weapon against drug - resistant bacteria and help researchers engineer more durable antibiotics.

When the researchers gave OV329 to cocaine - or nicotine - addicted rats, dopamine spikes were neutralized, blocking the addictive reward response and halting the animals» self - administration of the drugs.

To see if the FAK drug works in more complex living systems, the researchers gave mice with DCIS a treatment to block FAK.

For treatment, that knowledge could make a huge impact: not only should researchers be better about testing potential migraine drugs on men and women separately, Maleki says, but they may be able to design new treatments based on these brain differences — giving both sexes a better chance at relief.

In a final experiment, when the researchers gave the bees a drug that disrupted receptors for dopamine, a neurotransmitter linked with motivation and reward, the bias disappeared, echoing the way this brain chemical works in mammals.

By giving an experimental drug along with a narcotic, a team of researchers has eliminated the opiate's potentially lethal side effect while preserving its ability to blunt pain.

Building on each subsequent experiment, researchers using Valdar and Lenarcic's methodology could eventually pinpoint which genetic variations play roles in the side effects of a given drug.

Published in the journal Neuroscience online Nov. 26, and led by researchers at NYU School of Medicine, the new study found that giving the drug to newborn mice 15 minutes after «binge» alcohol consumption eliminated the hyperactivity and sleep deficits seen when rodents exposed to alcohol became adults.

Clinicians and researchers have raised ethical questions about the transplant, as well as concerns about whether Dinoire was stable enough to give informed consent for the procedure — which dips into uncharted issues involving the relationship between the face and personal identity — and for the regimen of immunosuppressive drugs she must now take for the rest of her life.

Next, the researchers gave the non-protected zebrafish an investigational drug, CLRO1, being developed by UCLA scientists that breaks up the protein aggregates, or clumps, in Parkinson's patients.

Using this apparatus, the researchers can manufacture about 1,000 doses of a given drug in 24 hours.

Better drugs could provide relief, but before giving new medicines to people, researchers must first test them in animals — a costly and laborious process.

And researchers found that, indeed, mice given the drug, or with the gene removed, could recover from morning surgery (mice mornings being nighttime, since they are nocturnal) with fewer side effects than usual.

Researchers led by Nigel Bamford of the University of Washington in Seattle, US, gave mice large doses of methamphetamine, equivalent to those taken by addicts during drug binges, to see how this affected communication between cells in the brain's cortex and those in a region of the brain called the striatum.

By engineering red blood cells to have «sticky» proteins on their surface, a team of researchers has given the cells the ability to carry anything from drugs to treat immune disorders or cancer to radioactive molecules used in imaging of blood vessels.

Using two components to form the gel also gives the researchers the opportunity to deliver two different drugs at the same time.

To confirm that their findings are relevant to humans as well, the researchers followed seven individuals given a high dose of saccharin — 5 milligrams per kilogram of body weight, the Food and Drug Administration's maximum acceptable daily intake — on 6 consecutive days.

Lead researchers Eric Reiman and Pierre Tariot of the Banner Alzheimer's Institute in Phoenix plan to give a yet - to - be identified anti-amyloid drug, or placebo, to 650 people who carry two copies of the APOE4 gene — a genetic double whammy that confers a 10-fold increased risk of developing Alzheimer's late in life.

Researchers have found that people with advanced head and neck squamous cell carcinoma and the KRAS - variant inherited genetic mutation have significantly improved survival when given a short course of the drug cetuximab in combination with standard chemotherapy and radiation.

Using a drug made from three mouse antibodies, the researchers said it protected two out of four non-human primates that were given the treatment two days after infection.

By focusing on treatments that act early, before a person is infected and feels sick, the researchers hope to give malaria — especially drug - resistant strains — less time to spread.

John Tanner, a professor in the MU Department of Biochemistry, says mapping this enzyme will give researchers a better understanding of its function, which could help drug manufacturers create more effective drugs.

Then, when the researchers gave the mice a drug, the death pathway would be activated in all senescent cells.

Yet when Evans and his colleagues recently gave a PPAR & # 948 - boosting drug to normal adult mice, the rodents developed no greater stamina than nondoped counterparts — until the researchers had the animals combine the drug with a workout routine.